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European Radiology

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01-06-2016 | Oncology

Comparison of contrast-enhanced modified T1-weighted 3D TSE black-blood and 3D MP-RAGE sequences for the detection of cerebral metastases and brain tumours

Authors: N. N. Kammer, E. Coppenrath, K. M. Treitl, H. Kooijman, O. Dietrich, T. Saam

Published in: European Radiology | Issue 6/2016

Abstract

Objectives

To compare a modified T1-weighted 3D TSE black-blood sequence with sub-millimetre resolution (T1-mVISTA) with a magnetization-prepared rapid gradient echo (MP-RAGE) sequence for the diagnosis of cerebral malignomas.

Methods

Forty-six patients with known or suspected intracranial tumours and 15 control patients were included in this retrospective study. All patients underwent T1-mVISTA (0.75-mm isotropic resolution, 4:43 min) and MP-RAGE (0.8-mm isotropic resolution, 4:46 minutes) at 3-Tesla in random order after application of contrast agent. Two experienced radiologists determined the number of lesions. Maximum diameter, diagnostic confidence (DC), visual assessment of contrast enhancement (VCE) and CNR_{lesion/parenchyma} were assessed for each lesion.

Results

Significantly more lesions were detected with T1-mVISTA compared to the MP-RAGE (61 vs. 36; p < 0.05). Further, DC and VCE was rated significantly higher in the T1-mVISTA (p < 0.05 and p < 0.001). Mean CNR_{lesion/parenchyma} was twofold higher for T1-mVISTA (24.2 ± 17.5 vs. 12.7 ± 11.5, p < 0.001). The 25 lesions detected only in T1-mVISTA were significantly smaller than those detected in both sequences (4.3 ± 3.7 mm vs. 11.3 ± 10.7 mm; p < 0.01).

Conclusions

T1-mVISTA increases the contrast of lesions significantly compared to MP-RAGE and might therefore improve detection rates of small lesions in early stages of disease.

Key points

• T1-mVISTA leads to significantly higher contrast-to-noise ratios of cerebral malignomas.

• T1-mVISTA detects significantly more metastatic lesions compared to 3D-MPRAGE.

• Lesions detected only by T1-mVISTA are smaller than those detected in both sequences.

• Diagnostic confidence is significantly higher for lesions detected by T1-mVISTA.

• Application of T1-mVISTA might be of high relevance in early stages of disease.

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Title: Comparison of contrast-enhanced modified T1-weighted 3D TSE black-blood and 3D MP-RAGE sequences for the detection of cerebral metastases and brain tumours
Authors: N. N. Kammer
E. Coppenrath
K. M. Treitl
H. Kooijman
O. Dietrich
T. Saam
Publication date: 01-06-2016
Publisher: Springer Berlin Heidelberg
Published in: European Radiology / Issue 6/2016
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-015-3975-x

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Comparison of contrast-enhanced modified T1-weighted 3D TSE black-blood and 3D MP-RAGE sequences for the detection of cerebral metastases and brain tumours

Abstract

Objectives

Methods

Results

Conclusions

Key points

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusions

Key points

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