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01-08-2020 | COVID-19 | Chest

CT image visual quantitative evaluation and clinical classification of coronavirus disease (COVID-19)

Authors: Kunwei Li, Yijie Fang, Wenjuan Li, Cunxue Pan, Peixin Qin, Yinghua Zhong, Xueguo Liu, Mingqian Huang, Yuting Liao, Shaolin Li

Published in: European Radiology | Issue 8/2020

Abstract

Objectives

To explore the relationship between the imaging manifestations and clinical classification of COVID-19.

Methods

We conducted a retrospective single-center study on patients with COVID-19 from Jan. 18, 2020 to Feb. 7, 2020 in Zhuhai, China. Patients were divided into 3 types based on Chinese guideline: mild (patients with minimal symptoms and negative CT findings), common, and severe-critical (patients with positive CT findings and different extent of clinical manifestations). CT visual quantitative evaluation was based on summing up the acute lung inflammatory lesions involving each lobe, which was scored as 0 (0%), 1 (1–25%), 2 (26–50%), 3 (51–75%), or 4 (76–100%), respectively. The total severity score (TSS) was reached by summing the five lobe scores. The consistency of two observers was evaluated. The TSS was compared with the clinical classification. ROC was used to test the diagnosis ability of TSS for severe-critical type.

Results

This study included 78 patients, 38 males and 40 females. There were 24 mild (30.8%), 46 common (59.0%), and 8 severe-critical (10.2%) cases, respectively. The median TSS of severe-critical-type group was significantly higher than common type (p < 0.001). The ICC value of the two observers was 0.976 (95% CI 0.962–0.985). ROC analysis showed the area under the curve (AUC) of TSS for diagnosing severe-critical type was 0.918. The TSS cutoff of 7.5 had 82.6% sensitivity and 100% specificity.

Conclusions

The proportion of clinical mild-type patients with COVID-19 was relatively high; CT was not suitable for independent screening tool. The CT visual quantitative analysis has high consistency and can reflect the clinical classification of COVID-19.

Key Points

• CT visual quantitative evaluation has high consistency (ICC value of 0.976) among the observers. The median TSS of severe-critical type group was significantly higher than common type (p < 0.001).

• ROC analysis showed the area under the curve (AUC) of TSS for diagnosing severe-critical type was 0.918 (95% CI 0.843–0.994). The TSS cutoff of 7.5 had 82.6% sensitivity and 100% specificity.

• The proportion of confirmed COVID-19 patients with normal chest CT was relatively high (30.8%); CT was not a suitable screening modality

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Title: CT image visual quantitative evaluation and clinical classification of coronavirus disease (COVID-19)
Authors: Kunwei Li
Yijie Fang
Wenjuan Li
Cunxue Pan
Peixin Qin
Yinghua Zhong
Xueguo Liu
Mingqian Huang
Yuting Liao
Shaolin Li
Publication date: 01-08-2020
Publisher: Springer Berlin Heidelberg
Keyword: COVID-19
Published in: European Radiology / Issue 8/2020
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-020-06817-6

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

CT image visual quantitative evaluation and clinical classification of coronavirus disease (COVID-19)

Abstract

Objectives

Methods

Results

Conclusions

Key Points

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusions

Key Points

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