Skip to main content
Top
Published in: Rheumatology International 3/2019

01-03-2019 | Review

Bulgarian rheumatology: science and practice in a cost-constrained environment

Authors: Tsvetoslav Georgiev, Rumen Stoilov

Published in: Rheumatology International | Issue 3/2019

Login to get access

Abstract

Our aim was to appraise publications from Bulgaria, to assess their global impact, and to describe features and challenges unique to the rheumatology practice in Bulgaria characterized by stringent cost constraints. The Scopus database was queried on 25th July 2018 and data on the number of published documents, their Hirsch-indices and citations number were extracted. Published Bulgarian guidelines for the management of rheumatic diseases and the presented data on Bulgarian Rheumatology Society were identified based on prior knowledge of the authors. From all the identified 1082 document the most extensively researched areas were rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), osteoporosis, and osteoarthritis (OA). For the last five years (from Jan 2013 to 25th July 2018) the number of publications was 293. We found that Bulgaria’s international scientific collaboration in the field of rheumatology is focused on a handful of countries mainly from Europe. Although Bulgarian rheumatologists have access to costly biologic agents for treating their patients with rheumatic diseases, their funding may not be granted according to the current recommendations of European League against Rheumatism (EULAR) and national guidelines for the management of rheumatic diseases. Although the western world clearly dominates the production of scientific publications in rheumatology, Bulgarian rheumatology may present another perspective for diagnosis and management of patients with rheumatic diseases in a cost-stringent environment. Nevertheless, both rheumatology science and practice in Bulgaria still have a long way to go to take its deserved place among the other European countries.
Literature
2.
go back to reference Mikuls TR et al (2013) Rheumatology: a color handbook. CRC Press, Boca Raton Mikuls TR et al (2013) Rheumatology: a color handbook. CRC Press, Boca Raton
4.
go back to reference Orlewska E, Ancuta I, Anic B, Codrenau C, Damjanov N, Djukic P, Ionescu R, Marinchev L, Nasonov EL, Peets T, Praprotnik S (2011) Access to biologic treatment for rheumatoid arthritis in Central and Eastern European (CEE) countries. Med Sci Monit 17(4):SR1CrossRefPubMedPubMedCentral Orlewska E, Ancuta I, Anic B, Codrenau C, Damjanov N, Djukic P, Ionescu R, Marinchev L, Nasonov EL, Peets T, Praprotnik S (2011) Access to biologic treatment for rheumatoid arthritis in Central and Eastern European (CEE) countries. Med Sci Monit 17(4):SR1CrossRefPubMedPubMedCentral
6.
go back to reference Kolarov Z, Monov S (2014) Development of Rheumatology in Bulgaria. In: History of rheumatology in Bulgaria [Развитие на ревматологията в България. В: История на ревматологията в България]. Central Medical Library of Medical University-Sofia, Sofia, pp 13–17 Kolarov Z, Monov S (2014) Development of Rheumatology in Bulgaria. In: History of rheumatology in Bulgaria [Развитие на ревматологията в България. В: История на ревматологията в България]. Central Medical Library of Medical University-Sofia, Sofia, pp 13–17
7.
go back to reference Atanasova E, Pavlova M, Velickovski R, Nikov B, Moutafova E, Groot W (2011) What have 10 years of health insurance reforms brought about in Bulgaria? Re-appraising the Health Insurance Act of 1998. Health Policy 102(2–3):263–269CrossRefPubMed Atanasova E, Pavlova M, Velickovski R, Nikov B, Moutafova E, Groot W (2011) What have 10 years of health insurance reforms brought about in Bulgaria? Re-appraising the Health Insurance Act of 1998. Health Policy 102(2–3):263–269CrossRefPubMed
12.
go back to reference Abubakar II, Tillmann T, Banerjee A (2015) Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet 385(9963):117–171CrossRef Abubakar II, Tillmann T, Banerjee A (2015) Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet 385(9963):117–171CrossRef
13.
go back to reference Emery P (2011) Pocket reference to early rheumatoid arthritis. Springer, BerlinCrossRef Emery P (2011) Pocket reference to early rheumatoid arthritis. Springer, BerlinCrossRef
15.
