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Open Access 01-11-2019 | Breast Cancer | Breast

Correlation between quantitative assessment of contrast enhancement in contrast-enhanced spectral mammography (CESM) and histopathology—preliminary results

Authors: Wojciech Rudnicki, Sylwia Heinze, Joanna Niemiec, Zbigniew Kojs, Beata Sas-Korczynska, Ed Hendrick, Elzbieta Luczynska

Published in: European Radiology | Issue 11/2019

Abstract

Objectives

Contrast-enhanced spectral mammography (CESM) is a novel method for breast cancer detection. The aim of this study is to check if there is a possibility of quantitative assessment of contrast enhancement in CESM and if there is any correlation between quantitative assessment of contrast enhancement in CESM and histopathology.

Methods

A total of 167 female patients underwent CESM. All subjects previously had suspicious lesions found on mammography, breast ultrasound, or both. After imaging, the following parameters were evaluated: number of enhancing lesions in each breast and size and degree of enhancement of each lesion. Based on the collected data, the percentage signal difference between enhancing lesion and background (%RS) and signal-difference-to-noise ratio (SDNR) were measured for each lesion.

Results

The number of lesions detected in the study population was 195. Among all diagnosed lesions, 120 (62%) were assessed to be infiltrating cancers, 16 (8%) non-infiltrating cancers, and 59 (30%) were benign. Thirteen (7%) lesions did not enhance in CESM; all non-enhancing lesions were confirmed to be benign under histopathological examination. Analysis of enhancement indices showed that signal values within lesions and signal values within background ROIs (regions of interest) were similar in CC (craniocaudal) and MLO (mediolateral) projections. Mean %RS values were correlated with the type of enhancing lesion, infiltrating cancers having the highest values, benign lesions the lowest.

Conclusions

This work has demonstrated a significant correlation between the degree of lesion enhancement in CESM and malignancy. Quantitative analysis of enhancement levels in CESM can distinguish between invasive cancers and benign or in situ lesions.

Key Points

• There is a possibility of quantitative assessment of contrast enhancement in CESM.

• Correlation between quantitative assessment of contrast enhancement in CESM and histopathology was observed.

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10.

Deng CY, Juan YH, Cheung YC et al (2018) Quantitative analysis of enhanced malignant and benign lesions on contrast-enhanced spectral mammography. Br J Radiol 91:20170605. https://doi.org/10.1259/bjr.20170605 CrossRefPubMedPubMedCentral

Title: Correlation between quantitative assessment of contrast enhancement in contrast-enhanced spectral mammography (CESM) and histopathology—preliminary results
Authors: Wojciech Rudnicki
Sylwia Heinze
Joanna Niemiec
Zbigniew Kojs
Beata Sas-Korczynska
Ed Hendrick
Elzbieta Luczynska
Publication date: 01-11-2019
Publisher: Springer Berlin Heidelberg
Keywords: Breast Cancer
Mammography
Breast Cancer
Mammography
Published in: European Radiology / Issue 11/2019
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-019-06232-6

At a glance: The STEP trials

Springer Medicine

Correlation between quantitative assessment of contrast enhancement in contrast-enhanced spectral mammography (CESM) and histopathology—preliminary results

Abstract

Objectives

Methods

Results

Conclusions

Key Points

At a glance: The STEP trials

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusions

Key Points

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