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Open Access 01-09-2019 | Liver Function Test | Hepatobiliary-Pancreas

Comparison between dynamic gadoxetate-enhanced MRI and ^99mTc-mebrofenin hepatobiliary scintigraphy with SPECT for quantitative assessment of liver function

Authors: F. Rassam, T. Zhang, K. P. Cieslak, C. Lavini, J. Stoker, R. J. Bennink, T. M. van Gulik, L. J. van Vliet, J. H. Runge, F. M. Vos

Published in: European Radiology | Issue 9/2019

Abstract

Objectives

To compare Gd-EOB-DTPA dynamic hepatocyte-specific contrast-enhanced MRI (DHCE-MRI) with ^99mTc-mebrofenin hepatobiliary scintigraphy (HBS) as quantitative liver function tests for the preoperative assessment of patients undergoing liver resection.

Methods

Patients undergoing liver surgery and preoperative assessment of future remnant liver (FRL) function using ^99mTc-mebrofenin HBS were included. Patients underwent DHCE-MRI. Total liver uptake function was calculated for both modalities: mebrofenin uptake rate (MUR) and Ki respectively. The FRL was delineated with both SPECT-CT and MRI to calculate the functional share. Blood samples were taken to assess biochemical liver parameters.

Results

A total of 20 patients were included. The HBS-derived MUR and the DHCE-MRI-derived mean Ki correlated strongly for both total and FRL function (Pearson r = 0.70, p = 0.001 and r = 0.89, p < 0.001 respectively). There was a strong agreement between the functional share determined with both modalities (ICC = 0.944, 95% CI 0.863–0.978, n = 20). There was a significant negative correlation between liver aminotransferases and bilirubin for both MUR and Ki.

Conclusions

Assessment of liver function with DHCE-MRI is comparable with that of ^99mTc-mebrofenin HBS and has the potential to be combined with diagnostic MRI imaging. This can therefore provide a one-stop-shop modality for the preoperative assessment of patients undergoing liver surgery.

Key Points

• Quantitative assessment of liver function using hepatobiliary scintigraphy is performed in the preoperative assessment of patients undergoing liver surgery in order to prevent posthepatectomy liver failure.

• Gd-EOB-DTPA dynamic hepatocyte-specific contrast-enhanced MRI (DHCE-MRI) is an emerging method to quantify liver function and can serve as a potential alternative to hepatobiliary scintigraphy.

• Assessment of liver function with dynamic gadoxetate-enhanced MRI is comparable with that of hepatobiliary scintigraphy and has the potential to be combined with diagnostic MRI imaging.

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Title: Comparison between dynamic gadoxetate-enhanced MRI and 99mTc-mebrofenin hepatobiliary scintigraphy with SPECT for quantitative assessment of liver function
Authors: F. Rassam
T. Zhang
K. P. Cieslak
C. Lavini
J. Stoker
R. J. Bennink
T. M. van Gulik
L. J. van Vliet
J. H. Runge
F. M. Vos
Publication date: 01-09-2019
Publisher: Springer Berlin Heidelberg
Keywords: Liver Function Test
Liver Resection
Liver Resection
Scintigraphy
Published in: European Radiology / Issue 9/2019
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-019-06029-7

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Comparison between dynamic gadoxetate-enhanced MRI and ^99mTc-mebrofenin hepatobiliary scintigraphy with SPECT for quantitative assessment of liver function

Abstract

Objectives

Methods

Results

Conclusions

Key Points

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusions

Key Points

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