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01-09-2008 | Cardiac

Quantification of left ventricular function and mass in heart transplant recipients using dual-source CT and MRI: initial clinical experience

Authors: Gorka Bastarrika, Maria Arraiza, Carlo N. De Cecco, Stefano Mastrobuoni, Matias Ubilla, Gregorio Rábago

Published in: European Radiology | Issue 9/2008

Abstract

The purpose of this study was to compare LV function and mass quantification derived from cardiac dual-source CT (DSCT) exams with those obtained by MRI in heart transplant recipients. Twelve heart transplant recipients who underwent cardiac DSCT and MRI examination were included. Double-oblique short-axis 8-mm slice thickness images were evaluated. Left ventricular ejection fraction, end-diastolic volume, end-systolic volume, stroke volume, cardiac output and myocardial mass were manually assessed for each patient by two blinded readers. A systematic overestimation of all left ventricular volumes by DSCT when compared with MRI was observed. Mean difference was 16.58 ± 18.61 ml for EDV, 4.9 4 ± 6.84 ml for ESV, 11.64 ± 13.58 ml for SV and 5.73 ± 1.14 l/min for CO. Slightly lower values for left ventricular ejection fraction with DSCT compared with MRI were observed (mean difference 0.34 ± 3.18%, p = 0.754). Correlation between DSCT and MRI for left ventricular mass was excellent (rho = 0.972). Bland and Altman plots and CCC indicated good agreement between DSCT and MRI left ventricular function and mass measurements. The interobserver correlation was good. In conclusion, DSCT accurately estimates left ventricular ejection fraction, volumes and mass in heart transplant recipients.

Globits S, De Marco T, Schwitter J, Sakuma H, O’Sullivan M, Rifkin C et al (1997) Assessment of early left ventricular remodeling in orthotopic heart transplant recipients with cine magnetic resonance imaging: potential mechanisms. J Heart Lung Transplant 16(5):504–510 MayPubMed

Pennell DJ, Sechtem UP, Higgins CB, Manning WJ, Pohost GM, Rademakers FE et al (2004) Clinical indications for cardiovascular magnetic resonance (CMR): Consensus Panel report. Eur Heart J 25(21):1940–1965 NovPubMedCrossRef

Sandstede J, Lipke C, Beer M, Hofmann S, Pabst T, Kenn W et al (2000) Age-and gender-specific differences in left and right ventricular cardiac function and mass determined by cine magnetic resonance imaging. Eur Radiol 10(3):438–442PubMedCrossRef

Natori S, Lai S, Finn JP, Gomes AS, Hundley WG, Jerosch-Herold M et al (2006) Cardiovascular function in multi-ethnic study of atherosclerosis: normal values by age, sex, and ethnicity. AJR Am J Roentgenol 186(6 Suppl 2):S357–S365 JunPubMedCrossRef

Myerson SG, Bellenger NG, Pennell DJ (2002) Assessment of left ventricular mass by cardiovascular magnetic resonance. Hypertension 39(3):750–755 Mar 1PubMedCrossRef

Leschka S, Alkadhi H, Plass A, Desbiolles L, Grunenfelder J, Marincek B et al (2005) Accuracy of MSCT coronary angiography with 64-slice technology: first experience. Eur Heart J 26(15):1482–1487 AugPubMedCrossRef

Raff GL, Gallagher MJ, O’Neill WW, Goldstein JA (2005) Diagnostic accuracy of noninvasive coronary angiography using 64-slice spiral computed tomography. J Am Coll Cardiol 46(3):552–557 Aug 2PubMedCrossRef

Wintersperger BJ, Nikolaou K, von Ziegler F, Johnson T, Rist C, Leber A et al (2006) Image quality, motion artifacts, and reconstruction timing of 64-slice coronary computed tomography angiography with 0.33-second rotation speed. Invest Radiol 41(5):436–442 MayPubMedCrossRef

Mahnken AH, Koos R, Katoh M, Spuentrup E, Busch P, Wildberger JE et al (2005) Sixteen-slice spiral CT versus MR imaging for the assessment of left ventricular function in acute myocardial infarction. Eur Radiol 15(4):714–720 AprPubMedCrossRef

10.