go back to reference Solakov P, Khristova M (1977) Rheumatoid arthritis among the rural population of southern Bulgaria (transitory morbidity established using the Rome and New York diagnostic criteria). Vutreshni Boles 16(3):52–56 Solakov P, Khristova M (1977) Rheumatoid arthritis among the rural population of southern Bulgaria (transitory morbidity established using the Rome and New York diagnostic criteria). Vutreshni Boles 16(3):52–56
16.
go back to reference Aletaha D et al (2010) 2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis Rheum 62(9):2569–2581CrossRefPubMed Aletaha D et al (2010) 2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis Rheum 62(9):2569–2581CrossRefPubMed
17.
19.
go back to reference Smolen JS, Landewé R, Bijlsma J, Burmester G, Chatzidionysiou K, Dougados M, Nam J, Ramiro S, Voshaar M, van Vollenhoven R, Aletaha D (2017) EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2016 update. Ann Rheum Dis 76(6):960–977CrossRefPubMed Smolen JS, Landewé R, Bijlsma J, Burmester G, Chatzidionysiou K, Dougados M, Nam J, Ramiro S, Voshaar M, van Vollenhoven R, Aletaha D (2017) EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2016 update. Ann Rheum Dis 76(6):960–977CrossRefPubMed
20.
go back to reference Bulgarian Rheumatology Society (2018) National consensus for the treatment of rheumatoid arthritis with biologic agents [Национален консенсус за лечение на ревматоиден артрит с биологични средства] (Internet). http://rheumatologybg.org/download/consensus_3.doc. Accessed 14 Oct 2018 Bulgarian Rheumatology Society (2018) National consensus for the treatment of rheumatoid arthritis with biologic agents [Национален консенсус за лечение на ревматоиден артрит с биологични средства] (Internet). http://​rheumatologybg.​org/​download/​consensus_​3.​doc. Accessed 14 Oct 2018
21.
go back to reference NHIF requirements for the treatment of seropositive rheumatoid and psoriatic arthritis with disease-modifying antirheumatic drugs (DMARDs) in outpatient care [Изисквания на НЗОК при лечение на серопозитивен ревматоиден и псориатичен артрит с болест-модифициращи антиревматични лекарства (БМАРЛ) в извънболничната помощ] (Internet). https://www.nhif.bg/get_file?uuid=79d71f42-0189-4232-af78-97e0f2fd0dbb. Accessed 14 Oct 2018 NHIF requirements for the treatment of seropositive rheumatoid and psoriatic arthritis with disease-modifying antirheumatic drugs (DMARDs) in outpatient care [Изисквания на НЗОК при лечение на серопозитивен ревматоиден и псориатичен артрит с болест-модифициращи антиревматични лекарства (БМАРЛ) в извънболничната помощ] (Internet). https://​www.​nhif.​bg/​get_​file?​uuid=​79d71f42-0189-4232-af78-97e0f2fd0dbb. Accessed 14 Oct 2018
22.
go back to reference NHIF requirements for treatment of moderate to severe active seropositive rheumatoid arthritis, active juvenile arthritis, active and progressive psoriatic arthritis and severe active ankylosing spondylitis with disease-modifying antirheumatic drugs over 18 years of age in outpatient care [Изисквания на НЗОК при лечение на умерен до тежък активен серопозитивен ревматоиден артрит, активен ювенилен артрит, активен и прогресиращ псориатичен артрит и тежък активен анкилозиращ спондилит с антиревматични лекарствени продукти над 18 годишна възраст в извънболничната помощ] (Internet). https://www.nhif.bg/get_file?uuid=74d9c325-9d5c-4494-bc53-68ddc9ccc955. Accessed 14 Oct 2018 NHIF requirements for treatment of moderate to severe active seropositive rheumatoid arthritis, active juvenile arthritis, active and progressive psoriatic arthritis and severe active ankylosing spondylitis with disease-modifying antirheumatic drugs over 18 years of age in outpatient care [Изисквания на НЗОК при лечение на умерен до тежък активен серопозитивен ревматоиден артрит, активен ювенилен артрит, активен и прогресиращ псориатичен артрит и тежък активен анкилозиращ спондилит с антиревматични лекарствени продукти над 18 годишна възраст в извънболничната помощ] (Internet). https://​www.​nhif.​bg/​get_​file?​uuid=​74d9c325-9d5c-4494-bc53-68ddc9ccc955. Accessed 14 Oct 2018
25.
go back to reference van der Heijde D, Ramiro S, Landewé R, Baraliakos X, Van den Bosch F, Sepriano A, Regel A, Ciurea A, Dagfinrud H, Dougados M, van Gaalen F (2017) 2016 update of the ASAS-EULAR management recommendations for axial spondyloarthritis. Annals of the rheumatic diseases. 2016 update of the ASAS-EULAR management recommendations for axial spondyloarthritis. Ann Rheum Dis 76:978–991. https://doi.org/10.1136/annrheumdis-2016-210770 CrossRefPubMed van der Heijde D, Ramiro S, Landewé R, Baraliakos X, Van den Bosch F, Sepriano A, Regel A, Ciurea A, Dagfinrud H, Dougados M, van Gaalen F (2017) 2016 update of the ASAS-EULAR management recommendations for axial spondyloarthritis. Annals of the rheumatic diseases. 2016 update of the ASAS-EULAR management recommendations for axial spondyloarthritis. Ann Rheum Dis 76:978–991. https://​doi.​org/​10.​1136/​annrheumdis-2016-210770 CrossRefPubMed
