Skip to main content
Top
Published in: European Radiology 7/2019

Open Access 01-07-2019 | Computed Tomography | Computed Tomography

Multi-detector CT imaging: impact of virtual tube current reduction and sparse sampling on detection of vertebral fractures

Authors: Nico Sollmann, Kai Mei, Dennis M. Hedderich, Christian Maegerlein, Felix K. Kopp, Maximilian T. Löffler, Claus Zimmer, Ernst J. Rummeny, Jan S. Kirschke, Thomas Baum, Peter B. Noël

Published in: European Radiology | Issue 7/2019

Login to get access

Abstract

Purpose

To systematically evaluate the effects of virtual tube current reduction and sparse sampling on image quality and vertebral fracture diagnostics in multi-detector computed tomography (MDCT).

Materials and methods

In routine MDCT scans of 35 patients (80.0% females, 70.6 ± 14.2 years, 65.7% showing vertebral fractures), reduced radiation doses were retrospectively simulated by virtually lowering tube currents and applying sparse sampling, considering 50%, 25%, and 10% of the original tube current and projections, respectively. Two readers evaluated items of image quality and presence of vertebral fractures. Readout between the evaluations in the original images and those with virtually lowered tube currents or sparse sampling were compared.

Results

A significant difference was revealed between the evaluations of image quality between MDCT with virtually lowered tube current and sparse-sampled MDCT (p < 0.001). Sparse-sampled data with only 25% of original projections still showed good to very good overall image quality and contrast of vertebrae as well as minimal artifacts. There were no missed fractures in sparse-sampled MDCT with 50% reduction of projections, and clinically acceptable determination of fracture age was possible in MDCT with 75% reduction of projections, in contrast to MDCT with 50% or 75% virtual tube current reduction, respectively.

Conclusion

Sparse-sampled MDCT provides adequate image quality and diagnostic accuracy for vertebral fracture detection with 50% of original projections in contrast to corresponding MDCT with lowered tube current. Thus, sparse sampling is a promising technique for dose reductions in MDCT that could be introduced in future generations of scanners.

