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Child's Nervous System
Published in: Child's Nervous System 9/2016

01-09-2016 | Original Paper

Epileptic seizure in primary intracranial sarcoma: a case report and literature review

Authors: Yen-Ping Chen, Hsiu-Fen Lee, Tai-Tong Wong

Published in: Child's Nervous System | Issue 9/2016

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Abstract

Purpose

The aim of this study is to describe epileptic seizures in patients with primary intracranial sarcomas.

Methods

We report a 17-year-old girl diagnosed with primary high-grade intracranial sarcoma with initial clinical manifestation of nonconvulsive status epilepticus. Literature reports between 2000 and 2014, relevant to primary intracranial sarcomas in children, were reviewed. The clinical presentations and neurological outcomes were analyzed.

Results

Eleven of 29cases (38 %), 8 males and 3 females, who exhibited epileptic seizures as one of the initial symptoms and diagnosed with primary intracranial sarcomas were collected. The median age of disease onset was 5 years. The two most common seizure types were generalized seizures (45 %) and status epilepticus (36 %). Nine of 11 patients (82 %) had tumor growth involving the frontal lobe. Nine cases had the median duration of follow-up 1.7 years, of which 6 cases showed tumor recurrence and 3 cases died during the period of follow-up.

Conclusions

Epileptic seizures as one of the clinical manifestations are uncommon. The two most common seizure types were generalized seizures and status epilepticus. The most frequent location of primary intracranial sarcoma-related seizures was the frontal lobe. The clinical outcome varied.
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Metadata
Title
Epileptic seizure in primary intracranial sarcoma: a case report and literature review
Authors
Yen-Ping Chen
Hsiu-Fen Lee
Tai-Tong Wong
Publication date
01-09-2016
Publisher
Springer Berlin Heidelberg
Published in
Child's Nervous System / Issue 9/2016
Print ISSN: 0256-7040
Electronic ISSN: 1433-0350
DOI
https://doi.org/10.1007/s00381-016-3174-3

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