Cury RC, Nieman K, Shapiro MD, Nasir K, Cury RC, Brady TJ (2007) Comprehensive cardiac CT study: evaluation of coronary arteries, left ventricular function, and myocardial perfusion-is it possible? J Nucl Cardiol 14(2):229–243 AprPubMedCrossRef

11.

Schlosser T, Mohrs OK, Magedanz A, Voigtlander T, Schmermund A, Barkhausen J (2007) Assessment of left ventricular function and mass in patients undergoing computed tomography (CT) coronary angiography using 64-detector-row CT: comparison to magnetic resonance imaging. Acta Radiol 48(1):30–35 FebPubMedCrossRef

12.

Sigurdsson G, Carrascosa P, Yamani MH, Greenberg NL, Perrone S, Lev G et al (2006) Detection of transplant coronary artery disease using multidetector computed tomography with adaptative multisegment reconstruction. J Am Coll Cardiol 48(4):772–778 Aug 15PubMedCrossRef

13.

Romeo G, Houyel L, Angel CY, Brenot P, Riou JY, Paul JF (2005) Coronary stenosis detection by 16-slice computed tomography in heart transplant patients: comparison with conventional angiography and impact on clinical management. J Am Coll Cardiol 45(11):1826–1831 Jun 7PubMedCrossRef

14.

Gregory SA, Ferencik M, Achenbach S, Yeh RW, Hoffmann U, Inglessis I et al (2006) Comparison of sixty-four-slice multidetector computed tomographic coronary angiography to coronary angiography with intravascular ultrasound for the detection of transplant vasculopathy. The American Journal of Cardiology 98(7):877–884 Oct 1PubMedCrossRef

15.

Ferencik M, Gregory SA, Butler J, Achenbach S, Yeh RW, Hoffmann U et al (2007) Analysis of cardiac dimensions, mass and function in heart transplant recipients using 64-slice multi-detector computed tomography. J Heart Lung Transplant 26(5):478–484 MayPubMedCrossRef

16.

Schlosser T, Pagonidis K, Herborn CU, Hunold P, Waltering KU, Lauenstein TC et al (2005) Assessment of left ventricular parameters using 16-MDCT and new software for endocardial and epicardial border delineation. AJR Am J Roentgenol 184(3):765–773 MarPubMed

17.

Flohr TG, McCollough CH, Bruder H, Petersilka M, Gruber K, Suss C et al (2006) First performance evaluation of a dual-source CT (DSCT) system. Eur Radiol 16(2):256–268 FebPubMedCrossRef

18.

Busch S, Johnson TR, Wintersperger BJ, Minaifar N, Bhargava A, Rist C et al (2007) Quantitative assessment of left ventricular function with dual-source CT in comparison to cardiac magnetic resonance imaging: initial findings. Eur Radiol. Oct 2. DOI 10.1007/s00330–007–0767-y

19.

Flohr TG, Stierstorfer K, Ulzheimer S, Bruder H, Primak AN, McCollough CH (2005) Image reconstruction and image quality evaluation for a 64-slice CT scanner with z-flying focal spot. Med Phys 32(8):2536–2547 AugPubMedCrossRef

20.

Mahnken AH, Muhlenbruch G, Koos R, Stanzel S, Busch PS, Niethammer M et al (2006) Automated vs. manual assessment of left ventricular function in cardiac multidetector row computed tomography: comparison with magnetic resonance imaging. Eur Radiol 16(7):1416–1423 JulPubMedCrossRef

21.

Bland JM, Altman DG (1986) Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 1(8476):307–310 Feb 8PubMed

22.

Lin LI (1989) A concordance correlation coefficient to evaluate reproducibility. Biometrics 45(1):255–268 MarPubMedCrossRef

23.

van der Vleuten PA, Willems TP, Gotte MJ, Tio RA, Greuter MJ, Zijlstra F et al (2006) Quantification of global left ventricular function: comparison of multidetector computed tomography and magnetic resonance imaging. a meta-analysis and review of the current literature. Acta Radiol 47(10):1049–1057 DecPubMedCrossRef

24.

Belge B, Coche E, Pasquet A, Vanoverschelde JL, Gerber BL (2006) Accurate estimation of global and regional cardiac function by retrospectively gated multidetector row computed tomography: comparison with cine magnetic resonance imaging. Eur Radiol 16(7):1424–1433. JulPubMedCrossRef

25.

