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Published in: Heart and Vessels 10/2017

01-10-2017 | Original Article

Anatomical visualization of neural course and distribution of anterior ascending aortic plexus

Authors: Tomokazu Kawashima, Fumi Sato

Published in: Heart and Vessels | Issue 10/2017

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Abstract

The aim of this study was to document the detailed anatomy of neural course and distribution on the anterior ascending aorta, to identify the high and low density areas of the anterior ascending aortic plexus for further understandings in cardiovascular surgery. The embalmed hearts of 42 elderly individuals were submacroscopically and microscopically examined, after excluding any that were macroscopically abnormal. With its origins in the anterior ascending aortic plexus, the right coronary plexus substantially innervated the right coronary artery, the right atrium and ventricle, and the sinus node. The intensive neural area extending from 10 mm lateral to the interatrial groove below the pericardial reflection as far as the right coronary artery opening contained almost all the right coronary plexus in 61.3% of patients, and more than 40.9% of the total nerve volume of the anterior ascending aortic plexus. Our findings suggest that the most superior and lateral area on the ascending aorta show the lowest neural density of right coronary component in the anterior ascending aortic plexus and the high density areas are invisible in right lateral field of view as seen in the right trans-axillary MICS approach.
Literature
1.
go back to reference Pauza DH, Skripka V, Pauziene N, Stropus R (2000) Morphology, distribution, and variability of the epicardiac neural ganglionated subplexuses in the human heart. Anat Rec 259:353–382CrossRefPubMed Pauza DH, Skripka V, Pauziene N, Stropus R (2000) Morphology, distribution, and variability of the epicardiac neural ganglionated subplexuses in the human heart. Anat Rec 259:353–382CrossRefPubMed
2.
go back to reference Kawashima T (2005) The autonomic nervous system of the human heart with special reference to its origin, course, and peripheral distribution. Anat Embryol 209:425–438CrossRefPubMed Kawashima T (2005) The autonomic nervous system of the human heart with special reference to its origin, course, and peripheral distribution. Anat Embryol 209:425–438CrossRefPubMed
3.
go back to reference Vaitkevicius R, Saburkina I, Rysevaite K, Vaitkeviciene I, Pauziene N, Zaliunas R, Schauerte P, Jalife J, Pauza DH (2009) Nerve supply of the human pulmonary veins: an anatomical study. Heart Rhythm 6:221–228CrossRefPubMed Vaitkevicius R, Saburkina I, Rysevaite K, Vaitkeviciene I, Pauziene N, Zaliunas R, Schauerte P, Jalife J, Pauza DH (2009) Nerve supply of the human pulmonary veins: an anatomical study. Heart Rhythm 6:221–228CrossRefPubMed
4.
go back to reference Kawashima T (2011) Anatomy of the cardiac nervous system with clinical and comparative morphological implications. Anat Sci Int 86:30–49CrossRefPubMed Kawashima T (2011) Anatomy of the cardiac nervous system with clinical and comparative morphological implications. Anat Sci Int 86:30–49CrossRefPubMed
5.
go back to reference Petraitiene V, Pauza DH, Benetis R (2014) Distribution of adrenergic and cholinergic nerve fibers within intrinsic nerves at the level of the human heart hilum. Eur J Cardiothorac Surg 45:1097–1105CrossRefPubMed Petraitiene V, Pauza DH, Benetis R (2014) Distribution of adrenergic and cholinergic nerve fibers within intrinsic nerves at the level of the human heart hilum. Eur J Cardiothorac Surg 45:1097–1105CrossRefPubMed
6.
go back to reference Pauza DH, Rysevaite-Kyguoliene K, Vismantaite J, Brack KE, Inokaitis H, Pauza AG, Rimasauskaite-Petraitienė V, Pauzaite JI, Pauziene N (2014) A combined acetylcholinesterase and immunohistochemical method for precise anatomical analysis of intrinsic cardiac neural structures. Ann Anat 196:430–440CrossRefPubMed Pauza DH, Rysevaite-Kyguoliene K, Vismantaite J, Brack KE, Inokaitis H, Pauza AG, Rimasauskaite-Petraitienė V, Pauzaite JI, Pauziene N (2014) A combined acetylcholinesterase and immunohistochemical method for precise anatomical analysis of intrinsic cardiac neural structures. Ann Anat 196:430–440CrossRefPubMed
7.
