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European Radiology
Published in: European Radiology 9/2017

01-09-2017 | Contrast Media

Repeated intravenous administration of gadobutrol does not lead to increased signal intensity on unenhanced T1-weighted images—a voxel-based whole brain analysis

Authors: Soenke Langner, Marie-Luise Kromrey, Jens-Peter Kuehn, Matthias Grothe, Martin Domin

Published in: European Radiology | Issue 9/2017

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Abstract

Objectives

To identify a possible association between repeated intravenous administration of gadobutrol and increased signal intensity in the grey and white matter using voxel-based whole-brain analysis.

Methods

In this retrospective single-centre study, 217 patients with a clinically isolated syndrome underwent baseline brain magnetic resonance imaging and at least one annual follow-up examination with intravenous administration of 0.1 mmol/kg body weight of gadobutrol. Using the “Diffeomorphic Anatomical Registration using Exponentiated Lie algebra” (DARTEL) normalisation process, tissue templates for grey matter (GM), white matter (WM), and cerebrospinal fluid (CSF) were calculated, as were GM-CSF and WM-CSF ratios. Voxel-based whole-brain analysis was used to calculate the signal intensity for each voxel in each data set. Paired t-test was applied to test differences to baseline MRI for significance.

Results

Voxel-based whole-brain analysis demonstrated no significant changes in signal intensity of grey and white matter after up to five gadobutrol administrations. There was no significant change in GM-CSF and grey WM-CSF ratios.

Conclusion

Voxel-based whole-brain analysis did not demonstrate increased signal intensity of GM and WM on unenhanced T1-weighted images after repeated gadobutrol administration. The molecular structure of gadolinium-based contrast agent preparations may be an essential factor causing SI increase on unenhanced T1-weighted images.

Key points

• Repeated administration of gadobutrol does not lead to increased signal intensity.
• Voxel-based whole-brain analysis allows assessment of subtle changes in signal intensity.
• Macrocyclic contrast agents in a proven dosage are safe.
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Metadata
Title
Repeated intravenous administration of gadobutrol does not lead to increased signal intensity on unenhanced T1-weighted images—a voxel-based whole brain analysis
Authors
Soenke Langner
Marie-Luise Kromrey
Jens-Peter Kuehn
Matthias Grothe
Martin Domin
Publication date
01-09-2017
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 9/2017
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-017-4777-0

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