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European Radiology
Published in: European Radiology 1/2018

01-01-2018 | Urogenital

Assessment of acute kidney injury with T1 mapping MRI following solid organ transplantation

Authors: Matti Peperhove, Van Dai Vo Chieu, Mi-Sun Jang, Marcel Gutberlet, Dagmar Hartung, Susanne Tewes, Gregor Warnecke, Christiane Fegbeutel, Axel Haverich, Wilfried Gwinner, Frank Lehner, Jan Hinrich Bräsen, Hermann Haller, Frank Wacker, Faikah Gueler, Katja Hueper

Published in: European Radiology | Issue 1/2018

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Abstract

Objectives

To evaluate T1 mapping as a non-invasive, functional MRI biomarker in patients shortly after solid organ transplantation to detect acute postsurgical kidney damage and to correlate T1 times with renal function.

Methods

101 patients within 2 weeks after solid organ transplantation (49 kidney transplantation, 52 lung transplantation) and 14 healthy volunteers were examined by MRI between July 2012 and April 2015 using the modified Look–Locker inversion recovery (MOLLI) sequence. T1 times in renal cortex and medulla and the corticomedullary difference were compared between groups using one-way ANOVA adjusted for multiple comparison with the Tukey test, and T1 times were correlated with renal function using Pearson’s correlation.

Results

Compared to healthy volunteers T1 times were significantly increased after solid organ transplantation in the renal cortex (healthy volunteers 987 ± 102 ms; kidney transplantation 1299 ± 101 ms, p < 0.001; lung transplantation 1058 ± 96 ms, p < 0.05) and to a lesser extent in the renal medulla. Accordingly, the corticomedullary difference was diminished shortly after solid organ transplantation. T1 changes were more pronounced following kidney compared to lung transplantation, were associated with the stage of renal impairment and significantly correlated with renal function.

Conclusions

T1 mapping may be helpful for early non-invasive assessment of acute kidney injury and renal pathology following major surgery such as solid organ transplantation.

