Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
European Radiology
Published in: European Radiology 6/2010

01-06-2010 | Urogenital

Quantification of renal allograft perfusion using arterial spin labeling MRI: initial results

Authors: Rotem S. Lanzman, Hans-Jörg Wittsack, Petros Martirosian, Panagiota Zgoura, Philip Bilk, Patric Kröpil, Fritz Schick, Adina Voiculescu, Dirk Blondin

Published in: European Radiology | Issue 6/2010

Login to get access

Abstract

Objective

To quantify renal allograft perfusion in recipients with stable allograft function and acute decrease in allograft function using nonenhanced flow-sensitive alternating inversion recovery (FAIR)-TrueFISP arterial spin labeling (ASL) MR imaging.

Methods

Following approval of the local ethics committee, 20 renal allograft recipients were included in this study. ASL perfusion measurement and an anatomical T2-weighted single-shot fast spin-echo (HASTE) sequence were performed on a 1.5-T scanner (Magnetom Avanto, Siemens, Erlangen, Germany). T2-weighted MR urography was performed in patients with suspected ureteral obstruction. Patients were assigned to three groups: group a, 6 patients with stable allograft function over the previous 4 months; group b, 7 patients with good allograft function who underwent transplantation during the previous 3 weeks; group c, 7 allograft recipients with an acute deterioration of renal function.

Results

Mean cortical perfusion values were 304.8 ± 34.4, 296.5 ± 44.1, and 181.9 ± 53.4 mg/100 ml/min for groups a, b and c, respectively. Reduction in cortical perfusion in group c was statistically significant.

