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European Radiology
Published in: European Radiology 6/2019

Open Access 01-06-2019 | Diabetes | Cardiac

MR extracellular volume mapping and non-contrast T1ρ mapping allow early detection of myocardial fibrosis in diabetic monkeys

Authors: Yu Zhang, Wen Zeng, Wei Chen, Yushu Chen, Tong Zhu, Jiayu Sun, Zhigang Liang, Wei Cheng, Lei Wang, Bing Wu, Li Gong, Victor A. Ferrari, Jie Zheng, Fabao Gao

Published in: European Radiology | Issue 6/2019

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Abstract

Objective

To detect diffuse myocardial fibrosis in different severity levels of left ventricular diastolic dysfunction (DD) in spontaneous type 2 diabetes mellitus (T2DM) rhesus monkeys.

Methods

Eighteen spontaneous T2DM and nine healthy monkeys were studied. Echocardiography was performed for diastolic function classification. Cardiac magnetic resonance (CMR) imaging was performed to obtain extracellular volume fraction (ECV) maps and T1ρ maps at two different spin-locking frequencies. ECV values, T1ρ values, and myocardial fibrosis index (mFI) values which are based on the dispersion of T1ρ, were calculated. Global peak diastolic longitudinal strain rates (GSrL) were also obtained.

Results

Echocardiography results showed mild DD in nine T2DM monkeys and moderate DD in the other nine. The global ECV values were significantly different among healthy animals as compared with animals with mild DD or moderate DD, and the ECV values of animals with moderate DD were significantly higher as compared with those of mild DD. The mFI values increased progressively from healthy animals to those with mild DD and then to those with moderate DD. Diastolic function indicators (e.g., early diastolic mitral annulus velocity, GSrL) correlated well with ECV and mFI.

Conclusions

Monkeys with T2DM exhibit increased ECV, T1ρ, and mFI values, which may be indicative of the expansion of extracellular volume and the deposition of excessive collagen. T1ρ mapping may have the potential to be used for diffuse myocardial fibrosis assessment.

Key Points

• Monkeys with T2DM exhibit increased ECV, T1ρ, and mFI values, which may be indicative of the expansion of extracellular volume and the deposition of excessive collagen.
• The relationship between diastolic dysfunction and diffuse myocardial fibrosis may be demonstrated by imaging markers.
• Non-contrast T1ρ mapping may have the potential to be used for diffuse myocardial assessment.
Appendix
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Metadata
Title
MR extracellular volume mapping and non-contrast T1ρ mapping allow early detection of myocardial fibrosis in diabetic monkeys
Authors
Yu Zhang
Wen Zeng
Wei Chen
Yushu Chen
Tong Zhu
Jiayu Sun
Zhigang Liang
Wei Cheng
Lei Wang
Bing Wu
Li Gong
Victor A. Ferrari
Jie Zheng
Fabao Gao
Publication date
01-06-2019
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 6/2019
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-018-5950-9

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