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European Radiology
Published in: European Radiology 1/2018

01-01-2018 | Magnetic Resonance

A semiquantitative MRI-Score can predict loss of lung function in patients with cystic fibrosis: Preliminary results

Authors: Juergen F. Schaefer, Andreas Hector, Katharina Schmidt, Matthias Teufel, Sabrina Fleischer, Ute Graepler-Mainka, Joachim Riethmueller, Sergios Gatidis, Susanne Schaefer, Konstantin Nikolaou, Dominik Hartl, Ilias Tsiflikas

Published in: European Radiology | Issue 1/2018

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Abstract

Objectives

To evaluate the applicability of a semiquantitative MRI scoring system (MR-CF-S) as a prognostic marker for clinical course of cystic fibrosis (CF) lung disease.

Methods

This observational study of a single-centre CF cohort included a group of 61 patients (mean age 12.9 ± 4.7 years) receiving morphological and functional pulmonary MRI, pulmonary function testing (PFT) and follow-up of 2 years. MRI was analysed by three raters using MR-CF-S. The inter-rater agreement, correlation of score categories with forced expiratory volume in 1 s (FEV1) at baseline, and the predictive value of clinical parameters, and score categories was assessed for the whole cohort and a subgroup of 40 patients with moderately impaired lung function.

Results

The inter-rater agreement of MR-CF-S was sufficient (mean intraclass correlation coefficient 0.92). MR-CF-S (−0.62; p < 0.05) and most of the categories significantly correlated with FEV1. Differences between patients with relevant loss of FEV1 (>3%/year) and normal course were only significant for MR-CF-S (p < 0.05) but not for clinical parameters. Centrilobular opacity (CO) was the most promising score category for prediction of a decline of FEV1 (area under curve: whole cohort 0.69; subgroup 0.86).

Conclusions

MR-CF-S is promising to predict a loss of lung function. CO seems to be a particular finding in CF patients with an abnormal course.

Key Points

• Lung imaging is essential in the diagnostic work-up of CF patients
• MRI serves as a powerful, radiation-free modality in paediatric CF patients
• Observational single-centre study showed significant correlation of MR-CF score and FEV 1
• MR-CF score is promising in predicting a loss of lung function
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Metadata
Title
A semiquantitative MRI-Score can predict loss of lung function in patients with cystic fibrosis: Preliminary results
Authors
Juergen F. Schaefer
Andreas Hector
Katharina Schmidt
Matthias Teufel
Sabrina Fleischer
Ute Graepler-Mainka
Joachim Riethmueller
Sergios Gatidis
Susanne Schaefer
Konstantin Nikolaou
Dominik Hartl
Ilias Tsiflikas
Publication date
01-01-2018
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 1/2018
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-017-4870-4

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