go back to reference Stamou SC, Kapetanakis EI, Lowery R, Jablonski KA, Frankel TL, Corso PJ (2003) Allogeneic blood transfusion requirements after minimally invasive versus conventional aortic valve replacement: a risk-adjusted analysis. Ann Thorac Surg 76:1101–1106CrossRefPubMed Stamou SC, Kapetanakis EI, Lowery R, Jablonski KA, Frankel TL, Corso PJ (2003) Allogeneic blood transfusion requirements after minimally invasive versus conventional aortic valve replacement: a risk-adjusted analysis. Ann Thorac Surg 76:1101–1106CrossRefPubMed
8.
go back to reference Vanoverbeke H, Van Belleghem Y, Francois K, Caes F, Bove T, Van Nooten G (2004) Operative outcome of minimal access aortic valve replacement versus standard procedure. Acta Chir Belg 104:440–444PubMed Vanoverbeke H, Van Belleghem Y, Francois K, Caes F, Bove T, Van Nooten G (2004) Operative outcome of minimal access aortic valve replacement versus standard procedure. Acta Chir Belg 104:440–444PubMed
9.
go back to reference Sharony R, Grossi EA, Saunders PC, Schwartz CF, Ribakove GH, Baumann FG, Galloway AC, Clvin SB (2004) Propensity score analysis of a six-year experience with minimally invasive isolate aortic valve replacement. J Heart Valve Dis 13:887–893PubMed Sharony R, Grossi EA, Saunders PC, Schwartz CF, Ribakove GH, Baumann FG, Galloway AC, Clvin SB (2004) Propensity score analysis of a six-year experience with minimally invasive isolate aortic valve replacement. J Heart Valve Dis 13:887–893PubMed
10.
go back to reference Bakir I, Casselman FP, Wellens F, Jeanmart H, GeestR De, Degrieck I, Van Praet F, Vermeulen Y, Vanermen H (2006) Minimally invasive versus standard approach aortic valve replacement: a study in 506 patients. Ann Thorac Surg 81:1599–1604CrossRefPubMed Bakir I, Casselman FP, Wellens F, Jeanmart H, GeestR De, Degrieck I, Van Praet F, Vermeulen Y, Vanermen H (2006) Minimally invasive versus standard approach aortic valve replacement: a study in 506 patients. Ann Thorac Surg 81:1599–1604CrossRefPubMed
11.
go back to reference Rosengart TK, Feldman T, Borger MA, Vassiliades TA Jr, Gillinov AM, Hoercher KJ, Vahanian A, Bonow RO, O’Neill W (2008) Percutaneous and minimally invasive valve procedures: a scientific statement from the American Heart Association Council on Cardiovascular Surgery and Anesthesia, Council on Clinical Cardiology, Functional Genomics and Translational Biology Interdisciplinary Working Group, and Quality of Care and Outcomes Research Interdisciplinary Working Group. Circulation 117:1750–1767CrossRefPubMed Rosengart TK, Feldman T, Borger MA, Vassiliades TA Jr, Gillinov AM, Hoercher KJ, Vahanian A, Bonow RO, O’Neill W (2008) Percutaneous and minimally invasive valve procedures: a scientific statement from the American Heart Association Council on Cardiovascular Surgery and Anesthesia, Council on Clinical Cardiology, Functional Genomics and Translational Biology Interdisciplinary Working Group, and Quality of Care and Outcomes Research Interdisciplinary Working Group. Circulation 117:1750–1767CrossRefPubMed
12.
go back to reference Yan L, Zhou ZC, Li HP, Lin M, Wang HT, Zhao ZW, Gao QY, Ge JJ (2013) Right vertical infra-axillary mini-incision for repair of simple congenital heart defects: a matched-pair analysis. Eur J Cardiothorac Surg 43:136–141CrossRefPubMed Yan L, Zhou ZC, Li HP, Lin M, Wang HT, Zhao ZW, Gao QY, Ge JJ (2013) Right vertical infra-axillary mini-incision for repair of simple congenital heart defects: a matched-pair analysis. Eur J Cardiothorac Surg 43:136–141CrossRefPubMed
14.
