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European Radiology

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Open Access 01-05-2018 | Magnetic Resonance

Sensitivity to change and association of three-dimensional meniscal measures with radiographic joint space width loss in rapid clinical progression of knee osteoarthritis

Authors: Melanie Roth, Katja Emmanuel, Wolfgang Wirth, C. Kent Kwoh, David J. Hunter, Felix Eckstein

Published in: European Radiology | Issue 5/2018

Abstract

Objective

To determine whether 3D meniscal measures had similar sensitivity to longitudinal change as cartilage thickness; to what extent these measures are associated with longitudinal joint space width (JSW) change; and whether the latter associations differ between minimum (mJSW) and fixed-location JSW.

Methods

Two-year changes in medial meniscal position and morphology, cartilage thickness (MRI) and minimum and fixed-location JSW (radiography) were determined in 35 Osteoarthritis Initiative knees [12 men, age: 67 (51-77) years; 23 women, age: 65 (54-78) years], progressing from baseline Kellgren-Lawrence grade ≤2 to knee replacement within 3-5 years. Multiple linear regression assessed the features contributing to JSW change.

Results

Meniscal measures, cartilage thickness and JSW displayed similar sensitivity to change (standardised response mean≤|0.76|). Meniscal changes were strongly associated with JSW change (r≤|0.66|), adding ≤20% to its variance in addition to cartilage thickness change. Fixed-location JSW change (multiple r²=72%) was more strongly related to cartilage and meniscal change than mJSW (61%). Meniscal morphology explained more of fixed-location JSW and meniscal position more of mJSW.

Conclusion

Meniscal measures provide independent information in explaining the variance of radiographic JSW change. Fixed-location JSW appears to be more reflective of structural change than mJSW and, hence, a potentially superior measure of structural progression.

Key Points

• 3D positional/morphological meniscal measures change in rapidly progressing knees.

• Similar sensitivity to 2-year change of quantitative meniscal/cartilage measures in rapid progression.

• Changes in meniscal measures are strongly associated with radiographic JSW change.

• Meniscal change provides information to explain JSW variance independent of cartilage.

• Fixed-location JSW reflects structural disease stage more closely than minimum JSW.

Conaghan PG, Hunter DJ, Maillefert JF, Reichmann WM, Losina E (2011) Summary and recommendations of the OARSI FDA osteoarthritis Assessment of Structural Change Working Group. Osteoarthritis Cartilage 19:606–610CrossRefPubMedPubMedCentral

Eckstein F, Boudreau R, Wang Z et al (2016) Comparison of radiographic joint space width and magnetic resonance imaging for prediction of knee replacement: a longitudinal case-control study from the Osteoarthritis Initiative. Eur Radiol 26:1942–1951CrossRefPubMed

Bloecker K, Wirth W, Hunter DJ et al (2013) Contribution of regional 3D meniscus and cartilage morphometry by MRI to joint space width in fixed flexion knee radiography--a between-knee comparison in subjects with unilateral joint space narrowing. Eur J Radiol 82:e832–e839CrossRefPubMed

Hunter DJ, Zhang YQ, Tu X et al (2006) Change in joint space width: hyaline articular cartilage loss or alteration in meniscus? Arthritis Rheum 54:2488–2495CrossRefPubMed

Gale DR, Chaisson CE, Totterman SM, Schwartz RK, Gale ME, Felson D (1999) Meniscal subluxation: association with osteoarthritis and joint space narrowing. Osteoarthr Cartil 7:526–532CrossRefPubMed

Hunter DJ, Buck R, Vignon E et al (2009) Relation of regional articular cartilage morphometry and meniscal position by MRI to joint space width in knee radiographs. Osteoarthr Cartil 17:1170–1176CrossRefPubMed

Adams JG, McAlindon T, Dimasi M, Carey J, Eustace S (1999) Contribution of meniscal extrusion and cartilage loss to joint space narrowing in osteoarthritis. Clin Radiol 54:502–506CrossRefPubMed

Beattie KA, Duryea J, Pui M et al (2008) Minimum joint space width and tibial cartilage morphology in the knees of healthy individuals: a cross-sectional study. BMC Musculoskelet Disord 9:119CrossRefPubMedPubMedCentral

Neumann G, Hunter D, Nevitt M et al (2009) Location specific radiographic joint space width for osteoarthritis progression. Osteoarthr Cartil 17:761–765CrossRefPubMed

10.

Wirth W, Duryea J, Hellio Le Graverand M-PP et al (2013) Direct comparison of fixed flexion, radiography and MRI in knee osteoarthritis: responsiveness data from the Osteoarthritis Initiative. Osteoarthr Cartil 21:117–125CrossRefPubMed

11.

Duryea J, Neumann G, Niu J et al (2010) Comparison of radiographic joint space width with magnetic resonance imaging cartilage morphometry: analysis of longitudinal data from the Osteoarthritis Initiative. Arthritis Care Res 62:932–937CrossRef

12.

Wirth W, Nevitt M, Hellio Le Graverand MP et al (2013) Lateral and medial joint space narrowing predict subsequent cartilage loss in the narrowed, but not in the non-narrowed femorotibial compartment - data from the osteoarthritis initiative. Osteoarthr Cartil 22:63–70CrossRefPubMedPubMedCentral

13.

