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Published in: World Journal of Urology 5/2020

01-05-2020 | Transurethral Prostate Resection | Original Article

Bipolar endoscopic enucleation versus bipolar transurethral resection of the prostate: an ESUT systematic review and cumulative analysis

Authors: Davide Arcaniolo, Celeste Manfredi, Alessandro Veccia, Thomas R. W. Herrmann, Estevão Lima, Vincenzo Mirone, Ferdinando Fusco, Cristian Fiori, Alessandro Antonelli, Jens Rassweiler, Evangelos Liatsikos, Francesco Porpiglia, Marco De Sio, Riccardo Autorino, EAU Section of Uro-Technology (ESUT) Research Group

Published in: World Journal of Urology | Issue 5/2020

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Abstract

Purpose

To perform a cumulative analysis of the current evidence on the surgical and functional outcomes of bipolar endoscopic enucleation of the prostate (b-EEP) versus bipolar transurethral resection of the prostate (b-TURP).

Methods

A systematic review of the literature was performed on PubMed, Ovid®, and Scopus® according to Preferred Reporting Items for Systematic Review and Meta-analysis Statement (PRISMA Statement). The meta-analysis was conducted using the Review Manager 5.3 software. Parameters of interest were surgical and functional outcomes. Weighted mean difference, and odds ratio with 95% confidence interval were calculated for continuous and binary variables, respectively. Pooled estimates were calculated using the random-effect model.

Results

Fourteen comparative studies were included. No statistically significant difference in terms of overall baseline characteristics was found. b-EEP had higher amount of resected tissue (p < 0.0001), shorter catheter time (p = 0.006), lower Hb drop (p = 0.03), and shorter length of stay (p < 0.0001). Equally, overall post-operative complications were lower (p = 0.01) as well as short (p = 0.04), and long-term complication rate (p = 0.04). There was higher re-intervention rate in the b-TURP group (p = 0.02) whereas b-EEP group had smaller residual prostate volume (p = 0.03), and lower post-operative PSA values (p < 0.00001). At long term, b-EEP presented lower IPSS (p = 0.04), higher Qmax (p = 0.002), and lower PVR (p < 0.00001).

