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01-12-2016 | Hepatobiliary-Pancreas

Postprandial changes in secretory flow of pancreatic juice in the main pancreatic duct: evaluation with cine-dynamic MRCP with a spatially selective inversion-recovery (IR) pulse

Authors: Kazuya Yasokawa, Katsuyoshi Ito, Tsutomu Tamada, Akira Yamamoto, Minoru Hayashida, Teruyuki Torigoe, Daigo Tanimoto, Atsushi Higaki, Yasufumi Noda, Ayumu Kido

Published in: European Radiology | Issue 12/2016

Abstract

Purpose

To evaluate the influence of oral ingestion on the secretory flow dynamics of physiological pancreatic juice within the main pancreatic duct in healthy subjects by using cine-dynamic MRCP with spatially-selective inversion-recovery (IR) pulse non-invasively.

Materials and methods

Thirty-eight healthy subjects were investigated. MRCP with spatially-selective IR pulse was repeated every 15 s for 5 min to acquire a total of 20 images (cine-dynamic MRCP). A set of 20 MRCP images was repeatedly obtained before and after liquid oral ingestion every 7 min (including 2-min interval) for 40 min (a total of seven sets). Secretion grade of pancreatic juice on cine-dynamic MRCP was compared before and after oral ingestion using the nonparametric Wilcoxon signed-rank test.

Results

Median secretion grades of pancreatic juice at 5 min (score = 2.15), 12 min (score = 1.95) and 19 min (score = 2.05) after ingestion were significantly higher than that before ingestion (score = 1.40) (P = 0.004, P = 0.032, P = 0.045, respectively). Secretion grade of pancreatic juice showed a maximum peak of 2.15 at 5 min after ingestion. Thereafter, the secretion grade of pancreatic juice tended to gradually decline.

Conclusion

Non-invasive cine-dynamic MRCP using spatially-selective IR pulse showed potential for evaluating postprandial changes in the secretory flow dynamics of pancreatic juice as a physiological reaction.

Key Points

• Secretion grade of pancreatic juice at cine-dynamic MRCP after ingestion was evaluated.

• Secretion grade was significantly increased within 19 min after liquid meal ingestion.

• Secretion grade showed maximum peak of 2.15 at 5 min after ingestion.

• Postprandial changes in pancreatic juice flow can be assessed by cine-dynamic MRCP.

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Title: Postprandial changes in secretory flow of pancreatic juice in the main pancreatic duct: evaluation with cine-dynamic MRCP with a spatially selective inversion-recovery (IR) pulse
Authors: Kazuya Yasokawa
Katsuyoshi Ito
Tsutomu Tamada
Akira Yamamoto
Minoru Hayashida
Teruyuki Torigoe
Daigo Tanimoto
Atsushi Higaki
Yasufumi Noda
Ayumu Kido
Publication date: 01-12-2016
Publisher: Springer Berlin Heidelberg
Published in: European Radiology / Issue 12/2016
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-016-4287-5

At a glance: The STEP trials

Springer Medicine

Postprandial changes in secretory flow of pancreatic juice in the main pancreatic duct: evaluation with cine-dynamic MRCP with a spatially selective inversion-recovery (IR) pulse

Abstract

Purpose

Materials and methods

Results

Conclusion

Key Points

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Materials and methods

Results

Conclusion

Key Points

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