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European Radiology
Published in: European Radiology 5/2015

01-05-2015 | Hepatobiliary-Pancreas

Imaging-based evaluation of liver function: comparison of 99mTc-mebrofenin hepatobiliary scintigraphy and Gd-EOB-DTPA-enhanced MRI

Authors: Dominik Geisel, Lutz Lüdemann, Vera Fröling, Maciej Malinowski, Martin Stockmann, Annekathrin Baron, Bernhard Gebauer, Daniel Seehofer, Vikas Prasad, Timm Denecke

Published in: European Radiology | Issue 5/2015

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Abstract

Objectives

To compare Gd-EOB-enhanced MRI and 99mTc-mebrofenin hepatobiliary scintigraphy (HBS) as imaging-based liver function tests for separate evaluation of right (RLL) and left liver lobe (LLL) function.

Methods

Fourteen patients underwent Gd-EOB-enhanced MRI and 99mTc-mebrofenin HBS after portal vein embolization within 24 h. Relative enhancement (RE) and hepatic uptake index (HUI) were determined from MRI; and T max, T 1/2 and mebrofenin uptake were determined from HBS, all values separately for RLL and LLL.

Results

Mebrofenin uptake correlated significantly with HUI and RE for both liver lobes. There was strong correlation of mebrofenin uptake with HUI for RLL (r 2 = 0.802, p = 0.001) and RE for LLL (r 2 = 0.704, p = 0.005) and moderate correlation with HUI for LLL (r 2 = 0.560, p = 0.037) and RE for RLL (r 2 = 0.620, p = 0.018). Correlating the percentage share of RLL function derived from MRI (with HUI) with the percentage of RLL function derived from mebrofenin uptake revealed a strong correlation (r 2 = 0.775, p = 0.002).

Conclusions

Both RE and HUI correlate with mebrofenin uptake in HBS. The results suggest that Gd-EOB-enhanced MRI and 99mTc-mebrofenin HBS may equally be used to separately determine right and left liver lobe function.

Key points

• Information about liver function can be acquired with routine Gd-EOB-MRI.
• Gd-EOB-MRI and 99m Tc-mebrofenin HBS show elevated function of non-embolized lobe.
• Gd-EOB-MRI and 99m Tc-mebrofenin HBS can determine lobar liver function.
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Metadata
Title
Imaging-based evaluation of liver function: comparison of 99mTc-mebrofenin hepatobiliary scintigraphy and Gd-EOB-DTPA-enhanced MRI
Authors
Dominik Geisel
Lutz Lüdemann
Vera Fröling
Maciej Malinowski
Martin Stockmann
Annekathrin Baron
Bernhard Gebauer
Daniel Seehofer
Vikas Prasad
Timm Denecke
Publication date
01-05-2015
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 5/2015
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-014-3536-8

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