Key Points

• MDCT with a reduction of projection numbers of 50% still showed high diagnostic accuracy without any missed vertebral fractures.
• Clinically acceptable determination of vertebral fracture age was possible in MDCT with a reduction of projection numbers of 75%.
• With sparse sampling, higher reductions in radiation exposure can be achieved without compromised image or diagnostic quality in routine MDCT of the spine as compared to MDCT with reduced tube currents.
Appendix
Available only for authorised users
Literature
1.
go back to reference Cooper C, Atkinson EJ, O'Fallon WM, Melton LJ 3rd (1992) Incidence of clinically diagnosed vertebral fractures: a population-based study in Rochester, Minnesota, 1985-1989. J Bone Miner Res 7:221–227CrossRef Cooper C, Atkinson EJ, O'Fallon WM, Melton LJ 3rd (1992) Incidence of clinically diagnosed vertebral fractures: a population-based study in Rochester, Minnesota, 1985-1989. J Bone Miner Res 7:221–227CrossRef
2.
go back to reference Schousboe JT (2016) Epidemiology of vertebral fractures. J Clin Densitom 19:8–22CrossRef Schousboe JT (2016) Epidemiology of vertebral fractures. J Clin Densitom 19:8–22CrossRef
3.
go back to reference Van der Klift M, De Laet CE, McCloskey EV, Hofman A, Pols HA (2002) The incidence of vertebral fractures in men and women: the Rotterdam Study. J Bone Miner Res 17:1051–1056CrossRef Van der Klift M, De Laet CE, McCloskey EV, Hofman A, Pols HA (2002) The incidence of vertebral fractures in men and women: the Rotterdam Study. J Bone Miner Res 17:1051–1056CrossRef
4.
go back to reference Venkatesan M, Fong A, Sell PJ (2012) CT scanning reduces the risk of missing a fracture of the thoracolumbar spine. J Bone Joint Surg Br 94:1097–1100CrossRefPubMed Venkatesan M, Fong A, Sell PJ (2012) CT scanning reduces the risk of missing a fracture of the thoracolumbar spine. J Bone Joint Surg Br 94:1097–1100CrossRefPubMed
5.
go back to reference Harris TJ, Blackmore CC, Mirza SK, Jurkovich GJ (2008) Clearing the cervical spine in obtunded patients. Spine (Phila Pa 1976) 33:1547–1553CrossRef Harris TJ, Blackmore CC, Mirza SK, Jurkovich GJ (2008) Clearing the cervical spine in obtunded patients. Spine (Phila Pa 1976) 33:1547–1553CrossRef
7.
go back to reference Richards PJ, George J, Metelko M, Brown M (2010) Spine computed tomography doses and cancer induction. Spine (Phila Pa 1976) 35:430–433CrossRef Richards PJ, George J, Metelko M, Brown M (2010) Spine computed tomography doses and cancer induction. Spine (Phila Pa 1976) 35:430–433CrossRef
8.
go back to reference Richards PJ, George J (2010) Diagnostic CT radiation and cancer induction. Skeletal Radiol 39:421–424CrossRefPubMed Richards PJ, George J (2010) Diagnostic CT radiation and cancer induction. Skeletal Radiol 39:421–424CrossRefPubMed
9.
go back to reference Brenner DJ, Hall EJ (2007) Computed tomography--an increasing source of radiation exposure. N Engl J Med 357:2277–2284CrossRef Brenner DJ, Hall EJ (2007) Computed tomography--an increasing source of radiation exposure. N Engl J Med 357:2277–2284CrossRef
10.
go back to reference Gnannt R, Winklehner A, Goetti R, Schmidt B, Kollias S, Alkadhi H (2012) Low kilovoltage CT of the neck with 70 kVp: comparison with a standard protocol. AJNR Am J Neuroradiol 33:1014–1019CrossRef Gnannt R, Winklehner A, Goetti R, Schmidt B, Kollias S, Alkadhi H (2012) Low kilovoltage CT of the neck with 70 kVp: comparison with a standard protocol. AJNR Am J Neuroradiol 33:1014–1019CrossRef
11.
go back to reference Mulkens TH, Marchal P, Daineffe S et al (2007) Comparison of low-dose with standard-dose multidetector CT in cervical spine trauma. AJNR Am J Neuroradiol 28:1444–1450CrossRefPubMed Mulkens TH, Marchal P, Daineffe S et al (2007) Comparison of low-dose with standard-dose multidetector CT in cervical spine trauma. AJNR Am J Neuroradiol 28:1444–1450CrossRefPubMed
12.
go back to reference Becce F, Ben Salah Y, Verdun FR et al (2013) Computed tomography of the cervical spine: comparison of image quality between a standard-dose and a low-dose protocol using filtered back-projection and iterative reconstruction. Skeletal Radiol 42:937–945CrossRef Becce F, Ben Salah Y, Verdun FR et al (2013) Computed tomography of the cervical spine: comparison of image quality between a standard-dose and a low-dose protocol using filtered back-projection and iterative reconstruction. Skeletal Radiol 42:937–945CrossRef