Conclusions

b-EEP is an effective and safe surgical treatment for BPO. This procedure might offer several advantages over standard b-TURP, including the resection of a larger amount of tissue within the same operative time, shorter hospitalization, lower risk of complications, and lower re-intervention rate.
This was submitted to PROSPERO registry: CRD42019126748.
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Literature
3.
go back to reference Reich O, Gratzke C, Bachmann A, Seitz M, Schlenker B, Hermanek P, Lack N, Stief CG, Urology Section of the Bavarian Working Group for Quality Assurance (2008) Morbidity, mortality and early outcome of transurethral resection of the prostate : a prospective multicenter evaluation of 10,654 patients. J Urol 180:246–249. https://doi.org/10.1016/j.juro.2008.03.058 CrossRefPubMed Reich O, Gratzke C, Bachmann A, Seitz M, Schlenker B, Hermanek P, Lack N, Stief CG, Urology Section of the Bavarian Working Group for Quality Assurance (2008) Morbidity, mortality and early outcome of transurethral resection of the prostate : a prospective multicenter evaluation of 10,654 patients. J Urol 180:246–249. https://​doi.​org/​10.​1016/​j.​juro.​2008.​03.​058 CrossRefPubMed
4.
go back to reference Bhojani N, Gandaglia G, Sood A, Rai A, Pucheril D, Chang SL, Karakiewicz PI, Menon M, Olugbade K Jr, Ruhotina N, Sammon JD, Sukumar S, Sun M, Ghani KR, Schmid M, Varda B, Kibel AS, Zorn KC, Trinh QD (2014) Morbidity and mortality after benign prostatic hyperplasia surgery: data from the American College of Surgeons national surgical quality improvement program. J Endourol 28:831–840. https://doi.org/10.1089/end.2013.0805 CrossRefPubMed Bhojani N, Gandaglia G, Sood A, Rai A, Pucheril D, Chang SL, Karakiewicz PI, Menon M, Olugbade K Jr, Ruhotina N, Sammon JD, Sukumar S, Sun M, Ghani KR, Schmid M, Varda B, Kibel AS, Zorn KC, Trinh QD (2014) Morbidity and mortality after benign prostatic hyperplasia surgery: data from the American College of Surgeons national surgical quality improvement program. J Endourol 28:831–840. https://​doi.​org/​10.​1089/​end.​2013.​0805 CrossRefPubMed
7.
go back to reference Skolarikos A, Rassweiler J, de la Rosette JJ, Alivizatos G, Scoffone C, Scarpa RM, Schulze M, Mamoulakis C (2016) Safety and efficacy of bipolar versus monopolar transurethral resection of the prostate in patients with large prostates or severe lower urinary tract symptoms: post hoc analysis of a European multicenter randomized controlled trial. J Urol 195:677–684. https://doi.org/10.1016/j.juro.2015.08.083 CrossRefPubMed Skolarikos A, Rassweiler J, de la Rosette JJ, Alivizatos G, Scoffone C, Scarpa RM, Schulze M, Mamoulakis C (2016) Safety and efficacy of bipolar versus monopolar transurethral resection of the prostate in patients with large prostates or severe lower urinary tract symptoms: post hoc analysis of a European multicenter randomized controlled trial. J Urol 195:677–684. https://​doi.​org/​10.​1016/​j.​juro.​2015.​08.​083 CrossRefPubMed
8.
go back to reference Lin Y, Wu X, Xu A, Ren R, Zhou X, Wen Y, Zou Y, Gong M, Liu C, Su Z, Herrmann TR (2016) Transurethral enucleation of the prostate versus transvesical open prostatectomy for large benign prostatic hyperplasia: a systematic review and meta-analysis of randomized controlled trials. World J Urol 34:1207–1219. https://doi.org/10.1007/s00345-015-1735-9 CrossRefPubMed Lin Y, Wu X, Xu A, Ren R, Zhou X, Wen Y, Zou Y, Gong M, Liu C, Su Z, Herrmann TR (2016) Transurethral enucleation of the prostate versus transvesical open prostatectomy for large benign prostatic hyperplasia: a systematic review and meta-analysis of randomized controlled trials. World J Urol 34:1207–1219. https://​doi.​org/​10.​1007/​s00345-015-1735-9 CrossRefPubMed
9.
