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European Radiology
Published in: European Radiology 9/2017

01-09-2017 | Neuro

Intermediate analysis of magnesium alloy covered stent for a lateral aneurysm model in the rabbit common carotid artery

Authors: Hong-kai Cui, Fen-Bao Li, Ying-Chang Guo, Yong-Li Zhao, Rui-Fang Yan, Wu Wang, Yong-Dong Li, Yong-Li Wang, Guang-Yin Yuan

Published in: European Radiology | Issue 9/2017

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Abstract

Objective

To analyze the outcomes of a magnesium alloy covered stent (MACS) for a lateral aneurysm model in common carotid artery (CCA).

Methods

In 32 rabbits, a MACS (group A, n = 17) or a Willis covered stent (WCS; group B, n = 15) was inserted and the rabbits were sacrificed 1, 3, 6, or 12 months after stenting. Angiography and intravascular ultrasound (IVUS) were performed at 3, 6, and 12 months. Scanning electron microscopy was performed for six stents in each group at 1, 3, and 6 months, and histopathology and histomorphology were conducted at 3 (n = 4), 6 (n = 4), and 12 (n = 12) months.

Results

Final angiography showed complete occlusion of the aneurysms in 12 cases. IVUS at 6 and 12 months revealed a significant increase in mean lumen area of the stented CCA in group A and also showed greater mean lumen area in group A than in group B. The endothelialization process was quicker in group A than in group B.

Conclusion

MACS is effective for occlusion of lateral aneurysms and is superior to WCS in growth of the stented CCA and endothelialization. Further work is needed to make this device available for human use.

Key points

• The MACS is an effective approach for occlusion of a lateral aneurysm.
• IVUS showed that the CCA could grow following degradation of the MACS.
• The lumen area of the stented CCA was excellent in MACS.
• HE staining displayed the degradation of the magnesium alloy stent.
• Combination of IVUS and DSA were applied in this study.
Appendix
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Metadata
Title
Intermediate analysis of magnesium alloy covered stent for a lateral aneurysm model in the rabbit common carotid artery
Authors
Hong-kai Cui
Fen-Bao Li
Ying-Chang Guo
Yong-Li Zhao
Rui-Fang Yan
Wu Wang
Yong-Dong Li
Yong-Li Wang
Guang-Yin Yuan
Publication date
01-09-2017
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 9/2017
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-016-4715-6

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