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European Radiology
Published in: European Radiology 10/2017

01-10-2017 | Urogenital

Selection for biopsy of kidney transplant patients by diffusion-weighted MRI

Authors: Philipp Steiger, Sebastiano Barbieri, Anja Kruse, Michael Ith, Harriet C. Thoeny

Published in: European Radiology | Issue 10/2017

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Abstract

Objectives

To assess retrospectively whether diffusion-weighted magnetic resonance imaging (DW-MRI) allows physicians to determine the severity of histopathologic findings in biopsies of renal allograft patients with deteriorating renal function.

Methods

Forty consecutive kidney transplant patients underwent DW-MRI and biopsy. Patients were assigned to one group with severe and to another group with normal or mild histopathologic findings. These two groups were compared based on a qualitative DW-MRI assessment (homo-/heterogeneity) and the combination of qualitative and quantitative DW-MRI parameters (ADC, and intravoxel incoherent motion, IVIM, parameters: D, f, D*). Sensitivity, specificity, and accuracy were determined for each parameter.

Results

Biopsy findings were severe in 25 patients and normal or mild in 15 patients. Qualitative DW-MRI led to a sensitivity of 44.0% and a specificity of 93.3%. Combined qualitative and quantitative DW-MRI led to an accuracy of 80% for both the minimal ADC (ADCmin) and the minimal perfusion fraction (fmin) with a sensitivity of 84.0% and 92.0% and a specificity of 73.3% and 60.0%, respectively.

Conclusion

Combined qualitative and quantitative DW-MRI might allow physicians to determine the severity of histopathologic findings in biopsies of a high number of kidney transplant patients.

Key points

• Qualitative DW-MRI is highly specific when predicting the severity of kidney transplant biopsy.
• Allografts appearing heterogeneous on ADC are associated with severe histopathologic findings.
• Combining qualitative and quantitative DW-MRI parameters improves the classification’s sensitivity and accuracy.
• Kidney transplant biopsies might be spared by combining qualitative and quantitative DW-MRI.
Appendix
Available only for authorised users
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Metadata
Title
Selection for biopsy of kidney transplant patients by diffusion-weighted MRI
Authors
Philipp Steiger
Sebastiano Barbieri
Anja Kruse
Michael Ith
Harriet C. Thoeny
Publication date
01-10-2017
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 10/2017
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-017-4814-z

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