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Published in: Heart and Vessels 10/2017

Open Access 01-10-2017 | Original Article

Effects of pitavastatin on walking capacity and CD34+/133+ cell number in patients with peripheral artery disease

Authors: Kenshiro Arao, Takanori Yasu, Yasuhiro Endo, Toshikazu Funazaki, Yoshimi Ota, Kazunori Shimada, Eiichi Tokutake, Naoki Naito, Bonpei Takase, Minoru Wake, Nahoko Ikeda, Yasuto Horie, Hiroyuki Sugimura, Shin-ichi Momomura, Masanobu Kawakami, Investigators of the Anti-Arteriosclerosis and Lipid Lowering with Pitavastatin Evaluation Study in Nippon (ALPEN)

Published in: Heart and Vessels | Issue 10/2017

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Abstract

This multi-center prospective non-randomized comparative study investigated the effects of pitavastatin in patients with peripheral artery disease (PAD) in terms of exercise tolerance capacities and peripheral CD34+/133+ cell numbers. At baseline, a peripheral blood test was administered to 75 patients with PAD, along with a treadmill exercise test using the Skinner–Gardner protocol to measure asymptomatic walking distance (AWD) and maximum walking distance (MWD). Each patient was assigned to a 6-month pitavastatin treatment group (n = 53) or a control group (n = 22), according to the patient’s preference. The tests were repeated in both groups at 3 and 6 months. Baseline AWD and MWD correlated positively with the ankle-brachial pressure index (r = 0.342, p = 0.0032 and r = 0.324, p = 0.0054, respectively). Both AWD and MWD values improved at 3 and 6 months compared with baseline, and the degrees of their improvement were higher in the pitavastatin treatment group. CD34+/133+ cell numbers did not change over time or between groups. Eighty-seven percent of patients in the treatment group attained low-density lipoprotein cholesterol levels below 100 mg/dL after 3 months. The study shows that pitavastatin may be effective in increasing exercise tolerance capacity in patients with PAD.
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Metadata
Title
Effects of pitavastatin on walking capacity and CD34+/133+ cell number in patients with peripheral artery disease
Authors
Kenshiro Arao
Takanori Yasu
Yasuhiro Endo
Toshikazu Funazaki
Yoshimi Ota
Kazunori Shimada
Eiichi Tokutake
Naoki Naito
Bonpei Takase
Minoru Wake
Nahoko Ikeda
Yasuto Horie
Hiroyuki Sugimura
Shin-ichi Momomura
Masanobu Kawakami
Investigators of the Anti-Arteriosclerosis and Lipid Lowering with Pitavastatin Evaluation Study in Nippon (ALPEN)
Publication date
01-10-2017
Publisher
Springer Japan
Published in
Heart and Vessels / Issue 10/2017
Print ISSN: 0910-8327
Electronic ISSN: 1615-2573
DOI
https://doi.org/10.1007/s00380-017-0988-1

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