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01-05-2018 | Computed Tomography

Tin-filtered low-dose chest CT to quantify macroscopic calcification burden of the thoracic aorta

Authors: Christoph Schabel, Daniele Marin, Dominik Ketelsen, Alfredo E. Farjat, Georg Bier, Mario Lescan, Fabian Bamberg, Konstantin Nikolaou, Malte N. Bongers

Published in: European Radiology | Issue 5/2018

Abstract

Objectives

To compare a low-dose, tin-filtered, nonenhanced, high-pitch Sn100 kVp CT protocol (Sn100) with a standard protocol (STP) for the detection of calcifications in the ascending aorta in patients scheduled for cardiac surgery.

Methods

Institutional Review Board approval for this retrospective study was waived and the study was HIPAA-compliant. The study included 192 patients (128 men; age 68.8 ± 9.9 years), of whom 87 received the STP and 105 the Sn100 protocol. Size-specific dose estimates (SSDE) and radiation doses were obtained using dose monitoring software. Two blinded readers evaluated image quality on a scale from 1 (low) to 5 (high) and the extent of calcifications of the ascending aorta on a scale from 0 (none) to 10 (high), subdivided into 12 anatomic segments.

Results

The Sn100 protocol achieved a mean SSDE of only 0.5 ± 0.1 mGy and 0.20 ± 0.04 mSv compared with the mean SSDE of 5.4 ± 2.2 mGy achieved with the STP protocol (p < 0.0001). Calcification burden was associated with age (p < 0.0001), but was independent of protocol with mean calcification scores of 0.48 ± 1.23 (STP) and 0.55 ± 1.25 (Sn100, p = 0.18). Reader agreement was very good (STP κ = 0.87 ± 0.02, Sn100 κ = 0.88 ± 0.01). The STP protocol provided a higher subjective image quality than the Sn100 protocol: STP median 4, interquartile range 4–5, vs. SN100 3, 3–4; p < 0.0001) and a slightly better depiction of calcification (STP 5, 4–5, vs. Sn100 4, 4–5; p < 0.0001).

Conclusions

The optimized Sn100 protocol achieved a mean SSDE of only 0.5 ± 0.1 mGy while the depiction of calcifications remained good, and there was no systematic difference in calcification burden between the two protocols.

Key points

• Tin-filtered, low-dose CT can be used to assess aortic calcifications before cardiac surgery

• An optimized Sn100 protocol achieved a mean SSDE of only 0.5 ± 0.1 mGy

• The depiction of atherosclerosis of the thoracic aorta was similar with both protocols

• The depiction of relevant thoracic pathologies before cardiac surgery was similar with both protocols

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Title: Tin-filtered low-dose chest CT to quantify macroscopic calcification burden of the thoracic aorta
Authors: Christoph Schabel
Daniele Marin
Dominik Ketelsen
Alfredo E. Farjat
Georg Bier
Mario Lescan
Fabian Bamberg
Konstantin Nikolaou
Malte N. Bongers
Publication date: 01-05-2018
Publisher: Springer Berlin Heidelberg
Published in: European Radiology / Issue 5/2018
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-017-5168-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Tin-filtered low-dose chest CT to quantify macroscopic calcification burden of the thoracic aorta

Abstract

Objectives

Methods

Results

Conclusions

Key points

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusions

Key points

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