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European Radiology

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Open Access 01-03-2017 | Computer Applications

CT-based texture analysis potentially provides prognostic information complementary to interim fdg-pet for patients with hodgkin’s and aggressive non-hodgkin’s lymphomas

Authors: B. Ganeshan, K. A. Miles, S. Babikir, R. Shortman, A. Afaq, K. M. Ardeshna, A. M. Groves, I. Kayani

Published in: European Radiology | Issue 3/2017

Abstract

Objectives

The purpose of this study was to investigate the ability of computed tomography texture analysis (CTTA) to provide additional prognostic information in patients with Hodgkin's lymphoma (HL) and high-grade non-Hodgkin's lymphoma (NHL).

Methods

This retrospective, pilot-study approved by the IRB comprised 45 lymphoma patients undergoing routine 18F-FDG-PET-CT. Progression-free survival (PFS) was determined from clinical follow-up (mean-duration: 40 months; range: 10-62 months). Non-contrast-enhanced low-dose CT images were submitted to CTTA comprising image filtration to highlight features of different sizes followed by histogram-analysis using kurtosis. Prognostic value of CTTA was compared to PET FDG-uptake value, tumour-stage, tumour-bulk, lymphoma-type, treatment-regime, and interim FDG-PET (iPET) status using Kaplan-Meier analysis. Cox regression analysis determined the independence of significantly prognostic imaging and clinical features.

Results

A total of 27 patients had aggressive NHL and 18 had HL. Mean PFS was 48.5 months. There was no significant difference in pre-treatment CTTA between the lymphoma sub-types. Kaplan-Meier analysis found pre-treatment CTTA (medium feature scale, p=0.010) and iPET status (p<0.001) to be significant predictors of PFS. Cox analysis revealed that an interaction between pre-treatment CTTA and iPET status was the only independent predictor of PFS (HR: 25.5, 95% CI: 5.4-120, p<0.001). Specifically, pre-treatment CTTA risk stratified patients with negative iPET.

Conclusion

CTTA can potentially provide prognostic information complementary to iPET for patients with HL and aggressive NHL.

Key Points

• CT texture-analysis (CTTA) provides prognostic information complementary to interim FDG-PET in Lymphoma.

• Pre-treatment CTTA and interim PET status were significant predictors of progression-free survival.

• Patients with negative interim PET could be further stratified by pre-treatment CTTA.

• Provide precision surveillance where additional imaging reserved for patients at greatest recurrence-risk.

• Assists in risk-adapted treatment strategy based on interim PET and CTTA.

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Title: CT-based texture analysis potentially provides prognostic information complementary to interim fdg-pet for patients with hodgkin’s and aggressive non-hodgkin’s lymphomas
Authors: B. Ganeshan
K. A. Miles
S. Babikir
R. Shortman
A. Afaq
K. M. Ardeshna
A. M. Groves
I. Kayani
Publication date: 01-03-2017
Publisher: Springer Berlin Heidelberg
Published in: European Radiology / Issue 3/2017
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-016-4470-8

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CT-based texture analysis potentially provides prognostic information complementary to interim fdg-pet for patients with hodgkin’s and aggressive non-hodgkin’s lymphomas

Abstract

Objectives

Methods

Results

Conclusion

Key Points

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusion

Key Points

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