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European Radiology
Published in: European Radiology 11/2019

01-11-2019 | Magnetic Resonance Imaging | Urogenital

Value of blood oxygenation level-dependent MRI for predicting clinical outcomes in uterine cervical cancer treated with concurrent chemoradiotherapy

Authors: Jiyeong Lee, Chan Kyo Kim, Kyo-won Gu, Won Park

Published in: European Radiology | Issue 11/2019

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Abstract

Objectives

To investigate the value of blood oxygenation level-dependent (BOLD) MRI as a predictor of clinical outcomes in cervical cancer patients treated with concurrent chemoradiotherapy (CCRT).

Method

Enrolled 92 patients with stage IB2–IVB cervical cancer who received CCRT underwent 3-T BOLD MRI before treatment. The R2* value (rate of spin dephasing, s−1) was measured in the tumor. Cox regression analysis was used to evaluate the associations of imaging and clinical parameters with progression-free survival (PFS) and cancer-specific survival (CSS). Inter-reader reliability for the R2* measurements was evaluated using an intraclass correlation coefficient (ICC).

Results

Tumor R2* values were significantly different between patients with and without disease progression (p < 0.001). Multivariate analysis demonstrated that tumor R2* value was significantly independent factor for PFS (hazard ratio [HR] = 5.746, p < 0.001) and CSS (HR = 12.878, p = 0.001). Additionally, squamous cell carcinoma antigen (HR = 1.027, p = 0.001) was significantly independent factor for PFS. Inter-reader reliability for the R2* measurements was good (ICC = 0.702).

Conclusion

Pretreatment 3-T BOLD MRI may be useful for predicting clinical outcomes in uterine cervical cancer patients treated with CCRT, with good inter-reader reliability.

Key Points

• Tumor R2* values are different between patients with and without disease progression.
• The R2* value is an independent factor for treatment outcomes in cervical cancer.
• Inter-reader reliability for R2* measurements using BOLD MRI is good.
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Metadata
Title
Value of blood oxygenation level-dependent MRI for predicting clinical outcomes in uterine cervical cancer treated with concurrent chemoradiotherapy
Authors
Jiyeong Lee
Chan Kyo Kim
Kyo-won Gu
Won Park
Publication date
01-11-2019
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 11/2019
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-019-06198-5

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