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European Radiology
Published in: European Radiology 5/2018

01-05-2018 | Chest

Pulmonary subsolid nodules: value of semi-automatic measurement in diagnostic accuracy, diagnostic reproducibility and nodule classification agreement

Authors: Hyungjin Kim, Chang Min Park, Eui Jin Hwang, Su Yeon Ahn, Jin Mo Goo

Published in: European Radiology | Issue 5/2018

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Abstract

Objectives

We hypothesized that semi-automatic diameter measurements would improve the accuracy and reproducibility in discriminating preinvasive lesions and minimally invasive adenocarcinomas from invasive pulmonary adenocarcinomas appearing as subsolid nodules (SSNs) and increase the reproducibility in classifying SSNs.

Methods

Two readers independently performed semi-automatic and manual measurements of the diameters of 102 SSNs and their solid portions. Diagnostic performance in predicting invasive adenocarcinoma based on diameters was tested using logistic regression analysis with subsequent receiver operating characteristic curves. Inter- and intrareader reproducibilities of diagnosis and SSN classification according to Fleischner’s guidelines were investigated for each measurement method using Cohen’s κ statistics.

Results

Semi-automatic effective diameter measurements were superior to manual average diameters for the diagnosis of invasive adenocarcinoma (AUC, 0.905–0.923 for semi-automatic measurement and 0.833–0.864 for manual measurement; p<0.05). Reproducibility of diagnosis between the readers also improved with semi-automatic measurement (κ=0.924 for semi-automatic measurement and 0.690 for manual measurement, p=0.012). Inter-reader SSN classification reproducibility was significantly higher with semi-automatic measurement (κ=0.861 for semi-automatic measurement and 0.683 for manual measurement, p=0.022).

Conclusions

Semi-automatic effective diameter measurement offers an opportunity to improve diagnostic accuracy and reproducibility as well as the classification reproducibility of SSNs.

Key Points

• Semi-automatic effective diameter measurement improves the diagnostic accuracy for pulmonary subsolid nodules.
• Semi-automatic measurement increases the inter-reader agreement on the diagnosis for subsolid nodules.
• Semi-automatic measurement augments the inter-reader reproducibility for the classification of subsolid nodules.
Appendix
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Metadata
Title
Pulmonary subsolid nodules: value of semi-automatic measurement in diagnostic accuracy, diagnostic reproducibility and nodule classification agreement
Authors
Hyungjin Kim
Chang Min Park
Eui Jin Hwang
Su Yeon Ahn
Jin Mo Goo
Publication date
01-05-2018
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 5/2018
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-017-5171-7

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