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01-12-2016 | Chest

Software performance in segmenting ground-glass and solid components of subsolid nodules in pulmonary adenocarcinomas

Authors: Julien G. Cohen, Jin Mo Goo, Roh-Eul Yoo, Chang Min Park, Chang Hyun Lee, Bram van Ginneken, Doo Hyun Chung, Young Tae Kim

Published in: European Radiology | Issue 12/2016

Abstract

Objective

To evaluate the performance of software in segmenting ground-glass and solid components of subsolid nodules in pulmonary adenocarcinomas.

Method

Seventy-three pulmonary adenocarcinomas manifesting as subsolid nodules were included. Two radiologists measured the maximal axial diameter of the ground-glass components on lung windows and that of the solid components on lung and mediastinal windows. Nodules were segmented using software by applying five (-850 HU to -650 HU) and nine (-130 HU to -500 HU) attenuation thresholds. We compared the manual and software measurements of ground-glass and solid components with pathology measurements of tumour and invasive components.

Results

Segmentation of ground-glass components at a threshold of -750 HU yielded mean differences of +0.06 mm (p = 0.83, 95 % limits of agreement, 4.51 to 4.67) and -2.32 mm (p < 0.001, -8.27 to 3.63) when compared with pathology and manual measurements, respectively. For solid components, mean differences between the software (at -350 HU) and pathology measurements and between the manual (lung and mediastinal windows) and pathology measurements were -0.12 mm (p = 0.74, -5.73 to 5.55]), 0.15 mm (p = 0.73, -6.92 to 7.22), and -1.14 mm (p < 0.001, -7.93 to 5.64), respectively.

Conclusion

Software segmentation of ground-glass and solid components in subsolid nodules showed no significant difference with pathology.

Key Points

• Software can effectively segment ground-glass and solid components in subsolid nodules.

• Software measurements show no significant difference with pathology measurements.

• Manual measurements are more accurate on lung windows than on mediastinal windows.

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Title: Software performance in segmenting ground-glass and solid components of subsolid nodules in pulmonary adenocarcinomas
Authors: Julien G. Cohen
Jin Mo Goo
Roh-Eul Yoo
Chang Min Park
Chang Hyun Lee
Bram van Ginneken
Doo Hyun Chung
Young Tae Kim
Publication date: 01-12-2016
Publisher: Springer Berlin Heidelberg
Published in: European Radiology / Issue 12/2016
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-016-4317-3

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Software performance in segmenting ground-glass and solid components of subsolid nodules in pulmonary adenocarcinomas

Abstract

Objective

Method

Results

Conclusion

Key Points

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Objective

Method

Results

Conclusion

Key Points

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