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European Radiology
Published in: European Radiology 1/2020

01-01-2020 | Imaging Informatics and Artificial Intelligence

Quality of science and reporting of radiomics in oncologic studies: room for improvement according to radiomics quality score and TRIPOD statement

Authors: Ji Eun Park, Donghyun Kim, Ho Sung Kim, Seo Young Park, Jung Youn Kim, Se Jin Cho, Jae Ho Shin, Jeong Hoon Kim

Published in: European Radiology | Issue 1/2020

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Abstract

Objectives

To evaluate radiomics studies according to radiomics quality score (RQS) and Transparent Reporting of a multivariable prediction model for Individual Prognosis Or Diagnosis (TRIPOD) to provide objective measurement of radiomics research.

Materials and methods

PubMed and Embase were searched for studies published in high clinical imaging journals until December 2018 using the terms “radiomics” and “radiogenomics.” Studies were scored against the items in the RQS and TRIPOD guidelines. Subgroup analyses were performed for journal type (clinical vs. imaging), intended use (diagnostic vs. prognostic), and imaging modality (CT vs. MRI), and articles were compared using Fisher’s exact test and Mann-Whitney analysis.

Results

Seventy-seven articles were included. The mean RQS score was 26.1% of the maximum (9.4 out of 36). The RQS was low in demonstration of clinical utility (19.5%), test-retest analysis (6.5%), prospective study (3.9%), and open science (3.9%). None of the studies conducted a phantom or cost-effectiveness analysis. The adherence rate for TRIPOD was 57.8% (mean) and was particularly low in reporting title (2.6%), stating study objective in abstract and introduction (7.8% and 16.9%), blind assessment of outcome (14.3%), sample size (6.5%), and missing data (11.7%) categories. Studies in clinical journals scored higher and more frequently adopted external validation than imaging journals.

Conclusions

The overall scientific quality and reporting of radiomics studies is insufficient. Scientific improvements need to be made to feature reproducibility, analysis of clinical utility, and open science categories. Reporting of study objectives, blind assessment, sample size, and missing data is deemed to be necessary.

Key Points

• The overall scientific quality and reporting of radiomics studies is insufficient.
• The RQS was low in demonstration of clinical utility, test-retest analysis, prospective study, and open science.
• Room for improvement was shown in TRIPOD in stating study objective in abstract and introduction, blind assessment of outcome, sample size, and missing data categories.
Appendix
Available only for authorised users
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Metadata
Title
Quality of science and reporting of radiomics in oncologic studies: room for improvement according to radiomics quality score and TRIPOD statement
Authors
Ji Eun Park
Donghyun Kim
Ho Sung Kim
Seo Young Park
Jung Youn Kim
Se Jin Cho
Jae Ho Shin
Jeong Hoon Kim
Publication date
01-01-2020
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 1/2020
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-019-06360-z

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