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Published in: World Journal of Urology 11/2020

01-11-2020 | Kidney Transplantation | Topic Paper

Five compelling UTI questions after kidney transplant

Authors: Selda Aydın, Abhijit Patil, Mahesh Desai, Nasser Simforoosh

Published in: World Journal of Urology | Issue 11/2020

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Abstract

Purpose

Urinary tract infection (UTI) is the most common bacterial infection among infectious complications in kidney transplant recipients (KTR). After transplantation, infections can result from surgical complications, donor-derived infections, pre-existing recipient infections, and nosocomial infections. Post-transplant infection is still a major cause of morbidity, mortality, graft dysfunction and rejection. In this paper, we aimed to review a few compelling questions in kidney transplantation (KTX).

Methods

To identify relevant clinical questions regarding KTX and UTI a meeting was conducted among physicians involved in the KT program in our hospital. After discussion, several clinically relevant questions related to UTI after KTX. The 5 first rated in importance were judged generalizable to other clinical settings and selected for the purposes of this review.

Results

Nearly half of the patients present in the first three months of transplant with UTI. The most common uropathogens in post-transplant UTIs are Escherichia coli, Klebsiella pneumoniae, and Enterococcus faecalis. Risk factors for UTI include female sex, advanced age, recurrent UTI before transplant, prolonged urethral catheterization, delayed graft function, and cadaveric kidney transplant.

Conclusion

The incidence of post-transplant UTI is similar in both developed and developing countries. E.coli is the most common pathogen in most of studies. Cadaveric donor and post-dialysis transplantation are defined as independent risk factors for post-transplant UTI. Further studies are still required to identify risk factors after kidney transplantation and UTI’s importance for graft function and patient outcome.
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Metadata
Title
Five compelling UTI questions after kidney transplant
Authors
Selda Aydın
Abhijit Patil
Mahesh Desai
Nasser Simforoosh
Publication date
01-11-2020
Publisher
Springer Berlin Heidelberg
Published in
World Journal of Urology / Issue 11/2020
Print ISSN: 0724-4983
Electronic ISSN: 1433-8726
DOI
https://doi.org/10.1007/s00345-020-03173-4

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