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01-03-2021 | Hydrocephalus | Original Article

Pediatric choroid plexus papilloma arising from the cerebellopontine angle: systematic review with illustrative case

Authors: Mairre James S. Gaddi, Jeffrey I. Lappay, Kevin Ivan P. Chan, Juan Silvestre G. Pascual, Alaric Emmanuel M. Salonga

Published in: Child's Nervous System | Issue 3/2021

Abstract

Introduction

Choroid plexus tumors are uncommon intraventricular tumors that develop from the choroid plexus of the central nervous system. Choroid plexus papillomas arising from the cerebellopontine angle have been reported to almost exclusively occur in adults and are rarely found in children.

Methods

We report a systematic review conducted in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines of SCOPUS and PubMed databases for case reports and case series of choroid plexus papillomas arising in the cerebellopontine angle in the pediatric population and discuss clinical presentation, imaging features, management options, and outcomes. We also report a case managed at our center.

Results

Ten cases of pediatric choroid plexus papillomas arising in the cerebellopontine angle were identified from the systematic review in addition to the case reported here, resulting in a total of eleven cases. The patients’ median age was 8 years with a slight female sex predilection (1.2:1). Patients most commonly presented with headache, cerebellar signs, and cranial nerve palsies with median duration of symptoms at 4 months. All patients underwent surgical treatment with majority achieving gross total excision. No deaths were reported at median follow-up of 12 months. Complete neurologic recovery was attained in seven cases while partial recovery was seen in two cases.

Conclusion

Choroid plexus papillomas found in the cerebellopontine angle in the pediatric population are extremely rare but they should be considered in the differential diagnosis. Complete surgical resection is the mainstay of treatment with excellent outcomes achievable in majority of patients.

Prasad GL, Mahapatra AK (2015) Case series of choroid plexus papilloma in children at uncommon locations and review of the literature. Surg Neurol Int 6(1). Retrieved May 14, 2020. http://surgicalneurologyint.com/Case-series-of-choroid-plexus-papilloma-in-children-at-uncommon-locations-and-review-of-the-literature

Louis DN, Perry A, Reifenberger G, von Deimling A, Figarella-Branger D, Cavenee WK et al (2016) The 2016 WHO classification of tumors of the central nervous system. Acta Neuropathol 131:803–820CrossRef

Bettegowda C, Adogwa O, Mehta V, Chaichana KL, Weingart J, Carson BS, Jallo GI, Ahn ES (2012) Treatment of choroid plexus tumors: a 20-year single institutional experience. J Neurosurg Pediatr 10(5):398–405. Retrieved May 25, 2020. Available from: https://thejns.org/view/journals/j-neurosurg-pediatr/10/5/article-p398.xml

Furuya K, Sasaki T, Saito N, Atsuchi M, Kirino T (1995) Primary large choroid plexus papillomas in the cerebellopontine angle: radiological manifestations and surgical management. Acta Neurochir 135(3–4):144–149CrossRef

Wolff JEA, Sajedi M, Brant R, Coppes MJ, Egeler RM (2002) Choroid plexus tumours. Br J Cancer 87(10):1086–1091CrossRef

Tacconi L, Delfini R, Cantore G (1996) Choroid plexus papillomas: consideration of a surgical series of 33 cases. Acta Neurochir 138(7):802–810CrossRef

Luo W, Liu H, Li J, Yang J, Xu Y (2016) Choroid plexus papillomas of the cerebellopontine angle. World Neurosurg 95(6):117–125. Retrieved May 14, 2020. Available from: http://link.springer.com/10.1007/BF02341477

Trybula SJ, Karras C, Bowman RM, Alden TD, DiPatri AJ, Tomita T (2020) Infratentorial choroid plexus tumors in children. Childs Nerv Syst 1–6. Retrieved May 25, 2020. https://doi.org/10.1007/s00381-020-04532-7

Hammock MK, Milhorat TH, Breckbill DL (1976) Primary choroid plexus papilloma of the cerebellopontine angle presenting as brain stem tumor in a child. Childs Brain 2(2):132–142PubMed

10.