go back to reference Ohnuma T, Kimura N, Sasabuchi Y, Asaka K, Shiotsuka J, Komuro T, Mouri H, Lefor AT, Adachi H, Sanui M (2015) Lower heart rate in the early postoperative period does not correlate with long-term outcomes after repair of type A acute aortic dissection. Heart Vessels 30:355–361CrossRefPubMed Ohnuma T, Kimura N, Sasabuchi Y, Asaka K, Shiotsuka J, Komuro T, Mouri H, Lefor AT, Adachi H, Sanui M (2015) Lower heart rate in the early postoperative period does not correlate with long-term outcomes after repair of type A acute aortic dissection. Heart Vessels 30:355–361CrossRefPubMed
15.
go back to reference Colli A, Carrozzini M, Galuppo M, Comisso M, Toto F, Gregori D, Gerosa G (2016) Analysis of early and long-term outcomes of acute type A aortic dissection according to the new international aortic arch surgery study group recommendations. Heart Vessels 31:1616–1624CrossRefPubMed Colli A, Carrozzini M, Galuppo M, Comisso M, Toto F, Gregori D, Gerosa G (2016) Analysis of early and long-term outcomes of acute type A aortic dissection according to the new international aortic arch surgery study group recommendations. Heart Vessels 31:1616–1624CrossRefPubMed
16.
go back to reference Vola M, Guichard JB, Campisi S, Fuzellier JF, Gerbay A, Doguet F, Isaaz K, Azarnoush K, Anselmi A, Ruggieri VG (2016) Sutureless aortic bioprosthesis valve implantation and bicuspid valve anatomy: an unsolved dilemma? Heart Vessels 31:1783–1789CrossRefPubMed Vola M, Guichard JB, Campisi S, Fuzellier JF, Gerbay A, Doguet F, Isaaz K, Azarnoush K, Anselmi A, Ruggieri VG (2016) Sutureless aortic bioprosthesis valve implantation and bicuspid valve anatomy: an unsolved dilemma? Heart Vessels 31:1783–1789CrossRefPubMed
17.
go back to reference Cappabianca G, Ferrarese S, Musazzi A, Terrieri F, Corazzari C, Matteucci M, Beghi C (2016) Predictive factors of long-term survival in the octogenarian undergoing surgical aortic valve replacement: 12-year single-centre follow-up. Heart Vessels 31:1798–1805CrossRefPubMed Cappabianca G, Ferrarese S, Musazzi A, Terrieri F, Corazzari C, Matteucci M, Beghi C (2016) Predictive factors of long-term survival in the octogenarian undergoing surgical aortic valve replacement: 12-year single-centre follow-up. Heart Vessels 31:1798–1805CrossRefPubMed
18.
go back to reference Sündermann SH, Czesla M, Kempfert J, Walther T, Nataf P, Raanani E, Jacobs S, Alfieri O, Maisano F, Falk V (2017) Results of mitral valve repair with an adjustable annuloplasty ring 2 years after implantation. Heart Vessels. doi:10.1007/s00380-016-0934-7 PubMed Sündermann SH, Czesla M, Kempfert J, Walther T, Nataf P, Raanani E, Jacobs S, Alfieri O, Maisano F, Falk V (2017) Results of mitral valve repair with an adjustable annuloplasty ring 2 years after implantation. Heart Vessels. doi:10.​1007/​s00380-016-0934-7 PubMed
19.
go back to reference Bisleri G, Di Bacco L, Giroletti L, Muneretto C (2017) Total arterial grafting is associated with improved clinical outcomes compared to conventional myocardial revascularization at 10 years follow-up. Heart Vessels 32:109–116CrossRefPubMed Bisleri G, Di Bacco L, Giroletti L, Muneretto C (2017) Total arterial grafting is associated with improved clinical outcomes compared to conventional myocardial revascularization at 10 years follow-up. Heart Vessels 32:109–116CrossRefPubMed
20.