go back to reference Netsch C, Becker B, Tiburtius C, Moritz C, Becci AV, Herrmann TRW, Gross AJ (2017) A prospective, randomized trial comparing thulium vapoenucleation with holmium laser enucleation of the prostate for the treatment of symptomatic benign prostatic obstruction: perioperative safety and efficacy. World J Urol 35:1913–1921. https://doi.org/10.1007/s00345-017-2071-z CrossRefPubMed Netsch C, Becker B, Tiburtius C, Moritz C, Becci AV, Herrmann TRW, Gross AJ (2017) A prospective, randomized trial comparing thulium vapoenucleation with holmium laser enucleation of the prostate for the treatment of symptomatic benign prostatic obstruction: perioperative safety and efficacy. World J Urol 35:1913–1921. https://​doi.​org/​10.​1007/​s00345-017-2071-z CrossRefPubMed
12.
go back to reference Hiraoka Y, Akimoto M (1989) Transurethral enucleation of benign prostatic hyperplasia. J Urol 142:1247–1250CrossRefPubMed Hiraoka Y, Akimoto M (1989) Transurethral enucleation of benign prostatic hyperplasia. J Urol 142:1247–1250CrossRefPubMed
17.
go back to reference Richardson WS, Wilson MC, Nishikawa J, Hayward RS (1995) The well-built clinical question: a key to evidence-based decisions. ACP J Club 123:A12–A13PubMed Richardson WS, Wilson MC, Nishikawa J, Hayward RS (1995) The well-built clinical question: a key to evidence-based decisions. ACP J Club 123:A12–A13PubMed
18.
go back to reference Howick J, Chalmers I, Glasziou P, Heneghan C, Liberati A, Moschetti I, Phillips B, Thornton H (2011) Explanation of the 2011 Oxford Centre for Evidence-Based Medicine (OCEBM) Levels of Evidence (background document). Oxford Centre for Evidence-Based Medicine. http://www.cebm.net/index.aspx?o=5653 Howick J, Chalmers I, Glasziou P, Heneghan C, Liberati A, Moschetti I, Phillips B, Thornton H (2011) Explanation of the 2011 Oxford Centre for Evidence-Based Medicine (OCEBM) Levels of Evidence (background document). Oxford Centre for Evidence-Based Medicine. http://​www.​cebm.​net/​index.​aspx?​o=​5653
19.
go back to reference Wells GA, Shea B, O’Connell D, Robertson J, Peterson J, Welch V, Losos M, Tugwell P (2013) The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomized studies in meta-analyses. Ottawa Hosp Res Inst 1 Wells GA, Shea B, O’Connell D, Robertson J, Peterson J, Welch V, Losos M, Tugwell P (2013) The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomized studies in meta-analyses. Ottawa Hosp Res Inst 1
20.
go back to reference Jadad AR, Moore RA, Carroll D et al (1996) Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials 17:1–12CrossRefPubMed Jadad AR, Moore RA, Carroll D et al (1996) Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials 17:1–12CrossRefPubMed
23.
go back to reference Zhang KY, Xing JC, Chen BS, Liu CX, Lau HW, Sim HG, Foo KT (2011) Bipolar plasmakinetic transurethral resection of the prostate vs. transurethral enucleation and resection of the prostate: pre- and postoperative comparisons of parameters used in assessing benign prostatic enlargement. Singap Med J 52:747–687514 Zhang KY, Xing JC, Chen BS, Liu CX, Lau HW, Sim HG, Foo KT (2011) Bipolar plasmakinetic transurethral resection of the prostate vs. transurethral enucleation and resection of the prostate: pre- and postoperative comparisons of parameters used in assessing benign prostatic enlargement. Singap Med J 52:747–687514
28.
go back to reference Kan CF, Tsu HL, Chiu Y, To HC, Sze B, Chan SW (2014) A prospective study comparing bipolar endoscopic enucleation of prostate with bipolar transurethral resection in saline for management of symptomatic benign prostate enlargement larger than 70 g in a matched cohort. Int Urol Nephrol 46:511–517. https://doi.org/10.1007/s11255-013-0546-4 CrossRefPubMed Kan CF, Tsu HL, Chiu Y, To HC, Sze B, Chan SW (2014) A prospective study comparing bipolar endoscopic enucleation of prostate with bipolar transurethral resection in saline for management of symptomatic benign prostate enlargement larger than 70 g in a matched cohort. Int Urol Nephrol 46:511–517. https://​doi.​org/​10.​1007/​s11255-013-0546-4 CrossRefPubMed
31.
