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Published in: Journal of Neuro-Oncology 1/2008

01-01-2008 | Clinical-Patient Studies

Successful treatment of a child with a primary intracranial rhabdomyosarcoma with chemotherapy and radiation therapy

Authors: Gregory Michael Taylor Guilcher, Glenda Hendson, Karen Goddard, Paul Steinbok, Mason Bond

Published in: Journal of Neuro-Oncology | Issue 1/2008

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Abstract

Primary rhabdomyosarcoma of the central nervous system (CNS) is rare in both adults and children (Taratuto et al. (1985) Acta Neuropathol (Berl) 66(2):98–104). The outcome in the majority of cases is poor, and many cases are associated with early mortality (Celli et al. (1998) J Neurooncol 36(3):259–267). There are very few cases reported in the literature of survival beyond 2 years after diagnosis. We report a case of primary intracranial embryonal rhabdomyosarcoma in a 5-year-old girl who was treated successfully with local radiation therapy (RT) and a combination of two different chemotherapeutic regimens. The patient is clinically well 26 months after diagnosis, with no definitive evidence of residual disease.
Literature
1.
go back to reference Pizzo PA, Popplack DG (2006) Principles and practice of pediatric oncology, 5th edn. Lippincott Williams and Wilkins, Philadelphia, PA Pizzo PA, Popplack DG (2006) Principles and practice of pediatric oncology, 5th edn. Lippincott Williams and Wilkins, Philadelphia, PA
2.
go back to reference Meza JL, Anderson J, Pappo AS, Meyer WH, Children’s Oncology Group (2006) Analysis of prognostic factors in patients with nonmetastatic rhabdomyosarcoma treated on intergroup rhabdomyosarcoma studies III and IV: the children’s oncology group. J Clin Oncol 24(24):3844–3851PubMedCrossRef Meza JL, Anderson J, Pappo AS, Meyer WH, Children’s Oncology Group (2006) Analysis of prognostic factors in patients with nonmetastatic rhabdomyosarcoma treated on intergroup rhabdomyosarcoma studies III and IV: the children’s oncology group. J Clin Oncol 24(24):3844–3851PubMedCrossRef
3.
go back to reference Taratuto AL, Molina HA, Diez B, Zuccaro G, Monges J (1985) Primary rhabdomyosarcoma of brain and cerebellum. Report of four cases in infants: an immunohistochemical study. Acta Neuropathol (Berl) 66(2):98–104CrossRef Taratuto AL, Molina HA, Diez B, Zuccaro G, Monges J (1985) Primary rhabdomyosarcoma of brain and cerebellum. Report of four cases in infants: an immunohistochemical study. Acta Neuropathol (Berl) 66(2):98–104CrossRef
4.
go back to reference Celli P, Cervoni L, Maraglino C (1998) Primary rhabdomyosarcoma of the brain: observations on a case with clinical and radiological evidence of cure. J Neurooncol 36(3):259–267PubMedCrossRef Celli P, Cervoni L, Maraglino C (1998) Primary rhabdomyosarcoma of the brain: observations on a case with clinical and radiological evidence of cure. J Neurooncol 36(3):259–267PubMedCrossRef
5.
go back to reference Dropcho EJ, Allen JC (1987) Primary intracranial rhabdomyosarcoma: case report and review of the literature. J Neurooncol 5(2):139–150PubMedCrossRef Dropcho EJ, Allen JC (1987) Primary intracranial rhabdomyosarcoma: case report and review of the literature. J Neurooncol 5(2):139–150PubMedCrossRef
6.
go back to reference Hayashi K, Ohtsuki Y, Ikehara I, Akagi T, Murakami M, Date I et al (1986) Primary rhabdomyosarcoma combined with chronic paragonimiasis in the cerebrum: a necropsy case and review of the literature. Acta Neuropathol (Berl) 72(2):170–177CrossRef Hayashi K, Ohtsuki Y, Ikehara I, Akagi T, Murakami M, Date I et al (1986) Primary rhabdomyosarcoma combined with chronic paragonimiasis in the cerebrum: a necropsy case and review of the literature. Acta Neuropathol (Berl) 72(2):170–177CrossRef
7.
go back to reference Tomei G, Grimoldi N, Cappricci E, Sganzerla EP, Gaini SM, Villani R et al (1989) Primary intracranial rhabdomyosarcoma: report of two cases. Childs Nerv Syst 5(4):246–249PubMedCrossRef Tomei G, Grimoldi N, Cappricci E, Sganzerla EP, Gaini SM, Villani R et al (1989) Primary intracranial rhabdomyosarcoma: report of two cases. Childs Nerv Syst 5(4):246–249PubMedCrossRef