go back to reference Kato T, Tsunekawa T, Motoji Y, Hirakawa A, Okawa Y, Tomita S (2017) The side-to-side fashion for individual distal coronary anastomosis using venous conduit. Heart Vessels 32:385–389CrossRefPubMed Kato T, Tsunekawa T, Motoji Y, Hirakawa A, Okawa Y, Tomita S (2017) The side-to-side fashion for individual distal coronary anastomosis using venous conduit. Heart Vessels 32:385–389CrossRefPubMed
21.
go back to reference Awad M, Czer LSC, Hou M, Golshani SS, Goltche M, De Robertis M, Kittleson M, Patel J, Azarbal B, Kransdorf E, Esmailian F (2016) Early denervation and later reinnervation of the heart following cardiac transplantation: a review. J Am Heart Assoc 5:e004070CrossRefPubMedPubMedCentral Awad M, Czer LSC, Hou M, Golshani SS, Goltche M, De Robertis M, Kittleson M, Patel J, Azarbal B, Kransdorf E, Esmailian F (2016) Early denervation and later reinnervation of the heart following cardiac transplantation: a review. J Am Heart Assoc 5:e004070CrossRefPubMedPubMedCentral
22.
go back to reference Buendía-Fuentes F, Martínez-Dolz L, Almenar Bonet L, Sánchez-Lázaro I, Navarro Manchon J, Sánchez-Gómez JM, Raso Raso R, Agüero-Ramón-Llin J, Sancho-Tello de Carranza MJ, Salvador Sanz A (2010) Normalization of the heart rate response to exercise 6 months after cardiac transplantation. Transplant Proc 42:3186–3188CrossRefPubMed Buendía-Fuentes F, Martínez-Dolz L, Almenar Bonet L, Sánchez-Lázaro I, Navarro Manchon J, Sánchez-Gómez JM, Raso Raso R, Agüero-Ramón-Llin J, Sancho-Tello de Carranza MJ, Salvador Sanz A (2010) Normalization of the heart rate response to exercise 6 months after cardiac transplantation. Transplant Proc 42:3186–3188CrossRefPubMed
23.
go back to reference Castel MÁ, Roig E, Rios J, Tomas C, Mirabet S, Cardona M, Brossa V, López L, Vargas L, Sinonis A, Vallejos I, Pérez-Villa F (2013) Long-term prognostic value of elevated heart rate one year after heart transplantation. Int J Cardiol 168:2003–2007CrossRefPubMed Castel MÁ, Roig E, Rios J, Tomas C, Mirabet S, Cardona M, Brossa V, López L, Vargas L, Sinonis A, Vallejos I, Pérez-Villa F (2013) Long-term prognostic value of elevated heart rate one year after heart transplantation. Int J Cardiol 168:2003–2007CrossRefPubMed
24.
25.
go back to reference Ab Shah, Patel JK, Rafiei M, Morrissey RP, Kittleson MM, Kobashigawa JA (2013) The impact of mean first-year heart rate on outcomes after heart transplantation: does it make a difference? Clin Transplant 27:659–665CrossRef Ab Shah, Patel JK, Rafiei M, Morrissey RP, Kittleson MM, Kobashigawa JA (2013) The impact of mean first-year heart rate on outcomes after heart transplantation: does it make a difference? Clin Transplant 27:659–665CrossRef
26.
go back to reference Bengel FM, Ueberfuhr P, Schiepel N, Nekolla SG, Reichart B, Schwaiger M (2001) Effect of sympathetic reinnervation on cardiac performance after heart transplantation. N Engl J Med 345:731–738CrossRefPubMed Bengel FM, Ueberfuhr P, Schiepel N, Nekolla SG, Reichart B, Schwaiger M (2001) Effect of sympathetic reinnervation on cardiac performance after heart transplantation. N Engl J Med 345:731–738CrossRefPubMed
27.