Mahnken AH, Hohl C, Suess C, Bruder H, Muhlenbruch G, Das M et al (2006) Influence of heart rate and temporal resolution on left-ventricular volumes in cardiac multislice spiral computed tomography: a phantom study. Invest Radiol 41(5):429–435 MayPubMedCrossRef

26.

Mahnken AH, Spuentrup E, Niethammer M, Buecker A, Boese J, Wildberger JE et al (2003) Quantitative and qualitative assessment of left ventricular volume with ECG-gated multislice spiral CT: value of different image reconstruction algorithms in comparison to MRI. Acta Radiol 44(6):604–611 NovPubMedCrossRef

27.

Boese JM, Bahner ML, Albers J, van Kaick G (2000) [Optimizing temporal resolution in CT with retrospective ECG gating]. Radiologe 40(2):123–129 FebPubMedCrossRef

28.

Schroeder S, Kopp AF, Kuettner A, Burgstahler C, Herdeg C, Heuschmid M et al (2002) Influence of heart rate on vessel visibility in noninvasive coronary angiography using new multislice computed tomography: experience in 94 patients. Clin Imaging 26(2):106–111 Mar-AprPubMedCrossRef

29.

Schlosser T, Konorza T, Hunold P, Kuhl H, Schmermund A, Barkhausen J (2004) Noninvasive visualization of coronary artery bypass grafts using 16-detector row computed tomography. J Am Coll Cardiol 44(6):1224–1229 Sep 15PubMedCrossRef

30.

Grude M, Juergens KU, Wichter T, Paul M, Fallenberg EM, Muller JG et al (2003) Evaluation of global left ventricular myocardial function with electrocardiogram-gated multidetector computed tomography: comparison with magnetic resonance imaging. Invest Radiol 38(10):653–661 OctPubMedCrossRef

31.

Sugeng L, Mor-Avi V, Weinert L, Niel J, Ebner C, Steringer-Mascherbauer R et al (2006) Quantitative assessment of left ventricular size and function: side-by-side comparison of real-time three-dimensional echocardiography and computed tomography with magnetic resonance reference. Circulation 114(7):654–661 Aug 15PubMedCrossRef

32.

Juergens KU, Grude M, Maintz D, Fallenberg EM, Wichter T, Heindel W et al (2004) Multi-detector row CT of left ventricular function with dedicated analysis software versus MR imaging: initial experience. Radiology 230(2):403–410 FebPubMedCrossRef

33.

Heuschmid M, Rothfuss JK, Schroeder S, Fenchel M, Stauder N, Burgstahler C et al (2006) Assessment of left ventricular myocardial function using 16-slice multidetector-row computed tomography: comparison with magnetic resonance imaging and echocardiography. Eur Radiol 16(3):551–559 MarPubMedCrossRef

34.

Jenkins C, Bricknell K, Hanekom L, Marwick TH (2004) Reproducibility and accuracy of echocardiographic measurements of left ventricular parameters using real-time three-dimensional echocardiography. J Am Coll Cardiol 44(4):878–886 Aug 18PubMedCrossRef

35.

Chuang ML, Hibberd MG, Salton CJ, Beaudin RA, Riley MF, Parker RA et al (2000) Importance of imaging method over imaging modality in noninvasive determination of left ventricular volumes and ejection fraction: assessment by two-and three-dimensional echocardiography and magnetic resonance imaging. J Am Coll Cardiol 35(2):477–484 FebPubMedCrossRef

36.

Bellenger NG, Marcus NJ, Davies C, Yacoub M, Banner NR, Pennell DJ (2000) Left ventricular function and mass after orthotopic heart transplantation: a comparison of cardiovascular magnetic resonance with echocardiography. J Heart Lung Transplant 19(5):444–452 MayPubMedCrossRef

Title: Quantification of left ventricular function and mass in heart transplant recipients using dual-source CT and MRI: initial clinical experience
Authors: Gorka Bastarrika
Maria Arraiza
Carlo N. De Cecco
Stefano Mastrobuoni
Matias Ubilla
Gregorio Rábago
Publication date: 01-09-2008
Publisher: Springer-Verlag
Published in: European Radiology / Issue 9/2008
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-008-0949-2

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Quantification of left ventricular function and mass in heart transplant recipients using dual-source CT and MRI: initial clinical experience

Abstract

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Abstract

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