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European Radiology

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01-09-2017 | Hepatobiliary-Pancreas

Microwave ablation for the treatment of hepatocellular carcinoma that met up-to-seven criteria: feasibility, local efficacy and long-term outcomes

Authors: Yun Xu, Qiang Shen, Pei Liu, Zhongqi Xu, Panpan Wu, Zhenghua Lu, Yi Chen, Bin Huang, Guojun Qian

Published in: European Radiology | Issue 9/2017

Abstract

Objectives

This study aimed to evaluate the feasibility, local efficacy and long-term outcomes of microwave (MW) ablation for the treatment of hepatocellular carcinoma (HCC) that met up-to-seven criteria.

Methods

Between January 2007 and January 2012, 142 HCC patients with 294 nodules, which conformed to up-to-seven criteria, were enrolled into this retrospective study. All patients were followed up for more than 3 years after receiving MW ablation. Technical success, complications, local tumour progression (LTP) and distant recurrence (DR) were monitored. Recurrence-free survival (RFS), overall survival (OS) and prognostic factors were analysed.

Results

Primary technical efficacy was achieved in 95.2% (280/294) of the carcinomatous nodules, and major complications occurred in four (2.8%) patients. Among the 294 tumours, LTP was observed in 44 (15.0%) tumours. Among the 142 patients, DR was observed in 97 (68.3%) patients. The estimated OS rates after MW ablation at 1, 3 and 5 years were 97.2%, 75.4% and 50.6%, respectively; and the corresponding RFS rates were 76.1%, 33.1% and 19.5%, respectively.

Conclusions

MW ablation is a safe and effective treatment with a high rate of primary technical efficacy for patients with HCC that met up-to-seven criteria.

Key Points

• The first study expanding MW ablation to HCC category beyond Milan criteria.

• The first report that used up-to-seven criteria as indications for MW ablation.

• HCC of up-to-seven criteria viewed as a subgroup of BCLC stage B.

• MW ablation is safe and effective for treating HCC within up-to-seven criteria.

• MW ablation is preferable in treating unresectable HCC within up-to-seven criteria.

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Title: Microwave ablation for the treatment of hepatocellular carcinoma that met up-to-seven criteria: feasibility, local efficacy and long-term outcomes
Authors: Yun Xu
Qiang Shen
Pei Liu
Zhongqi Xu
Panpan Wu
Zhenghua Lu
Yi Chen
Bin Huang
Guojun Qian
Publication date: 01-09-2017
Publisher: Springer Berlin Heidelberg
Published in: European Radiology / Issue 9/2017
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-017-4740-0

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Microwave ablation for the treatment of hepatocellular carcinoma that met up-to-seven criteria: feasibility, local efficacy and long-term outcomes

Abstract

Objectives

Methods

Results

Conclusions

Key Points

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusions

Key Points

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