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01-04-2011 | Computed Tomography

Commercial software upgrades may significantly alter Perfusion CT parameter values in colorectal cancer

Authors: Vicky Goh, Manu Shastry, Alec Engledow, Jonathan Reston, David M. Wellsted, Jacqui Peck, Raymondo Endozo, Manuel Rodriguez-Justo, Stuart A. Taylor, Steve Halligan, Ashley M Groves

Published in: European Radiology | Issue 4/2011

Abstract

Objective

To determine how commercial software platform upgrades impact on derived parameters for colorectal cancer.

Materials and methods

Following ethical approval, 30 patients with suspected colorectal cancer underwent Perfusion CT using integrated 64 detector PET/CT before surgery. Analysis was performed using software based on modified distributed parameter analysis (Perfusion software version 4; Perfusion 4.0), then repeated using the previous version (Perfusion software version 3; Perfusion 3.0). Tumour blood flow (BF), blood volume (BV), mean transit time (MTT) and permeability surface area product (PS) were determined for identical regions-of-interest. Slice-by-slice and ‘whole tumour’ variance was assessed by Bland-Altman analysis.

Results

Mean BF, BV and PS was 20.4%, 59.5%, and 106% higher, and MTT 14.3% shorter for Perfusion 4.0 than Perfusion 3.0. The mean difference (95% limits of agreement) were +13.5 (−44.9 to 72.0), +2.61 (−0.06 to 5.28), −1.23 (−6.83 to 4.36), and +14.2 (−4.43 to 32.8) for BF, BV, MTT and PS respectively. Within subject coefficient of variation was 36.6%, 38.0%, 27.4% and 60.6% for BF, BV, MTT and PS respectively indicating moderate to poor agreement.

Conclusion

Software version upgrades of the same software platform may result in significantly different parameter values, requiring adjustments for cross-version comparison.

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Title: Commercial software upgrades may significantly alter Perfusion CT parameter values in colorectal cancer
Authors: Vicky Goh
Manu Shastry
Alec Engledow
Jonathan Reston
David M. Wellsted
Jacqui Peck
Raymondo Endozo
Manuel Rodriguez-Justo
Stuart A. Taylor
Steve Halligan
Ashley M Groves
Publication date: 01-04-2011
Publisher: Springer-Verlag
Published in: European Radiology / Issue 4/2011
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-010-1967-4

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Commercial software upgrades may significantly alter Perfusion CT parameter values in colorectal cancer

Abstract

Objective

Materials and methods

Results

Conclusion

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Objective

Materials and methods

Results

Conclusion

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