Wirth W, Frobell RB, Souza RB et al (2010) A three-dimensional quantitative method to measure meniscus shape, position, and signal intensity using MR images: a pilot study and preliminary results in knee osteoarthritis. Magn Reson 63:1162–1171CrossRef

14.

Siorpaes K, Wenger A, Bloecker K, Wirth W, Hudelmaier M, Eckstein F (2012) Interobserver reproducibility of quantitative meniscus analysis using coronal multiplanar DESS and IWTSE MR imaging. Magn Reson 67:1419–1426CrossRef

15.

Bloecker K, Englund M, Wirth W et al (2011) Revision 1 size and position of the healthy meniscus, and its correlation with sex, height, weight, and bone area- a cross-sectional study. BMC Musculoskelet Disord 12:248CrossRefPubMedPubMedCentral

16.

Roth M, Wirth W, Emmanuel K, Culvenor A, Eckstein F (2017) The contribution of 3D meniscus and cartilage measures to normal radiographic joint space width - data from the Osteoarthritis Initiative healthy reference cohort. Eur J Radiol 87:90–98CrossRefPubMed

17.

Bloecker K, Wirth W, Guermazi A, Hitzl W, Hunter DJ, Eckstein F (2015) Longitudinal change in quantitative meniscus measurements in knee osteoarthritis-data from the Osteoarthritis Initiative. Eur Radiol 25:2960–2968CrossRefPubMed

18.

Eckstein F, Wirth W, Nevitt MC (2012) Recent advances in osteoarthritis imaging-the Osteoarthritis Initiative. Nat Rev Rheumatol 8:622–630CrossRefPubMed

19.

Peterfy CG, Schneider E, Nevitt M (2008) The osteoarthritis initiative: report on the design rationale for the magnetic resonance imaging protocol for the knee. Osteoarthr Cart 16:1433–1441CrossRef

20.

Schneider E, NessAiver M, White D et al (2008) The osteoarthritis initiative (OAI) magnetic resonance imaging quality assurance methods and results. Osteoarthritis Cartilage 16:994–1004CrossRefPubMedPubMedCentral

21.

Eckstein F, Kwoh CK, Boudreau R et al (2013) Quantitative magnetic resonance imaging measures of cartilage predict knee replacement - a case-control study from the Osteoarthritis Initiative. Ann Rheum Dis 72:707–714CrossRefPubMed

22.

Eckstein F, Boudreau RM, Wang Z et al (2014) Trajectory of cartilage loss within 4 years of knee replacement - a nested case-control study from the Osteoarthritis Initiative. Osteoarthr Cartil 22:1542–1549CrossRefPubMedPubMedCentral

23.

Synarc (2006) MRI procedure manual for examinations of the knee and thigh osteoarthritis initiative: a knee health study PROTOCOL: osteoarthritis initiative: a knee health study

24.

Wirth W, Duryea JW, Nevitt MC, Buck RJ, Hunter D, Eckstein F (2013) Sensitivity to change of radiographic fixed-location and magnetic resonance imaging-based cartilage thickness measures in the lateral compartment of knees with radiographic osteoarthritis – data from the osteoarthritis initiative. Arthritis Rheum 65:S481

25.

Wirth W, Eckstein F (2008) A technique for regional analysis of femorotibial cartilage thickness based on quantitative magnetic resonance imaging. IEEE Trans Med Imaging 27:737–744CrossRefPubMed

26.

Eckstein F, Ateshian G, Burgkart R et al (2006) Proposal for a nomenclature for magnetic resonance imaging based measures of articular cartilage in osteoarthritis. Osteoarthr Cartil 14:974–983CrossRefPubMed

27.

Efron B, Tibshirani RJ (1994) An Introduction to the Bootstrap. CRC Press, Boca Raton

28.

Bloecker K, Wirth W, Guermazi A et al (2015) Relationship Between Medial Meniscal Extrusion and Cartilage Loss in Specific Femorotibial Subregions: Data From the Osteoarthritis Initiative. Arthritis Care Res 67:1545–1552CrossRef

29.

Wenger A, Wirth W, Hudelmaier M et al (2013) Meniscus body position, size, and shape in persons with and persons without radiographic knee osteoarthritis: quantitative analyses of knee magnetic resonance images from the osteoarthritis initiative. Arthritis Rheum 65:1804–1811CrossRefPubMed

30.

Jung KA, Lee SC, Hwang SH et al (2009) High frequency of meniscal hypertrophy in persons with advanced varus knee osteoarthritis. Rheumatol Int 30:1325–1333CrossRefPubMed

Title: Sensitivity to change and association of three-dimensional meniscal measures with radiographic joint space width loss in rapid clinical progression of knee osteoarthritis
Authors: Melanie Roth
Katja Emmanuel
Wolfgang Wirth
C. Kent Kwoh
David J. Hunter
Felix Eckstein
Publication date: 01-05-2018
Publisher: Springer Berlin Heidelberg
Published in: European Radiology / Issue 5/2018
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-017-5140-1

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Sensitivity to change and association of three-dimensional meniscal measures with radiographic joint space width loss in rapid clinical progression of knee osteoarthritis

Abstract

Objective

Methods

Results

Conclusion

Key Points

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Springer Medicine

Abstract

Objective

Methods

Results

Conclusion

Key Points

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