Key Points

• Renal cortical T1 relaxation times are prolonged after solid organ transplantation.
• Cortical T1 values increase with higher stages of renal function impairment.
• Corticomedullary difference decreases with higher stages of renal function impairment.
• Renal cortical T1 relaxation time and corticomedullary difference correlate with renal function.
• T1 mapping may be helpful for non-invasive assessment of post-operative renal pathology.
Literature
1.
Rocha PN, Rocha AT, Palmer SM, Davis RD, Smith SR (2005) Acute renal failure after lung transplantation: incidence, predictors and impact on perioperative morbidity and mortality. Am J Transplant 5:1469–1476CrossRefPubMed
2.
Arnaoutakis GJ, George TJ, Robinson CW et al (2011) Severe acute kidney injury according to the RIFLE (risk, injury, failure, loss, end stage) criteria affects mortality in lung transplantation. J Heart Lung Transplant 30:1161–1168CrossRefPubMedPubMedCentral
3.
Wehbe E, Brock R, Budev M et al (2012) Short-term and long-term outcomes of acute kidney injury after lung transplantation. J Heart Lung Transplant 31:244–251CrossRefPubMed
4.
Li X, Hassoun HT, Santora R, Rabb H (2009) Organ crosstalk: the role of the kidney. Curr Opin Crit Care 15:481–487CrossRefPubMed
5.
Basile DP (2007) The endothelial cell in ischemic acute kidney injury: implications for acute and chronic function. Kidney Int 72:151–156CrossRefPubMed
6.
Sutton TA, Molitoris BA (1998) Mechanisms of cellular injury in ischemic acute renal failure. Semin Nephrol 18:490–497PubMed
7.
Leung KC, Tonelli M, James MT (2013) Chronic kidney disease following acute kidney injury-risk and outcomes. Nat Rev Nephrol 9:77–85CrossRefPubMed
8.
9.
Chawla LS, Eggers PW, Star RA, Kimmel PL (2014) Acute kidney injury and chronic kidney disease as interconnected syndromes. N Engl J Med 371:58–66CrossRefPubMed
10.
Cavaille-Coll M, Bala S, Velidedeoglu E et al (2013) Summary of FDA workshop on ischemia reperfusion injury in kidney transplantation. Am J Transplant 13:1134–1148CrossRefPubMed
11.
McCullough PA, Shaw AD, Haase M et al (2013) Diagnosis of acute kidney injury using functional and injury biomarkers: workgroup statements from the tenth Acute Dialysis Quality Initiative Consensus Conference. Contrib Nephrol 182:13–29CrossRefPubMed
12.
Hueper K, Peperhove M, Rong S et al (2014) T1-mapping for assessment of ischemia-induced acute kidney injury and prediction of chronic kidney disease in mice. Eur Radiol 24:2252–2260CrossRefPubMed
13.
de Miguel MH, Yeung HN, Goyal M et al (1994) Evaluation of quantitative magnetic resonance imaging as a noninvasive technique for measuring renal scarring in a rabbit model of antiglomerular basement membrane disease. J Am Soc Nephrol 4:1861–1868PubMed
14.
Lee VS, Kaur M, Bokacheva L et al (2007) What causes diminished corticomedullary differentiation in renal insufficiency? J Magn Reson Imaging 25:790–795CrossRefPubMed
15.
Huang Y, Sadowski EA, Artz NS et al (2011) Measurement and comparison of T1 relaxation times in native and transplanted kidney cortex and medulla. J Magn Reson Imaging 33:1241–1247CrossRefPubMedPubMedCentral
16.
Hueper K, Khalifa AA, Brasen JH et al (2016) Diffusion-Weighted imaging and diffusion tensor imaging detect delayed graft function and correlate with allograft fibrosis in patients early after kidney transplantation. J Magn Reson Imaging 44:112–121CrossRefPubMed
17.
Levin A, Stevens PE (2014) Summary of KDIGO 2012 CKD Guideline: behind the scenes, need for guidance, and a framework for moving forward. Kidney Int 85:49–61CrossRefPubMed
18.
Hueper K, Gueler F, Brasen JH et al (2015) Functional MRI detects perfusion impairment in renal allografts with delayed graft function. Am J Physiol Ren Physiol 308:F1444–F1451CrossRef
19.
Kiricuta IC Jr, Simplaceanu V (1975) Tissue water content and nuclear magnetic resonance in normal and tumor tissues. Cancer Res 35:1164–1167PubMed
20.
Kundel HL, Schlakman B, Joseph PM, Fishman JE, Summers R (1986) Water content and NMR relaxation time gradients in the rabbit kidney. Investig Radiol 21:12–17CrossRef
21.
de Bazelaire CM, Duhamel GD, Rofsky NM, Alsop DC (2004) MR imaging relaxation times of abdominal and pelvic tissues measured in vivo at 3.0 T: preliminary results. Radiology 230:652–659CrossRefPubMed
22.
Hueper K, Hensen B, Gutberlet M et al (2016) Kidney transplantation: multiparametric functional magnetic resonance imaging for assessment of renal allograft pathophysiology in mice. Investig Radiol 51:58–65CrossRef
23.
Breidthardt T, Cox EF, Squire I et al (2015) The pathophysiology of the chronic cardiorenal syndrome: a magnetic resonance imaging study. Eur Radiol 25:1684–1691CrossRefPubMed
24.
Semelka RC, Corrigan K, Ascher SM, Brown JJ, Colindres RE (1994) Renal corticomedullary differentiation: observation in patients with differing serum creatinine levels. Radiology 190:149–152CrossRefPubMed
25.
Lee KS, Munoz A, Baez AB, Ngo L, Rofsky NM, Pedrosa I (2012) Corticomedullary differentiation on T1-Weighted MRI: comparison between cirrhotic and noncirrhotic patients. J Magn Reson Imaging 35:644–649CrossRefPubMed
26.
Kanki A, Ito K, Tamada T et al (2013) Corticomedullary differentiation of the kidney: evaluation with noncontrast-enhanced steady-state free precession (SSFP) MRI with time-spatial labeling inversion pulse (time-SLIP). J Magn Reson Imaging 37:1178–1181CrossRefPubMed
27.
Hricak H, Terrier F, Demas BE (1986) Renal allografts: evaluation by MR imaging. Radiology 159:435–441CrossRefPubMed
Metadata
Title
Assessment of acute kidney injury with T1 mapping MRI following solid organ transplantation
Authors
Matti Peperhove
Van Dai Vo Chieu
Mi-Sun Jang
Marcel Gutberlet
Dagmar Hartung
Susanne Tewes
Gregor Warnecke
Christiane Fegbeutel
Axel Haverich
Wilfried Gwinner
Frank Lehner
Jan Hinrich Bräsen
Hermann Haller
Frank Wacker
Faikah Gueler
Katja Hueper
Publication date
01-01-2018
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 1/2018
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-017-4943-4

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