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01-11-2014 | Original Article

Prognostic impact of lipid contents on the target lesion in patients with drug eluting stent implantation

Authors: Soichiro Kumagai, Hiroaki Takashima, Katsuhisa Waseda, Hirohiko Ando, Akihiro Suzuki, Tadayuki Uetani, Ken Harada, Tomohiro Yoshida, Ayako Kunimura, Yusaku Shimbo, Katsuhide Kitagawa, Kazuhiro Harada, Hideki Ishii, Daiji Yoshikawa, Tatsuaki Matsubara, Toyoaki Murohara, Tetsuya Amano

Published in: Heart and Vessels | Issue 6/2014

Abstract

We sought to determine the morphologic predictors of major adverse cardiac events (MACEs) after successful percutaneous coronary intervention (PCI) with drug-eluting stents (DES), using integrated backscatter intravascular ultrasound (IB-IVUS). Conventional IVUS and IB-IVUS were performed in 260 consecutive patients who underwent PCI with DES. Three-dimensional analyses were performed to determine plaque volume and the volume of each plaque component (lipid, fibrous, and calcification). Patients were divided into two groups according to the median lipid volume (LV) in the target lesion. MACEs were defined as death, nonfatal myocardial infarction, and any repeat revascularization. The median follow-up interval was 1285 days. MACEs were observed in 64 patients (24.6 %). Patients having a larger LV compared with their counterparts had worse long-term clinical outcomes regarding mortality (3.8 vs. 0 %, P = 0.02) and MACEs (31.5 vs. 17.7 %, P = 0.008) by log-rank test. After adjustment for confounders, large LV (odds ratio 1.95, 95 % confidence interval 1.14–3.33, P = 0.02) was significantly and independently associated with MACEs. The assessment of coronary plaque characteristics in the target lesion may be useful to predict long-term outcome following successful coronary intervention.

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Title: Prognostic impact of lipid contents on the target lesion in patients with drug eluting stent implantation
Authors: Soichiro Kumagai
Hiroaki Takashima
Katsuhisa Waseda
Hirohiko Ando
Akihiro Suzuki
Tadayuki Uetani
Ken Harada
Tomohiro Yoshida
Ayako Kunimura
Yusaku Shimbo
Katsuhide Kitagawa
Kazuhiro Harada
Hideki Ishii
Daiji Yoshikawa
Tatsuaki Matsubara
Toyoaki Murohara
Tetsuya Amano
Publication date: 01-11-2014
Publisher: Springer Japan
Published in: Heart and Vessels / Issue 6/2014
Print ISSN: 0910-8327
Electronic ISSN: 1615-2573
DOI: https://doi.org/10.1007/s00380-013-0430-2

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