8.
go back to reference Yagishita S, Itoh Y, Chiba Y, Fujino H (1979) Primary rhabdomyosarcoma of the cerebrum. an ultrastructural study. Acta Neuropathol (Berl) 45(2):111–115CrossRef Yagishita S, Itoh Y, Chiba Y, Fujino H (1979) Primary rhabdomyosarcoma of the cerebrum. an ultrastructural study. Acta Neuropathol (Berl) 45(2):111–115CrossRef
9.
go back to reference Matsukado Y, Yokota A, Marubayashi T (1975) Rhabdomyosarcoma of the brain. J Neurosurg 43(2):215–221PubMedCrossRef Matsukado Y, Yokota A, Marubayashi T (1975) Rhabdomyosarcoma of the brain. J Neurosurg 43(2):215–221PubMedCrossRef
10.
go back to reference Shin KH, Whitehead VM (1980) Rhabdomyosarcoma of the brain. Can J Surg 23(6):576–578PubMed Shin KH, Whitehead VM (1980) Rhabdomyosarcoma of the brain. Can J Surg 23(6):576–578PubMed
11.
go back to reference Olson JJ, Menezes AH, Godersky JC, Lobosky JM, Hart M (1985) Primary intracranial rhabdomyosarcoma. Neurosurgery 17(1):25–34PubMedCrossRef Olson JJ, Menezes AH, Godersky JC, Lobosky JM, Hart M (1985) Primary intracranial rhabdomyosarcoma. Neurosurgery 17(1):25–34PubMedCrossRef
12.
go back to reference Michalski JM, Meza J, Breneman JC, Wolden SL, Laurie F, Jodoin M et al (2004) Influence of radiation therapy parameters on outcome in children treated with radiation therapy for localized parameningeal rhabdomyosarcoma in intergroup rhabdomyosarcoma study group trials II through IV. Int J Radiat Oncol Biol Phys 59(4):1027–1038PubMedCrossRef Michalski JM, Meza J, Breneman JC, Wolden SL, Laurie F, Jodoin M et al (2004) Influence of radiation therapy parameters on outcome in children treated with radiation therapy for localized parameningeal rhabdomyosarcoma in intergroup rhabdomyosarcoma study group trials II through IV. Int J Radiat Oncol Biol Phys 59(4):1027–1038PubMedCrossRef
13.
go back to reference Regine WF, Fontanesi J, Kumar P, Ayers D, Bowman LC, Pappo AS et al (1995) Local tumor control in rhabdomyosarcoma following low-dose irradiation: Comparison of group II and select group III patients. Int J Radiat Oncol Biol Phys 31(3):485–491PubMedCrossRef Regine WF, Fontanesi J, Kumar P, Ayers D, Bowman LC, Pappo AS et al (1995) Local tumor control in rhabdomyosarcoma following low-dose irradiation: Comparison of group II and select group III patients. Int J Radiat Oncol Biol Phys 31(3):485–491PubMedCrossRef
14.
go back to reference Van Winkle P, Angiolillo A, Krailo M, Cheung YK, Anderson B, Davenport V et al (2005) Ifosfamide, carboplatin, and etoposide (ICE) reinduction chemotherapy in a large cohort of children and adolescents with recurrent/refractory sarcoma: the children’s cancer group (CCG) experience. Pediatr Blood Cancer 44(4):338–347PubMedCrossRef Van Winkle P, Angiolillo A, Krailo M, Cheung YK, Anderson B, Davenport V et al (2005) Ifosfamide, carboplatin, and etoposide (ICE) reinduction chemotherapy in a large cohort of children and adolescents with recurrent/refractory sarcoma: the children’s cancer group (CCG) experience. Pediatr Blood Cancer 44(4):338–347PubMedCrossRef
15.
go back to reference Lopez-Aguilar E, Sepulveda-Vildosola AC, Rivera-Marquez H, Cerecedo-Diaz F, Hernandez-Contreras I, Ramon-Garcia G et al (2000) Preirradiation ifosfamide, carboplatin, and etoposide for the treatment of anaplastic astrocytomas and glioblastoma multiforme: a phase II study. Arch Med Res 31(2):186–190PubMedCrossRef Lopez-Aguilar E, Sepulveda-Vildosola AC, Rivera-Marquez H, Cerecedo-Diaz F, Hernandez-Contreras I, Ramon-Garcia G et al (2000) Preirradiation ifosfamide, carboplatin, and etoposide for the treatment of anaplastic astrocytomas and glioblastoma multiforme: a phase II study. Arch Med Res 31(2):186–190PubMedCrossRef
Metadata
Title
Successful treatment of a child with a primary intracranial rhabdomyosarcoma with chemotherapy and radiation therapy
Authors
Gregory Michael Taylor Guilcher
Glenda Hendson
Karen Goddard
Paul Steinbok
Mason Bond
Publication date
01-01-2008
Publisher
Springer US
Published in
Journal of Neuro-Oncology / Issue 1/2008
Print ISSN: 0167-594X
Electronic ISSN: 1573-7373
DOI
https://doi.org/10.1007/s11060-007-9435-y

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