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European Radiology

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01-10-2015 | Musculoskeletal

Longitudinal change in quantitative meniscus measurements in knee osteoarthritis—data from the Osteoarthritis Initiative

Authors: Katja Bloecker, W. Wirth, A. Guermazi, W. Hitzl, D. J. Hunter, F. Eckstein

Published in: European Radiology | Issue 10/2015

Abstract

Objective

We aimed to apply 3D MRI-based measurement technology to studying 2-year change in quantitative measurements of meniscus size and position.

Methods

Forty-seven knees from the Osteoarthritis Initiative with medial radiographic joint space narrowing had baseline and 2-year follow-up MRIs. Quantitative measures were obtained from manual segmentation of the menisci and tibia using coronal DESSwe images. The standardized response mean (SRM = mean/SD change) was used as measure of sensitivity to longitudinal change.

Results

Medial tibial plateau coverage decreased from 34.8 % to 29.9 % (SRM -0.82; p < 0.001). Change in medial meniscus extrusion in a central image (SRM 0.18) and in the central five slices (SRM 0.22) did not reach significance, but change in extrusion across the entire meniscus (SRM 0.32; p = 0.03) and in the relative area of meniscus extrusion (SRM 0.56; p < 0.001) did. There was a reduction in medial meniscus volume (10 %; p < 0.001), width (7 %; p < 0.001), and height (2 %; p = 0.08); meniscus substance loss was strongest in the posterior (SRM -0.51; p = 0.001) and weakest in the anterior horn (SRM -0.15; p = 0.31).

Conclusion

This pilot study reports, for the first time, longitudinal change in quantitative 3D meniscus measurements in knee osteoarthritis. It provides evidence of improved sensitivity to change of 3D measurements compared with single slice analysis.

Key Points

• First longitudinal MRI-based measurements of change of meniscus position and size.

• Quantitative longitudinal evaluation of meniscus change in knee osteoarthritis.

• Improved sensitivity to change of 3D measurements compared with single slice analysis.

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Bloecker K, Guermazi A, Wirth W, Benichou O, Kwoh CK, Hunter DJ, Englund M, Resch H, Eckstein F (2012) Tibial coverage, meniscus position, size and damage in knees discordant for joint space narrowing - data from the Osteoarthritis Initiative. Osteoarthr Cartil

Title: Longitudinal change in quantitative meniscus measurements in knee osteoarthritis—data from the Osteoarthritis Initiative
Authors: Katja Bloecker
W. Wirth
A. Guermazi
W. Hitzl
D. J. Hunter
F. Eckstein
Publication date: 01-10-2015
Publisher: Springer Berlin Heidelberg
Published in: European Radiology / Issue 10/2015
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-015-3710-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Longitudinal change in quantitative meniscus measurements in knee osteoarthritis—data from the Osteoarthritis Initiative

Abstract

Objective

Methods

Results

Conclusion

Key Points

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Methods

Results

Conclusion

Key Points

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