13.
go back to reference Lee SH, Yun SJ, Kim DH, Jo HH, Song JG, Park YS (2017) Diagnostic usefulness of low-dose lumbar multi-detector CT with iterative reconstruction in trauma patients: a comparison with standard-dose CT. Br J Radiol 90:20170181CrossRefPubMedPubMedCentral Lee SH, Yun SJ, Kim DH, Jo HH, Song JG, Park YS (2017) Diagnostic usefulness of low-dose lumbar multi-detector CT with iterative reconstruction in trauma patients: a comparison with standard-dose CT. Br J Radiol 90:20170181CrossRefPubMedPubMedCentral
14.
go back to reference Weinrich JM, Well L, Regier M et al (2018) MDCT in suspected lumbar spine fracture: comparison of standard and reduced dose settings using iterative reconstruction. Clin Radiol 73:675 e679–675 e615CrossRef Weinrich JM, Well L, Regier M et al (2018) MDCT in suspected lumbar spine fracture: comparison of standard and reduced dose settings using iterative reconstruction. Clin Radiol 73:675 e679–675 e615CrossRef
15.
go back to reference Abbas S, Lee T, Shin S, Lee R, Cho S (2013) Effects of sparse sampling schemes on image quality in low-dose CT. Med Phys 40:111915CrossRefPubMed Abbas S, Lee T, Shin S, Lee R, Cho S (2013) Effects of sparse sampling schemes on image quality in low-dose CT. Med Phys 40:111915CrossRefPubMed
16.
go back to reference Mei K, Kopp FK, Bippus R et al (2017) Is multidetector CT-based bone mineral density and quantitative bone microstructure assessment at the spine still feasible using ultra-low tube current and sparse sampling? Eur Radiol 27:5261–5271CrossRefPubMedPubMedCentral Mei K, Kopp FK, Bippus R et al (2017) Is multidetector CT-based bone mineral density and quantitative bone microstructure assessment at the spine still feasible using ultra-low tube current and sparse sampling? Eur Radiol 27:5261–5271CrossRefPubMedPubMedCentral
17.
go back to reference Mookiah MRK, Subburaj K, Mei K et al (2018) Multidetector computed tomography imaging: effect of sparse sampling and iterative reconstruction on trabecular bone microstructure. J Comput Assist Tomogr 42:441–447CrossRef Mookiah MRK, Subburaj K, Mei K et al (2018) Multidetector computed tomography imaging: effect of sparse sampling and iterative reconstruction on trabecular bone microstructure. J Comput Assist Tomogr 42:441–447CrossRef
18.
go back to reference Koesters T, Knoll F, Sodickson A, Sodickson DK, Otazo R (2017) SparseCT: interrupted-beam acquisition and sparse reconstruction for radiation dose reduction. Proc. SPIE 10132, Medical Imaging 2017: Physics of Medical Imaging, 101320Q. https://doi.org/10.1117/12.2255522 Koesters T, Knoll F, Sodickson A, Sodickson DK, Otazo R (2017) SparseCT: interrupted-beam acquisition and sparse reconstruction for radiation dose reduction. Proc. SPIE 10132, Medical Imaging 2017: Physics of Medical Imaging, 101320Q. https://​doi.​org/​10.​1117/​12.​2255522
19.
go back to reference Chen B, Muckley M, Sodickson A et al (2018) First multislit collimator prototype for sparseCT: design, manufacturing and initial validation The Fifth International Conference on Image Formation in X-Ray Computed Tomography, Salt Lake City, pp 52–55 Chen B, Muckley M, Sodickson A et al (2018) First multislit collimator prototype for sparseCT: design, manufacturing and initial validation The Fifth International Conference on Image Formation in X-Ray Computed Tomography, Salt Lake City, pp 52–55
20.
go back to reference Muckley M, Chen B, O’Donnell T et al (2018) Reconstruction of reduced-dose sparseCT data acquired with an interruped-beam prototype On A clinical scanner The Fifth International Conference on Image Formation in X-Ray Computed Tomography, Salt Lake City, pp 56-59 Muckley M, Chen B, O’Donnell T et al (2018) Reconstruction of reduced-dose sparseCT data acquired with an interruped-beam prototype On A clinical scanner The Fifth International Conference on Image Formation in X-Ray Computed Tomography, Salt Lake City, pp 56-59
21.
go back to reference Zabic S, Wang Q, Morton T, Brown KM (2013) A low dose simulation tool for CT systems with energy integrating detectors. Med Phys 40:031102CrossRefPubMed Zabic S, Wang Q, Morton T, Brown KM (2013) A low dose simulation tool for CT systems with energy integrating detectors. Med Phys 40:031102CrossRefPubMed
