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European Radiology
Published in: European Radiology 4/2015

01-04-2015 | Interventional

Local tumour progression after ultrasound-guided microwave ablation of liver malignancies: risk factors analysis of 2529 tumours

Authors: Jie Yu, Ping Liang, Xiao-ling Yu, Zhi-gang Cheng, Zhi-yu Han, Meng-juan Mu, Qin-ying Li, Yan-mei Liu

Published in: European Radiology | Issue 4/2015

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Abstract

Objectives

To identify the incidence and risk factors that predict local tumour progression (LTP) after ultrasound-guided percutaneous microwave ablation (MWA) of liver malignancies.

Materials and Methods

One thousand two hundred and nine patients with 2,529 malignant nodules (mean size 2.8 ± 1.4 cm, range 0.9-8.0 cm) were treated by MWA between July 2005 and December 2012. The influence of 11 factors on the risk of LTP was assessed. Univariate Kaplan-Meier and Cox proportional hazard models were used for statistical analysis.

Results

The overall LTP was 4.2 % per tumour and 8.6 % per patient with a median follow-up of 20.3 months. LTP per tumour was 4.3 % for primary liver cancer and 4.1 % for metastases (p = 0.32). The survival of LTP and free-LTP patients at 1, 3, and 5 years was 92.4 %, 71.6 %, and 45.1 %, respectively, and 92.9 %, 70.1 %, and 52.4 %, respectively (p = 0.93). By univariate analysis, tumour location, size and ablation time were significant risk factors of LTP. Multivariate analysis identified tumour size (>3.0 cm) to be the only independent predictor of LTP.

Conclusions

MWA of liver malignancies achieves a relatively low-incidence LTP, although LTP risk significantly increases if tumour size >3.0 cm. The technique seems to be appropriate even for patients with a tumour at a risk location.

Key Points

• Microwave ablation of liver malignancies achieves a low incidence local tumour progression.
• LTP risk significantly increases if the tumour size is >3.0 cm.
• MWA seems to be appropriate even for patients with a tumour at a risk location.
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Metadata
Title
Local tumour progression after ultrasound-guided microwave ablation of liver malignancies: risk factors analysis of 2529 tumours
Authors
Jie Yu
Ping Liang
Xiao-ling Yu
Zhi-gang Cheng
Zhi-yu Han
Meng-juan Mu
Qin-ying Li
Yan-mei Liu
Publication date
01-04-2015
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 4/2015
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-014-3483-4

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