go back to reference Zhang K, Sun D, Zhang H, Cao Q, Fu Q (2015) Plasmakinetic vapor enucleation of the prostate with button electrode versus plasmakinetic resection of the prostate for benign prostatic enlargement > 90 mL: perioperative and 3-month follow-up results of a prospective, randomized clinical trial. Urol Int 95:260–264. https://doi.org/10.1159/000381753 CrossRefPubMed Zhang K, Sun D, Zhang H, Cao Q, Fu Q (2015) Plasmakinetic vapor enucleation of the prostate with button electrode versus plasmakinetic resection of the prostate for benign prostatic enlargement > 90 mL: perioperative and 3-month follow-up results of a prospective, randomized clinical trial. Urol Int 95:260–264. https://​doi.​org/​10.​1159/​000381753 CrossRefPubMed
34.
go back to reference Cho C, Mak CW, Chan WK, Chu WH, Law IC (2017) Bipolar transurethral enucleation and resection of the prostate versus bipolar transurethral resection of the prostate for prostates larger than 80 g: comparison of early postoperative outcome. Surg Pract 21:149–154. https://doi.org/10.1111/1744-1633.12280 CrossRef Cho C, Mak CW, Chan WK, Chu WH, Law IC (2017) Bipolar transurethral enucleation and resection of the prostate versus bipolar transurethral resection of the prostate for prostates larger than 80 g: comparison of early postoperative outcome. Surg Pract 21:149–154. https://​doi.​org/​10.​1111/​1744-1633.​12280 CrossRef
36.
go back to reference Rai P, Srivastva A, Singh S, Dhayal IR (2019) Comparison of safety and efficacy of bipolar plasmakinetic transurethral enucleation and bipolar plasmakinetic transurethral resection of prostate gland greater than 60 g in patients receiving anticoagulants and/or platelet aggregation inhibitors: a tertiary care center experience. Minerva Urol Nefrol. https://doi.org/10.23736/S0393-2249.19.03282-X CrossRefPubMed Rai P, Srivastva A, Singh S, Dhayal IR (2019) Comparison of safety and efficacy of bipolar plasmakinetic transurethral enucleation and bipolar plasmakinetic transurethral resection of prostate gland greater than 60 g in patients receiving anticoagulants and/or platelet aggregation inhibitors: a tertiary care center experience. Minerva Urol Nefrol. https://​doi.​org/​10.​23736/​S0393-2249.​19.​03282-X CrossRefPubMed
38.
go back to reference Naspro R, Gomez Sancha F, Manica M, Meneghini A, Ahyai S, Aho T, Fiori C, Vavassori I, Da Pozzo LF, Pansadoro V, Montorsi F, Herrmann TR (2017) From “gold standard” resection to reproducible “future standard” endoscopic enucleation of the prostate: what we know about anatomical enucleation. Minerva Urol Nefrol 69:446–458. https://doi.org/10.23736/S0393-2249.17.02834-X CrossRefPubMed Naspro R, Gomez Sancha F, Manica M, Meneghini A, Ahyai S, Aho T, Fiori C, Vavassori I, Da Pozzo LF, Pansadoro V, Montorsi F, Herrmann TR (2017) From “gold standard” resection to reproducible “future standard” endoscopic enucleation of the prostate: what we know about anatomical enucleation. Minerva Urol Nefrol 69:446–458. https://​doi.​org/​10.​23736/​S0393-2249.​17.​02834-X CrossRefPubMed
40.
go back to reference Boeri L, Capogrosso P, Ventimiglia E, Fontana M, Sampogna G, Zanetti SP, Pozzi E, Zuabi R, Schifano N, Chierigo F, Longo F, Gadda F, Dell’Orto PG, Scattoni V, Montorsi F, Montanari E, Salonia A (2019) Clinical comparison of holmium laser enucleation of the prostate and bipolar transurethral enucleation of the prostate in patients under either anticoagulation or antiplatelet therapy. Eur Urol Focus. https://doi.org/10.1016/j.euf.2019.03.002 CrossRefPubMed Boeri L, Capogrosso P, Ventimiglia E, Fontana M, Sampogna G, Zanetti SP, Pozzi E, Zuabi R, Schifano N, Chierigo F, Longo F, Gadda F, Dell’Orto PG, Scattoni V, Montorsi F, Montanari E, Salonia A (2019) Clinical comparison of holmium laser enucleation of the prostate and bipolar transurethral enucleation of the prostate in patients under either anticoagulation or antiplatelet therapy. Eur Urol Focus. https://​doi.​org/​10.​1016/​j.​euf.​2019.​03.​002 CrossRefPubMed
43.
go back to reference Sato K, Obinata D, Funakoshi D, Saito F, Takada S, Ito A, Murata Y, Ashikari D, Ikado Y, Igarashi T, Matsui T, Mochida J, Yamanaka Y, Yamaguchi K, Takahashi S (2016) Efficacy of transurethral prostate enucleation by bipolar system for patients with benign prostatic hyperplasia. Minerva Urol Nefrol 68:337–341PubMed Sato K, Obinata D, Funakoshi D, Saito F, Takada S, Ito A, Murata Y, Ashikari D, Ikado Y, Igarashi T, Matsui T, Mochida J, Yamanaka Y, Yamaguchi K, Takahashi S (2016) Efficacy of transurethral prostate enucleation by bipolar system for patients with benign prostatic hyperplasia. Minerva Urol Nefrol 68:337–341PubMed
