Top

Published in:

Open Access 01-08-2019 | Experimental

Time-series hyperpolarized xenon-129 MRI of lobar lung ventilation of COPD in comparison to V/Q-SPECT/CT and CT

Authors: Ozkan Doganay, Tahreema Matin, Mitchell Chen, Minsuok Kim, Anthony McIntyre, Daniel R. McGowan, Kevin M. Bradley, Thomas Povey, Fergus V. Gleeson

Published in: European Radiology | Issue 8/2019

Abstract

Purpose

To derive lobar ventilation in patients with chronic obstructive pulmonary disease (COPD) using a rapid time-series hyperpolarized xenon-129 (HPX) magnetic resonance imaging (MRI) technique and compare this to ventilation/perfusion single-photon emission computed tomography (V/Q-SPECT), correlating the results with high-resolution computed tomography (CT) and pulmonary function tests (PFTs).

Materials and methods

Twelve COPD subjects (GOLD stages I–IV) participated in this study and underwent HPX-MRI, V/Q-SPECT/CT, high-resolution CT, and PFTs. HPX-MRI was performed using a novel time-series spiral k-space sampling approach. Relative percentage ventilations were calculated for individual lobe for comparison to the relative SPECT lobar ventilation and perfusion. The absolute HPX-MRI percentage ventilation in each lobe was compared to the absolute CT percentage emphysema score calculated using a signal threshold method. Pearson’s correlation and linear regression tests were performed to compare each imaging modality.

Results

Strong correlations were found between the relative lobar percentage ventilation with HPX-MRI and percentage ventilation SPECT (r = 0.644; p < 0.001) and percentage perfusion SPECT (r = 0.767; p < 0.001). The absolute CT percentage emphysema and HPX percentage ventilation correlation was also statistically significant (r = 0.695, p < 0.001). The whole lung HPX percentage ventilation correlated with the PFT measurements (FEV₁ with r = − 0.886, p < 0.001*, and FEV₁/FVC with r = − 0.861, p < 0.001*) better than the whole lung CT percentage emphysema score (FEV₁ with r = − 0.635, p = 0.027; and FEV₁/FVC with r = − 0.652, p = 0.021).

Conclusion

Lobar ventilation with HPX-MRI showed a strong correlation with lobar ventilation and perfusion measurements derived from SPECT/CT, and is better than the emphysema score obtained with high-resolution CT.

Key Points

• The ventilation hyperpolarized xenon-129 MRI correlates well with ventilation and perfusion with SPECT/CT with the advantage of higher temporal and spatial resolution.

• The hyperpolarized xenon-129 MRI correlates with the PFT measurements better than the high-resolution CT with the advantage of avoiding the use of ionizing radiation.

Available only for authorised users

Lopez AD, Shibuya K, Rao C et al (2006) Chronic obstructive pulmonary disease: current burden and future projections. Eur Respir J 27:397–412CrossRefPubMed

Adeloye D, Chua S, Lee C et al (2015) Global and regional estimates of COPD prevalence: systematic review and meta-analysis. J Glob Health 5:020415CrossRefPubMedPubMedCentral

Matin TN, Rahman N, Nickol AH et al (2017) Chronic obstructive pulmonary disease: lobar analysis with hyperpolarized 129Xe MR imaging. Radiology 282:857–868CrossRefPubMed

Matsuoka S, Kurihara Y, Yagihashi K, Hoshino M, Nakajima Y (2008) Airway dimensions at inspiratory and expiratory multisection CT in chronic obstructive pulmonary disease: correlation with airflow limitation. Radiology 248:1042–1049CrossRefPubMed

Litmanovich D, Boiselle PM, Bankier AA (2009) CT of pulmonary emphysema--current status, challenges, and future directions. Eur Radiol 19:537–551CrossRefPubMed

Heussel CP, Herth FJ, Kappes J et al (2009) Fully automatic quantitative assessment of emphysema in computed tomography: comparison with pulmonary function testing and normal values. Eur Radiol 19:2391–2402CrossRefPubMed

Coxson HO, Dirksen A, Edwards LD et al (2013) The presence and progression of emphysema in COPD as determined by CT scanning and biomarker expression: a prospective analysis from the ECLIPSE study. Lancet Respir Med 1:129–136CrossRefPubMed

Froeling V, Heimann U, Huebner RH et al (2015) Ventilation/perfusion SPECT or SPECT/CT for lung function imaging in patients with pulmonary emphysema? Ann Nucl Med 29:528–534

De Backer JW, Vos WG, Vinchurkar SC et al (2010) Validation of computational fluid dynamics in CT-based airway models with SPECT/CT. Radiology 257:854–862CrossRefPubMed

10.

Jogi J, Markstad H, Tufvesson E, Bjermer L, Bajc M (2015) The added value of hybrid ventilation/perfusion SPECT/CT in patients with stable COPD or apparently healthy smokers. Cancer-suspected CT findings in the lungs are common when hybrid imaging is used. Int J Chron Obstruct Pulmon Dis 10:25–30PubMed

11.