Conclusion

Our results indicate that ASL is a promising technique for nonenhanced quantification of cortical perfusion of renal allografts. Further studies are required to determine the clinical value of ASL for monitoring renal allograft recipients.
Literature
1.
Leichtman AB, Cohen D, Keith D et al (2008) Kidney and pancreas transplantation in the United States, 1997–2006: the HRSA breakthrough collaboratives and the 58 DSA challenge. Am J Transplant 8:946–957CrossRefPubMed
2.
3.
Lanzman RS, Voiculescu A, Walther C et al (2009) ECG-gated nonenhanced 3D steady-state free precession (SSFP) MR angiography (MRA) in assessment of transplant renal arteries: comparison with digital substraction angiography (DSA). Radiology 252:914–921CrossRefPubMed
4.
Blondin D, Koester A, Andersen K, Kurz KD, Moedder U, Cohnen M (2009) Renal transplant failure due to urological complications: comparison of static fluid with contrast-enhanced magnetic resonance urography. Eur J Radiol 69:300–307CrossRefPubMed
5.
Sadowski EA, Fain SB, Alford SK et al (2005) Assessment of acute renal transplant rejection with blood oxygen level-dependent MR imaging: initial experience. Radiology 236:911–919CrossRefPubMed
6.
Thoeny HC, Zumstein D, Simon-Zoula S et al (2006) Functional evaluation of transplanted kidneys with diffusion-weighted and BOLD MR imaging: initial experience. Radiology 241:812–821CrossRefPubMed
7.
Beckmann M, Joergensen J, Bruttel K, Rudin M, Schuurman HJ (1996) Magnetic resonance imaging for the evaluation of rejection of kidney allograft in the rat. Transplant Int 9:175–183
8.
Schuurman HJ, Beckmann N, Briner U, Bruns C, Bruttel K, Tanner M, Tolcsvai L, Weckbecker G (1996) Magnetic resonance imaging in assessment of rejection of a kidney allograft in the rat: effect of the somatostatin analogue SMS 201–995. Transplant Proc 28:3272–3275PubMed
9.
Szolar DH, Preidler K, Ebner F et al (1997) Functional magnetic resonance imaging of human renal allografts during the post-transplant period: preliminary observations. Magn Reson Imaging 15:727–735CrossRefPubMed
10.
Preidler KW, Szolar D, Schreyer H, Ebner F, Kern R, Holzer H, Horina JH (1996) Differentiation of delayed kidney graft function with gadolinium-DTPA-enhanced magnetic resonance imaging and doppler ultrasound. Invest Radiol 31:364–371CrossRefPubMed
11.
Sadowski EA, Benett LK, Chan MR (2007) Nephrogenic systemic fibrosis: risk factors and incidence estimation. Radiology 243:148–157CrossRefPubMed
12.
Golay X, Hendrikse J, Lim TC (2004) Perfusion imaging using arterial spin labeling. Top Magn Reson Imaging 15:10–27CrossRefPubMed
13.
Karger N, Biederer J, Lüsse S, Grimm J, Steffens JC, Heller M, Glüer CC (2000) Quantitation of renal perfusion with arterial spin labeling with FAIR-UFLARE. Magn Reson Imaging 18:641–647CrossRefPubMed
14.
Boss A, Martirosian P, Claussen CD, Schick F (2006) Quantitative ASL muscle perfusion imaging using a FAIR-TrueFISP technique at 3.0 T. NMR Biomed 19:125–132CrossRefPubMed
15.
Schwenzer NF, Schraml C, Martirosian P, Boss A, Claussen CD, Schick F (2008) MR measurement of blood flow in the parotid gland without contrast medium: a functional study before and after gustatory stimulation. NMR Biomed 21:598–605CrossRefPubMed
16.
Martirosian P, Klose U, Mader I, Schick F (2004) FAIR True-FISP perfusion imaging of the kidneys. Magn Reson Med 51:353–361CrossRefPubMed
17.
Huang Y, Artz N, Wen Z, Sadowski E, Fain S (2009) Measurement and comparison of T1 relaxation time in native and transplanted kidney cortex. In: Proceedings of the seventeenth meeting of the International Society for Magnetic Resonance in Medicine, Honolulu, Hawai, p 2041
18.
Roberts DA, Detre JA, Bolinger L, Insko EK, Lenkinski RE, Pentecost MJ, Leigh JS (1995) Renal perfusion in humans: MR imaging with spin tagging of arterial water. Radiology 196:281–286PubMed
19.
Fenchel M, Martirosian P, Langanke J et al (2006) Perfusion imaging with FAIR TrueFISP spin labeling in patients with and without renal artery stenosis: initial experience. Radiology 238:1013–1021CrossRefPubMed
20.
Hariharan S, Johnson C, Bresnahan BA, Taranto SE, McIntosh MJ, Stablein D (2000) Improved graft survival after renal transplantation in the United States, 1988 to 1996. N Engl J Med 342:605–612CrossRefPubMed
21.
Thoeny HC, Kessler TM, Simon-Zoula S, De Keyzer F, Mohaupt M, Studer UE, Vermathen P (2008) Renal oxygenation changes during acute unilateral ureteral obstruction: assessment with blood oxygen level-dependent MR imaging—initial experience. Radiology 247:754–761CrossRefPubMed
22.
Loo MH, Felsen D, Weisman S, Marion DN, Vaughan ED (1988) Pathophysiology of obstructive uropathy. World J Urol 6:53CrossRef
23.
Sheehan SJ, Moran KT, Dowsett DJ, Fitzpatrick JM (1994) Renal haemodynamics and prostaglandin synthesis in partial unilateral ureteric obstruction. Urol Res 22:279–285CrossRefPubMed
24.
Bruno S, Remuzzi G, Ruggenenti P (2004) Transplant renal artery stenosis. J Am Soc Nephrol 15:134–141CrossRefPubMed
25.
Lin YR, Wu MT, Huang TY et al (2004) Comparison of arterial spin labeling and first-pass dynamic contrast-enhanced MR imaging in the assessment of pulmonary perfusion in humans: the inflow spin-tracer saturation effect. Magn Reson Med 52:1291–1301CrossRefPubMed
26.
Warmuth C, Günther M, Zimmer C (2003) Quantification of blood flow in brain tumors: comparison of arterial spin labeling and dynamic susceptibility-weighted contrast-enhanced MR imaging. Radiology 228:523–532CrossRefPubMed
27.
Warmuth C, Nagel S, Hegemann O, Wlodarczyk W, Lüdemann L (2007) Accuracy of blood flow values determined by arterial spin labeling: a validation study in isolated porcine kidneys. J Magn Reson Imaging 26:353–358CrossRefPubMed
28.
Wang JJ, Heindrich KS, Jackson EK, Ildstad ST, Williams DS, Ho C (1998) Perfusion quantitation in transplanted rat kidney by MRI with arterial spin labeling. Kidney Int 53:1783–1791CrossRefPubMed
Metadata
Title
Quantification of renal allograft perfusion using arterial spin labeling MRI: initial results
Authors
Rotem S. Lanzman
Hans-Jörg Wittsack
Petros Martirosian
Panagiota Zgoura
Philip Bilk
Patric Kröpil
Fritz Schick
Adina Voiculescu
Dirk Blondin
Publication date
01-06-2010
Publisher
Springer-Verlag
Published in
European Radiology / Issue 6/2010
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-009-1675-0

Other articles of this Issue 6/2010

European Radiology 6/2010 Go to the issue

Oncology

RECIST revised: implications for the radiologist. A review article on the modified RECIST guideline

Gastrointestinal

Polyp measurement based on CT colonography and colonoscopy: variability and systematic differences

Interpretation Corner

Primary giant cell tumor of soft tissue: fluid-fluid levels at MRI (2010:3b)

Hepatobiliary-Pancreas

Diagnosis of liver metastases: value of diffusion-weighted MRI compared with gadolinium-enhanced MRI

Chest

Ultralow contrast medium doses at CT to diagnose pulmonary embolism in patients with moderate to severe renal impairment: a feasibility study

Gastrointestinal

Thoracic causes of acute abdominal pain