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European Radiology
Published in: European Radiology 5/2011

01-05-2011 | Gastrointestinal

Apparent diffusion coefficient for evaluating tumour response to neoadjuvant chemoradiation therapy for locally advanced rectal cancer

Authors: Seung Ho Kim, Jae Young Lee, Jeong Min Lee, Joon Koo Han, Byung Ihn Choi

Published in: European Radiology | Issue 5/2011

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Abstract

Objective

To determine whether change in the apparent diffusion coefficient (ADC) before and after neoadjuvant chemoradiation therapy (CRT) for locally advanced rectal cancer (LARC) would more accurately predict pathological complete response (pCR) than analysing the pre- or post-CRT ADC individually.

Methods

76 patients with LARC (≥T3 or lymph node-positive) underwent pre- and post-CRT, 1.5-T diffusion-weighted imaging. A blinded radiologist measured the tumour ADCs. The three measures were compared with regard to CR and non-CR. To calculate accuracy for determining pCR, receiver-operating characteristic curve (ROC) analysis was applied to the three measures.

Results

The post-CRT ADC (1.43 ± 0.10) (×10−3 mm2/s) and the percentage change (70.0 ± 23.5%) in the CR (n = 11) were significantly higher than those in the non-CR (n = 65) (1.14 ± 0.18, 30.2 ± 21.7%, respectively)(both, P < 0.0001). The pre-CRT ADC (0.85 ± 0.10) of the pCR did not differ significantly from that of the non-pCR (0.88 ± 0.14)(P = 0.4094). The post-CRT ADC showed comparable relative accuracy for determining pCR to that of the percentage change (P = 0.788). However, overall accuracy of the former (87%) was higher than that of the latter (75%) (P = 0.049).

Conclusion

Analyzing post-CRT ADC alone can reliably differentiate pCR from non-pCR in LARC
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Metadata
Title
Apparent diffusion coefficient for evaluating tumour response to neoadjuvant chemoradiation therapy for locally advanced rectal cancer
Authors
Seung Ho Kim
Jae Young Lee
Jeong Min Lee
Joon Koo Han
Byung Ihn Choi
Publication date
01-05-2011
Publisher
Springer-Verlag
Published in
European Radiology / Issue 5/2011
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-010-1989-y

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