Piguet V, De Tribolet N (1984) Choroid plexus papilloma of the cerebellopontine angle presenting as a subarachnoid hemorrhage: case report. Neurosurgery. 15(1):114–116CrossRef

11.

Talacchi A, De Micheli E, Lombardo C, Turazzi S, Bricolo A (1999) Choroid plexus papilloma of the cerebellopontine angle: a twelve patient series. Surg Neurol 51(6):621–629. Retrieved May 14, 2020. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0090301999000245

12.

Spallone A, Pastore FS, Hagi MO (1986) Choroid plexus papillomas of the cerebellopontine angle in a child. Ital J Neurol Sci 7(6):613–616. Available from: https://doi.org/10.1016/j.wneu.2016.07.094

13.

Tomita T, Grahovac G (2015) Cerebellopontine angle tumors in infants and children. Childs Nerv Syst 31(10):1739–1750CrossRef

14.

Holman MA, Schmitt WR, Carlson ML, Driscoll CLW, Beatty CW, Link MJ (2013) Pediatric cerebellopontine angle and internal auditory canal tumors. J Neurosurg Pediatr 12(4):317–324CrossRef

15.

Phi JH, Wang KC, Kim IO, Cheon JE, Choi JW, Cho BK, Kim SK (2013) Tumors in the cerebellopontine angle in children: warning of a high probability of malignancy. J Neuro-Oncol 112(3):383–391CrossRef

16.

Zúccaro G, Sosa F (2007) Cerebellopontine angle lesions in children. Childs Nerv Syst 23(2):177–183CrossRef

17.

Ogiwara H, Dipatri AJ, Alden TD, Bowman RM, Tomita T (2012) Choroid plexus tumors in pediatric patients. Br J Neurosurg 26(1):32–37CrossRef

18.

Safaee M, Clark AJ, Bloch O, Oh MC, Singh A, Auguste KI, Gupta N, McDermott MW, Aghi MK, Berger MS, Parsa AT (2013) Surgical outcomes in choroid plexus papillomas: an institutional experience. J Neuro-Oncol 113(1):117–125CrossRef

19.

Kapoor A, Aggarwal A, Ahuja C, Salunke P (2016) Primary choroid plexus papilloma of cerebellopontine angle: an unusual entity in infancy. J Pediatr Neurosci 11(3):287–288CrossRef

20.

Siu A, Lee M, Rice R, Myseros JS (2014) Association of cerebellopontine angle atypical teratoid/rhabdoid tumors with acute facial nerve palsy in infants: report of 3 cases. J Neurosurg Pediatr 13(1):29–32CrossRef

21.

Pencalet P, Sainte-Rose C, Lellouch-Tubiana A, Kalifa C, Brunelle F, Sgouros S, Meyer P, Cinalli G, Zerah M, Pierre-Kahn A, Renier D (1998) Papillomas and carcinomas of the choroid plexus in children. J Neurosurg 88(3):521–528CrossRef

22.

Shin JH, Lee HK, Jeong AK, Park SH, Choi CG, Suh DC (2001) Choroid plexus papilloma in the posterior cranial fossa: MR, CT, and angiographic findings. Clin Imaging 25(3):154–162CrossRef

23.

Shi YZ, Wang ZQ, Xu YM, Lin YF (2014) MR findings of primary choroid plexus papilloma of the cerebellopontine angle: report of three cases and literature reviews. Clin Neuroradiol 24(3):263–267CrossRef

24.

Koeller KK (2002) From the archives of the AFIP cerebral Intraventricular neoplasms: radiologic-pathologic correlation. RadioGraphics. 22:3691473–3691505CrossRef

25.

Lena G, Genitori L, Molina J, Legatte JRS, Choux M (1990) Choroid plexus tumours in children. Review of 24 cases. Acta Neurochir 106(1–2):68–72. Retrieved May 25, 2020. Available from: http://link.springer.com/10.1007/BF01809335

26.

