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Open Access 01-04-2018 | Gastrointestinal

Secretin-stimulated ultrasound estimation of pancreatic secretion in cystic fibrosis validated by magnetic resonance imaging

Authors: Trond Engjom, Erling Tjora, Gaute Wathle, Friedemann Erchinger, Birger N. Lærum, Odd H. Gilja, Ingfrid Salvesen Haldorsen, Georg Dimcevski

Published in: European Radiology | Issue 4/2018

Abstract

Objectives

Secretin-stimulated magnetic resonance imaging (s-MRI) is the best validated radiological modality assessing pancreatic secretion. The purpose of this study was to compare volume output measures from secretin-stimulated transabdominal ultrasonography (s-US) to s-MRI for the diagnosis of exocrine pancreatic failure in cystic fibrosis (CF).

Methods

We performed transabdominal ultrasonography and MRI before and at timed intervals during 15 minutes after secretin stimulation in 21 CF patients and 13 healthy controls. To clearly identify the subjects with reduced exocrine pancreatic function, we classified CF patients as pancreas-sufficient or -insufficient by secretin-stimulated endoscopic short test and faecal elastase.

Results

Pancreas-insufficient CF patients had reduced pancreatic secretions compared to pancreas-sufficient subjects based on both imaging modalities (p < 0.001). Volume output estimates assessed by s-US correlated to that of s-MRI (r = 0.56–0.62; p < 0.001). Both s-US (AUC: 0.88) and s-MRI (AUC: 0.99) demonstrated good diagnostic accuracy for exocrine pancreatic failure.

Conclusions

Pancreatic volume-output estimated by s-US corresponds well to exocrine pancreatic function in CF patients and yields comparable results to that of s-MRI. s-US provides a simple and feasible tool in the assessment of pancreatic secretion.

Key points

• Cystic fibrosis patients with affected pancreas have reduced pancreatic secretions.

• Secretin-stimulated sonography is a simple and feasible method to assess pancreatic output.

• Secretin-simulated MRI is a more precise method to assess pancreatic secretions.

• The sonographic and MRI methods yielded comparable pancreatic secretory output estimates.

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Title: Secretin-stimulated ultrasound estimation of pancreatic secretion in cystic fibrosis validated by magnetic resonance imaging
Authors: Trond Engjom
Erling Tjora
Gaute Wathle
Friedemann Erchinger
Birger N. Lærum
Odd H. Gilja
Ingfrid Salvesen Haldorsen
Georg Dimcevski
Publication date: 01-04-2018
Publisher: Springer Berlin Heidelberg
Published in: European Radiology / Issue 4/2018
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-017-5115-2

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Secretin-stimulated ultrasound estimation of pancreatic secretion in cystic fibrosis validated by magnetic resonance imaging

Abstract

Objectives

Methods

Results

Conclusions

Key points

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusions

Key points

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