22.
24.
25.
go back to reference Ramachandran GN, Lakshminarayanan AV (1971) Three-dimensional reconstruction from radiographs and electron micrographs: application of convolutions instead of Fourier transforms. Proc Natl Acad Sci U S A 68:2236–2240CrossRefPubMedPubMedCentral Ramachandran GN, Lakshminarayanan AV (1971) Three-dimensional reconstruction from radiographs and electron micrographs: application of convolutions instead of Fourier transforms. Proc Natl Acad Sci U S A 68:2236–2240CrossRefPubMedPubMedCentral
26.
27.
go back to reference Shrout PE, Fleiss JL (1979) Intraclass correlations: uses in assessing rater reliability. Psychol Bull 86:420–428CrossRef Shrout PE, Fleiss JL (1979) Intraclass correlations: uses in assessing rater reliability. Psychol Bull 86:420–428CrossRef
28.
go back to reference Bartko JJ (1966) The intraclass correlation coefficient as a measure of reliability. Psychol Rep 19:3–11CrossRefPubMed Bartko JJ (1966) The intraclass correlation coefficient as a measure of reliability. Psychol Rep 19:3–11CrossRefPubMed
29.
go back to reference Cohen J (1968) Weighted kappa: nominal scale agreement with provision for scaled disagreement or partial credit. Psychol Bull 70:213–220CrossRef Cohen J (1968) Weighted kappa: nominal scale agreement with provision for scaled disagreement or partial credit. Psychol Bull 70:213–220CrossRef
30.
go back to reference Cohen J (1960) A coefficient of agreement for nominal scales. Educ Psychol Meas 20:37–46CrossRef Cohen J (1960) A coefficient of agreement for nominal scales. Educ Psychol Meas 20:37–46CrossRef
31.
go back to reference Sim J, Wright CC (2005) The kappa statistic in reliability studies: use, interpretation, and sample size requirements. Phys Ther 85:257–268 Sim J, Wright CC (2005) The kappa statistic in reliability studies: use, interpretation, and sample size requirements. Phys Ther 85:257–268
33.
go back to reference Bohy P, de Maertelaer V, Roquigny A, Keyzer C, Tack D, Gevenois PA (2007) Multidetector CT in patients suspected of having lumbar disk herniation: comparison of standard-dose and simulated low-dose techniques. Radiology 244:524–531CrossRefPubMed Bohy P, de Maertelaer V, Roquigny A, Keyzer C, Tack D, Gevenois PA (2007) Multidetector CT in patients suspected of having lumbar disk herniation: comparison of standard-dose and simulated low-dose techniques. Radiology 244:524–531CrossRefPubMed
34.
go back to reference Lee SH, Yun SJ, Jo HH, Kim DH, Song JG, Park YS (2018) Diagnostic accuracy of low-dose versus ultra-low-dose CT for lumbar disc disease and facet joint osteoarthritis in patients with low back pain with MRI correlation. Skeletal Radiol 47:491–504CrossRefPubMed Lee SH, Yun SJ, Jo HH, Kim DH, Song JG, Park YS (2018) Diagnostic accuracy of low-dose versus ultra-low-dose CT for lumbar disc disease and facet joint osteoarthritis in patients with low back pain with MRI correlation. Skeletal Radiol 47:491–504CrossRefPubMed
35.
go back to reference Beister M, Kolditz D, Kalender WA (2012) Iterative reconstruction methods in X-ray CT. Phys Med 28:94–108CrossRefPubMed Beister M, Kolditz D, Kalender WA (2012) Iterative reconstruction methods in X-ray CT. Phys Med 28:94–108CrossRefPubMed
36.
go back to reference Willemink MJ, Leiner T, de Jong PA et al (2013) Iterative reconstruction techniques for computed tomography part 2: initial results in dose reduction and image quality. Eur Radiol 23:1632–1642CrossRefPubMed Willemink MJ, Leiner T, de Jong PA et al (2013) Iterative reconstruction techniques for computed tomography part 2: initial results in dose reduction and image quality. Eur Radiol 23:1632–1642CrossRefPubMed
Metadata
Title
Multi-detector CT imaging: impact of virtual tube current reduction and sparse sampling on detection of vertebral fractures
Authors
Nico Sollmann
Kai Mei
Dennis M. Hedderich
Christian Maegerlein
Felix K. Kopp
Maximilian T. Löffler
Claus Zimmer
Ernst J. Rummeny
Jan S. Kirschke
Thomas Baum
Peter B. Noël
Publication date
01-07-2019
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 7/2019
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-019-06090-2

Other articles of this Issue 7/2019

European Radiology 7/2019 Go to the issue