Laurence KM (1979) The biology of choroid plexus papilloma in infancy and childhood. Acta Neurochir 50(1–2):79–90CrossRef

27.

Sarkar C, Sharma MC, Gaikwad S, Sharma C, Singh VP (1999) Choroid plexus papilloma: a clinicopathological study of 23 cases. Surg Neurol 52(1):37–39CrossRef

28.

Emami-Naeini P, Nejat F, Khashab M (2008) Cystic choroid plexus papilloma with multiple mural nodules in an infant. Childs Nerv Syst 24(5):629–631CrossRef

29.

Tomita T, McLone DG, Naidich TP (1986) Mural tumors with cysts in the cerebral hemispheres of children. Neurosurgery 19(6):998–1005. Retrieved May 25, 2020. Available from: https://academic.oup.com/neurosurgery/article/19/6/998/2752804

30.

Murata M, Morokuma S, Tsukimori K, Hojo S, Morioka T, Hashiguchi K, Sasaki T, Wake N (2009) Rapid growing cystic variant of choroid plexus papilloma in a fetal cerebral hemisphere. Ultrasound Obstet Gynecol 33(1):116–118. Retrieved May 25, 2020. Available from: http://doi.wiley.com/10.1002/uog.6262

31.

Miyagi Y, Natori Y, Suzuki SO, Iwaki T, Morioka T, Arimura K et al (2006) Purely cystic form of choroid plexus papilloma with acute hydrocephalus in an infant: Case report. J Neurosurg 105 PEDIAT(SUPPL. 6):480–484

32.

Patanakar T, Prasad S, Mukherji SK, Armao D (2000) Cystic variant of choroid plexus papilloma. Clin Imaging 24(3):130–131CrossRef

33.

Lam S, Reddy G, Lin Y, Jea A (2015) Management of hydrocephalus in children with posterior fossa tumors. Surg Neurol Int 6:S346–S348CrossRef

34.

Fritsch MJ, Doerner L, Kienke S, Mehdorn HM (2005) Hydrocephalus in children with posterior fossa tumors: Role of endoscopic third ventriculostomy. J Neurosurg 103 PEDIAT(SUPPL. 1):40–42

35.

Schijman E, Peter JC, Rekate HL, Sgouros S, Wong TT (2004) Management of hydrocephalus in posterior fossa tumors: how, what, when? Childs Nerv Syst 20(3):192–194CrossRef

36.

Safaee M, Oh MC, Sughrue ME, Delance AR, Bloch O, Sun M et al (2013) The relative patient benefit of gross total resection in adult choroid plexus papillomas. J Clin Neurosci 20(6):808–812. Available from: https://doi.org/10.1016/j.jocn.2012.08.003

37.

Krishnan S, Brown PD, Scheithauer BW, Ebersold MJ, Hammack JE, Buckner JC (2004) Choroid plexus papillomas: a single institutional experience. J Neuro-Oncol 68(1):49–55CrossRef

38.

Packer RJ, Perilongo G, Johnson D, Sutton LN, Vezina G, Zimmerman RA, Ryan J, Reaman G, Schut L (1992) Choroid plexus carcinoma of childhood. Cancer. 69(2):580–585CrossRef

Title: Pediatric choroid plexus papilloma arising from the cerebellopontine angle: systematic review with illustrative case
Authors: Mairre James S. Gaddi
Jeffrey I. Lappay
Kevin Ivan P. Chan
Juan Silvestre G. Pascual
Alaric Emmanuel M. Salonga
Publication date: 01-03-2021
Publisher: Springer Berlin Heidelberg
Keywords: Hydrocephalus
Hydrocephalus
Hydrocephalus
Headache
Published in: Child's Nervous System / Issue 3/2021
Print ISSN: 0256-7040
Electronic ISSN: 1433-0350
DOI: https://doi.org/10.1007/s00381-020-04896-w

At a glance: The STEP trials

Springer Medicine

Pediatric choroid plexus papilloma arising from the cerebellopontine angle: systematic review with illustrative case

Abstract

Introduction

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusion

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