44.
go back to reference Xiong W, Sun M, Ran Q, Chen F, Du Y, Dou K (2013) Learning curve for bipolar transurethral enucleation and resection of the prostate in saline for symptomatic benign prostatic hyperplasia: experience in the first 100 consecutive patients. Urol Int 90:68–74. https://doi.org/10.1159/000343235 CrossRefPubMed Xiong W, Sun M, Ran Q, Chen F, Du Y, Dou K (2013) Learning curve for bipolar transurethral enucleation and resection of the prostate in saline for symptomatic benign prostatic hyperplasia: experience in the first 100 consecutive patients. Urol Int 90:68–74. https://​doi.​org/​10.​1159/​000343235 CrossRefPubMed
47.
go back to reference Grechenkov A, Sukhanov R, Bezrukov E, Butnaru D, Barbagli G, Vasyutin I, Tivtikyan A, Rapoport L, Alyaev Y, Glybochko P (2018) Risk factors for urethral stricture and/or bladder neck contracture after monopolar transurethral resection of the prostate for benign prostatic hyperplasia. Urologia 85:150–157. https://doi.org/10.1177/0391560318758195 CrossRefPubMed Grechenkov A, Sukhanov R, Bezrukov E, Butnaru D, Barbagli G, Vasyutin I, Tivtikyan A, Rapoport L, Alyaev Y, Glybochko P (2018) Risk factors for urethral stricture and/or bladder neck contracture after monopolar transurethral resection of the prostate for benign prostatic hyperplasia. Urologia 85:150–157. https://​doi.​org/​10.​1177/​0391560318758195​ CrossRefPubMed
50.
go back to reference Giulianelli R, Gentile BC, Mirabile G, Tema G, Albanesi L, Tariciotti P, Rizzo G, Falavolti C, Aloisi P, Vincenti G, Lombardo R (2019) Bipolar plasma enucleation of the prostate vs. open prostatectomy in large benign prostatic hyperplasia: a single centre 3-year comparison. Prostate Cancer Prostatic Dis 22:110–116. https://doi.org/10.1038/s41391-018-0080-7 CrossRefPubMed Giulianelli R, Gentile BC, Mirabile G, Tema G, Albanesi L, Tariciotti P, Rizzo G, Falavolti C, Aloisi P, Vincenti G, Lombardo R (2019) Bipolar plasma enucleation of the prostate vs. open prostatectomy in large benign prostatic hyperplasia: a single centre 3-year comparison. Prostate Cancer Prostatic Dis 22:110–116. https://​doi.​org/​10.​1038/​s41391-018-0080-7 CrossRefPubMed
51.
go back to reference Lebdai S, Chevrot A, Doizi S, Pradere B, Delongchamps NB, Benchikh A, Cornu JN, Della Negra E, Fourmarier M, Misraï V, Theveniaud PE, Descazeaud A, Robert G, CTMH-AFU group (2019) Do patients have to choose between ejaculation and miction? A systematic review about ejaculation preservation technics for benign prostatic obstruction surgical treatment. World J Urol 37:299–308. https://doi.org/10.1007/s00345-018-2368-6 CrossRefPubMed Lebdai S, Chevrot A, Doizi S, Pradere B, Delongchamps NB, Benchikh A, Cornu JN, Della Negra E, Fourmarier M, Misraï V, Theveniaud PE, Descazeaud A, Robert G, CTMH-AFU group (2019) Do patients have to choose between ejaculation and miction? A systematic review about ejaculation preservation technics for benign prostatic obstruction surgical treatment. World J Urol 37:299–308. https://​doi.​org/​10.​1007/​s00345-018-2368-6 CrossRefPubMed
Metadata
Title
Bipolar endoscopic enucleation versus bipolar transurethral resection of the prostate: an ESUT systematic review and cumulative analysis
Authors
Davide Arcaniolo
Celeste Manfredi
Alessandro Veccia
Thomas R. W. Herrmann
Estevão Lima
Vincenzo Mirone
Ferdinando Fusco
Cristian Fiori
Alessandro Antonelli
Jens Rassweiler
Evangelos Liatsikos
Francesco Porpiglia
Marco De Sio
Riccardo Autorino
EAU Section of Uro-Technology (ESUT) Research Group
Publication date
01-05-2020
Publisher
Springer Berlin Heidelberg
Published in
World Journal of Urology / Issue 5/2020
Print ISSN: 0724-4983
Electronic ISSN: 1433-8726
DOI
https://doi.org/10.1007/s00345-019-02890-9

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