Bajc M, Chen Y, Wang J et al (2017) Identifying the heterogeneity of COPD by V/P SPECT: a new tool for improving the diagnosis of parenchymal defects and grading the severity of small airways disease. Int J Chron Obstruct Pulmon Dis 12:1579–1587CrossRefPubMedPubMedCentral

12.

Ax M, Karlsson LL, Sánchez-Crespo A et al (2013) Regional lung ventilation in humans during hypergravity studied with quantitative SPECT. Respir Physiol Neurobiol 189:558–564CrossRefPubMed

13.

Petersson J, Rohdin M, Sánchez-Crespo A et al (2006) Paradoxical redistribution of pulmonary blood flow in prone and supine humans exposed to hypergravity. J Appl Physiol (1985) 100:240–248CrossRef

14.

Petersson J, Sánchez-Crespo A, Rohdin M et al (2004) Physiological evaluation of a new quantitative SPECT method measuring regional ventilation and perfusion. J Appl Physiol (1985) 96:1127–1136CrossRef

15.

Petersson J, Sánchez-Crespo A, Larsson SA, Mure M (2007) Physiological imaging of the lung: single-photon-emission computed tomography (SPECT). J Appl Physiol (1985) 102:468–476CrossRef

16.

Parraga G, Ouriadov A, Evans A et al (2007) Hyperpolarized 3He ventilation defects and apparent diffusion coefficients in chronic obstructive pulmonary disease: preliminary results at 3.0 Tesla. Invest Radiol 42:384–391CrossRefPubMed

17.

Swift AJ, Wild JM, Fichele S et al (2005) Emphysematous changes and normal variation in smokers and COPD patients using diffusion 3He MRI. Eur J Radiol 54:352–358CrossRefPubMed

18.

Driehuys B, Martinez-Jimenez S, Cleveland ZI et al (2012) Chronic obstructive pulmonary disease: safety and tolerability of hyperpolarized 129Xe MR imaging in healthy volunteers and patients. Radiology 262:279–289CrossRefPubMedPubMedCentral

19.

Virgincar RS, Cleveland ZI, Kaushik SS et al (2013) Quantitative analysis of hyperpolarized 129Xe ventilation imaging in healthy volunteers and subjects with chronic obstructive pulmonary disease. NMR Biomed 26:424–435CrossRefPubMed

20.

Kirby M, Pike D, Sin DD, Coxson HO, McCormack DG, Parraga G (2015) COPD: do imaging measurements of emphysema and airway disease explain symptoms and exercise capacity? Radiology 277:872–880CrossRefPubMed

21.

Stewart NJ, Chan HF, Hughes PJC et al (2018) Comparison of (3) He and (129) Xe MRI for evaluation of lung microstructure and ventilation at 1.5T. J Magn Reson Imaging. https://doi.org/10.1002/jmri.25992

22.

Kirby M, Ouriadov A, Svenningsen S et al (2014) Hyperpolarized 3He and 129Xe magnetic resonance imaging apparent diffusion coefficients: physiological relevance in older never- and ex-smokers. Physiol Rep 2(7):e12068

23.

Svenningsen S, Kirby M, Starr D et al (2013) Hyperpolarized (3) He and (129) Xe MRI: differences in asthma before bronchodilation. J Magn Reson Imaging 38:1521–1530CrossRefPubMed

24.

Voskrebenzev A, Gutberlet M, Klimeš F et al (2017) Feasibility of quantitative regional ventilation and perfusion mapping with phase-resolved functional lung (PREFUL) MRI in healthy volunteers and COPD, CTEPH, and CF patients. Magn Reson Med. https://doi.org/10.1002/mrm.26893

25.

Kruger SJ, Nagle SK, Couch MJ, Ohno Y, Albert M, Fain SB (2016) Functional imaging of the lungs with gas agents. J Magn Reson Imaging 43:295–315CrossRefPubMed

26.

Tahir BA, Swift AJ, Marshall H et al (2014) A method for quantitative analysis of regional lung ventilation using deformable image registration of CT and hybrid hyperpolarized gas/1H MRI. Phys Med Biol 59:7267–7277CrossRefPubMed

27.

Tahir BA, Van Holsbeke C, Ireland RH et al (2015) Comparison of CT-based lobar ventilation with he MR imaging ventilation measurements. Radiology https://doi.org/10.1148/radiol.2015142278:142278

28.

Pike D, Kirby M, Eddy RL et al (2016) Regional heterogeneity of chronic obstructive pulmonary disease phenotypes: pulmonary (3)He magnetic resonance imaging and computed tomography. COPD 13:601–609CrossRefPubMed

29.

Qing K, Tustison NJ, Mugler JP 3rd et al (2018) Probing changes in lung physiology in COPD using CT, perfusion MRI, and hyperpolarized xenon-129 MRI. Acad Radiol. https://doi.org/10.1016/j.acra.2018.05.025

30.