go back to reference Spinarová L, Hude P, Krejčí J, Poloczková H, Godava J, Vítovec J (2012) Farmacotherapy of hypertension after heart transplantation [in Czech]. Vnitr Lek 58:608–611PubMed Spinarová L, Hude P, Krejčí J, Poloczková H, Godava J, Vítovec J (2012) Farmacotherapy of hypertension after heart transplantation [in Czech]. Vnitr Lek 58:608–611PubMed
28.
go back to reference Kawashima T, Sasaki H (2005) Topological changes of the human autonomic cardiac nervous system in individuals with a retroesophageal right subclavian artery: two case reports and a brief review. Anat Embryol 210:327–334CrossRefPubMed Kawashima T, Sasaki H (2005) Topological changes of the human autonomic cardiac nervous system in individuals with a retroesophageal right subclavian artery: two case reports and a brief review. Anat Embryol 210:327–334CrossRefPubMed
29.
go back to reference Kawashima T, Sasaki H (2007) Morphological comparison of the cardiac autonomic nervous system between normal and abnormal great arterial branching pattern with a brief review of the literature. Auton Neurosci 132:37–43CrossRefPubMed Kawashima T, Sasaki H (2007) Morphological comparison of the cardiac autonomic nervous system between normal and abnormal great arterial branching pattern with a brief review of the literature. Auton Neurosci 132:37–43CrossRefPubMed
30.
go back to reference Crick SJ, Sheppard MN, Anderson RH, Polak JM, Wharton J (1996) A quantitative study of nerve distribution in the conduction system of the guinea pig heart. J Anat 188:403–416PubMedPubMedCentral Crick SJ, Sheppard MN, Anderson RH, Polak JM, Wharton J (1996) A quantitative study of nerve distribution in the conduction system of the guinea pig heart. J Anat 188:403–416PubMedPubMedCentral
31.
go back to reference Saburkina I, Pauza DH (2006) Location and variability of epicardiac ganglia in human fetuses. Anat Embryo 211:585–594CrossRef Saburkina I, Pauza DH (2006) Location and variability of epicardiac ganglia in human fetuses. Anat Embryo 211:585–594CrossRef
32.
go back to reference Rysevaite K, Saburkina I, Pauziene N, Noujaim SF, Jalife J, Pauza DH (2011) Morphologic pattern of the intrinsic ganglionated nerve plexus in mouse heart. Heart Rhythm 8:448–454CrossRefPubMed Rysevaite K, Saburkina I, Pauziene N, Noujaim SF, Jalife J, Pauza DH (2011) Morphologic pattern of the intrinsic ganglionated nerve plexus in mouse heart. Heart Rhythm 8:448–454CrossRefPubMed
33.
go back to reference Pauza DH, Saburkina I, Rysevaite K, Inokaitis H, Jokubauskas M, Jalife J, Pauziene N (2013) Neuroanatomy of the murine cardiac conduction system: a combined stereomicroscopic and fluorescence immunohistochemical study. Auton Neurosci 176:32–47CrossRefPubMed Pauza DH, Saburkina I, Rysevaite K, Inokaitis H, Jokubauskas M, Jalife J, Pauziene N (2013) Neuroanatomy of the murine cardiac conduction system: a combined stereomicroscopic and fluorescence immunohistochemical study. Auton Neurosci 176:32–47CrossRefPubMed
34.
go back to reference Compostella L, Russo N, D’Onofrio A, Setzu T, Compostella C, Bottio T, Gerosa G, Bellotto F (2015) Abnormal heart rate variability and atrial fibrillation after aortic surgery. Braz J Cardiovasc Surg 30:55–62 Compostella L, Russo N, D’Onofrio A, Setzu T, Compostella C, Bottio T, Gerosa G, Bellotto F (2015) Abnormal heart rate variability and atrial fibrillation after aortic surgery. Braz J Cardiovasc Surg 30:55–62
Metadata
Title
Anatomical visualization of neural course and distribution of anterior ascending aortic plexus
Authors
Tomokazu Kawashima
Fumi Sato
Publication date
01-10-2017
Publisher
Springer Japan
Published in
Heart and Vessels / Issue 10/2017
Print ISSN: 0910-8327
Electronic ISSN: 1615-2573
DOI
https://doi.org/10.1007/s00380-017-0993-4

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