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Open Access 01-10-2018 | Oncology

Oesophageal squamous cell carcinoma: histogram-derived ADC parameters are not predictive of tumour response to chemoradiotherapy

Authors: Maiko Kozumi, Hideki Ota, Takaya Yamamoto, Rei Umezawa, Haruo Matsushita, Yojiro Ishikawa, Noriyoshi Takahashi, Tomonori Matsuura, Kei Takase, Keiichi Jingu

Published in: European Radiology | Issue 10/2018

Abstract

Objectives

To evaluate correlations between tumour response to definitive chemoradiotherapy (CRT) in oesophageal squamous cell carcinoma (SCC) and histogram-derived apparent diffusion coefficient (ADC) parameters on diffusion-weighted MR images.

Methods

Forty patients with clinical T3–4 oesophageal SCC underwent concurrent CRT. MR examination at 3 T was performed 1–3 days prior to CRT. Readout-segmented echo-planar diffusion imaging was used to acquire ADC maps. Pre- and post-treatment CT examinations were performed. Histogram parameters (mean, 10th, 25th, 50th, 75th, 90th percentiles, skewness and kurtosis) of the ADC values were compared with post-treatment disease status based on RECIST and the tumour regression ratio.

Results

None of the ADC parameters showed significant correlation with post-treatment status (range of Spearman’s ρ values − 0.19 to 0.14, range of p values 0.22–0.47) or tumour regression ratio (range of Spearman’s ρ values − 0.045 to 0.18, range of p values 0.26–0.96). Neither progression-free survival (PFS) (p = 0.17) nor overall survival (OS) (p = 0.15) was significantly different between the two groups corresponding to the lower (< median) and upper arms (≥ median) of the mean ADC values.

Conclusions

Histogram-derived pretreatment ADC parameters were not predictive imaging biomarkers for tumour response to CRT in patients with oesophageal SCC.

Key Points

• Apparent diffusion coefficient (ADC) values are derived from diffusion-weighted MR imaging.

• High-resolution diffusion-weighted images are generated by readout-segmented echo-planar diffusion imaging.

• Readout-segmented echo-planar diffusion-weighted imaging enabled evaluation of ADC parameters.

• Pretreatment ADC parameters do not predict chemoradiotherapy response in patients with oesophageal carcinoma.

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Title: Oesophageal squamous cell carcinoma: histogram-derived ADC parameters are not predictive of tumour response to chemoradiotherapy
Authors: Maiko Kozumi
Hideki Ota
Takaya Yamamoto
Rei Umezawa
Haruo Matsushita
Yojiro Ishikawa
Noriyoshi Takahashi
Tomonori Matsuura
Kei Takase
Keiichi Jingu
Publication date: 01-10-2018
Publisher: Springer Berlin Heidelberg
Published in: European Radiology / Issue 10/2018
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-018-5439-6

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Oesophageal squamous cell carcinoma: histogram-derived ADC parameters are not predictive of tumour response to chemoradiotherapy

Abstract

Objectives

Methods

Results

Conclusions

Key Points

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusions

Key Points

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