Stavngaard T, Søgaard LV, Mortensen J et al (2005) Hyperpolarized 3He MRI and 81mKr SPECT in chronic obstructive pulmonary disease. Eur J Nucl Med Mol Imaging 32:448–457CrossRefPubMed

31.

Meersmann T, Brunner E (2015) Hyperpolarized xenon-129 magnetic resonance: concepts, production, techniques and applications, 1st edn. Royal Society of Chemistry, Cambridge

32.

Doganay O, Matin TN, McIntyre A et al (2018) Fast dynamic ventilation MRI of hyperpolarized (129) Xe using spiral imaging. Magn Reson Med 79:2597–2606CrossRefPubMed

33.

Xiao S, Deng H, Duan C et al (2018) Considering low-rank, sparse and gas-inflow effects constraints for accelerated pulmonary dynamic hyperpolarized (129)Xe MRI. J Magn Reson 290:29–37CrossRefPubMed

34.

Yushkevich PA, Piven J, Hazlett HC et al (2006) User-guided 3D active contour segmentation of anatomical structures: significantly improved efficiency and reliability. Neuroimage 31:1116–1128CrossRef

35.

Doganay O, Thind K, Wade T, Ouriadov A, Santyr GE (2015) Transmit-only/receive-only radiofrequency coil configuration for hyperpolarized Xe-129 MRI of rat lungs. Concepts Magn Reson Part B Magn Reson Eng 45:115–124CrossRef

36.

Xu X, Norquay G, Parnell SR et al (2012) Hyperpolarized 129Xe gas lung MRI-SNR and T2* comparisons at 1.5 T and 3 T. Magn Reson Med 68:1900–1904CrossRefPubMed

37.

38.

Kirby M, Svenningsen S, Kanhere N et al (2013) Pulmonary ventilation visualized using hyperpolarized helium-3 and xenon-129 magnetic resonance imaging: differences in COPD and relationship to emphysema. J Appl Physiol (1985) 114:707–715CrossRef

39.

Kirby M, Svenningsen S, Owrangi A et al (2012) Hyperpolarized ³He and ¹²⁹Xe MR imaging in healthy volunteers and patients with chronic obstructive pulmonary disease. Radiology 265:600–610CrossRefPubMed

40.

Owrangi AM, Etemad-Rezai R, McCormack DG, Cunningham IA, Parraga G (2013) Computed tomography density histogram analysis to evaluate pulmonary emphysema in ex-smokers. Acad Radiol 20:537–545CrossRefPubMed

41.

Sverzellati N, Molinari F, Pirronti T, Bonomo L, Spagnolo P, Zompatori M (2007) New insights on COPD imaging via CT and MRI. Int J Chron Obstruct Pulmon Dis 2:301–312PubMedPubMedCentral

42.

Yahaba M, Kawata N, Iesato K et al (2014) The effects of emphysema on airway disease: correlations between multi-detector CT and pulmonary function tests in smokers. Eur J Radiol 83:1022–1028CrossRefPubMed

43.

Grydeland TB, Dirksen A, Coxson HO et al (2009) Quantitative computed tomography: emphysema and airway wall thickness by sex, age and smoking. Eur Respir J 34:858–865CrossRefPubMed

44.

Schroeder JD, McKenzie AS, Zach JA et al (2013) Relationships between airflow obstruction and quantitative CT measurements of emphysema, air trapping, and airways in subjects with and without chronic obstructive pulmonary disease. AJR Am J Roentgenol 201:W460–W470CrossRefPubMedPubMedCentral

Title: Time-series hyperpolarized xenon-129 MRI of lobar lung ventilation of COPD in comparison to V/Q-SPECT/CT and CT
Authors: Ozkan Doganay
Tahreema Matin
Mitchell Chen
Minsuok Kim
Anthony McIntyre
Daniel R. McGowan
Kevin M. Bradley
Thomas Povey
Fergus V. Gleeson
Publication date: 01-08-2019
Publisher: Springer Berlin Heidelberg
Published in: European Radiology / Issue 8/2019
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-018-5888-y

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Time-series hyperpolarized xenon-129 MRI of lobar lung ventilation of COPD in comparison to V/Q-SPECT/CT and CT

Abstract

Purpose

Materials and methods

Results

Conclusion

Key Points

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Purpose

Materials and methods

Results

Conclusion

Key Points

Please log in to get access to this content

Other articles of this Issue 8/2019

Comparison between M-score and LR-M in the reporting system of contrast-enhanced ultrasound LI-RADS

The efficacy of fluoroscopy-guided epidural blood patch in the treatment of spontaneous and iatrogenic cerebrospinal fluid leakage

MRI radiomics analysis for predicting preoperative synchronous distant metastasis in patients with rectal cancer

Liver microwave ablation: a systematic review of various FDA-approved systems

Radiomic analysis of imaging heterogeneity in tumours and the surrounding parenchyma based on unsupervised decomposition of DCE-MRI for predicting molecular subtypes of breast cancer

Initial exploration of coronary stent image subtraction using dual-layer spectral CT