26.
go back to reference van der Linden S, Valkenburg HA, Cats A (1984) Evaluation of diagnostic criteria for ankylosing spondylitis. Arthritis Rheum 27(4):361–368CrossRefPubMed van der Linden S, Valkenburg HA, Cats A (1984) Evaluation of diagnostic criteria for ankylosing spondylitis. Arthritis Rheum 27(4):361–368CrossRefPubMed
27.
go back to reference Rudwaleit M, Landewé R, Van der Heijde D, Listing J, Brandt J, Braun JV, Burgos-Vargas R, Collantes-Estevez E, Davis J, Dijkmans B, Dougados M (2009) The development of Assessment of SpondyloArthritis International Society classification criteria for axial spondyloarthritis (part I): classification of paper patients by expert opinion including uncertainty appraisal. Ann Rheum Dis 68(6):770–776CrossRefPubMed Rudwaleit M, Landewé R, Van der Heijde D, Listing J, Brandt J, Braun JV, Burgos-Vargas R, Collantes-Estevez E, Davis J, Dijkmans B, Dougados M (2009) The development of Assessment of SpondyloArthritis International Society classification criteria for axial spondyloarthritis (part I): classification of paper patients by expert opinion including uncertainty appraisal. Ann Rheum Dis 68(6):770–776CrossRefPubMed
28.
go back to reference Rudwaleit MV, Van Der Heijde D, Landewé R, Akkoc N, Brandt J, Chou CT, Dougados M, Huang F, Gu J, Kirazli Y, Van den Bosch F (2011) The Assessment of SpondyloArthritis International Society classification criteria for peripheral spondyloarthritis and for spondyloarthritis in general. Ann Rheum Dis 70(1):25–31CrossRefPubMed Rudwaleit MV, Van Der Heijde D, Landewé R, Akkoc N, Brandt J, Chou CT, Dougados M, Huang F, Gu J, Kirazli Y, Van den Bosch F (2011) The Assessment of SpondyloArthritis International Society classification criteria for peripheral spondyloarthritis and for spondyloarthritis in general. Ann Rheum Dis 70(1):25–31CrossRefPubMed
29.
go back to reference Ivanova M, Manolova I, Goycheva P, Stoilov R (2014) Serum cytokines (TNF-alpha and IL-18) in ankylosing spondylitis in relation to disease activity. C R l‘Académie Bulg Sci 67(4):593–606 Ivanova M, Manolova I, Goycheva P, Stoilov R (2014) Serum cytokines (TNF-alpha and IL-18) in ankylosing spondylitis in relation to disease activity. C R l‘Académie Bulg Sci 67(4):593–606
30.
go back to reference Smolen JS, Schöls M, Braun J, Dougados M, FitzGerald O, Gladman DD, Kavanaugh A, Landewé R, Mease P, Sieper J, Stamm T (2018) Treating axial spondyloarthritis and peripheral spondyloarthritis, especially psoriatic arthritis, to target: 2017 update of recommendations by an international task force. Ann Rheum Dis 77(1):3–17CrossRefPubMed Smolen JS, Schöls M, Braun J, Dougados M, FitzGerald O, Gladman DD, Kavanaugh A, Landewé R, Mease P, Sieper J, Stamm T (2018) Treating axial spondyloarthritis and peripheral spondyloarthritis, especially psoriatic arthritis, to target: 2017 update of recommendations by an international task force. Ann Rheum Dis 77(1):3–17CrossRefPubMed
34.
go back to reference McAlindon TE, Cooper C, Kirwan JR, Dieppe PA (1992) Knee pain and disability in the community. Br J Rheumatol 31:189–192CrossRefPubMed McAlindon TE, Cooper C, Kirwan JR, Dieppe PA (1992) Knee pain and disability in the community. Br J Rheumatol 31:189–192CrossRefPubMed
35.
go back to reference Nuesch E, Dieppe P, Reichenbach S et al (2011) All cause and disease specific mortality in patients with knee or hip osteoarthritis: population based cohort study. BMJ 342:d1165CrossRefPubMedPubMedCentral Nuesch E, Dieppe P, Reichenbach S et al (2011) All cause and disease specific mortality in patients with knee or hip osteoarthritis: population based cohort study. BMJ 342:d1165CrossRefPubMedPubMedCentral
36.
go back to reference Felson DT, Lawrence RC, Dieppe PA et al (2000) Osteoarthritis: new insights. Part 1: the disease and its risk factors. Ann Intern Med 133(8):635–646CrossRefPubMed Felson DT, Lawrence RC, Dieppe PA et al (2000) Osteoarthritis: new insights. Part 1: the disease and its risk factors. Ann Intern Med 133(8):635–646CrossRefPubMed
38.
go back to reference Georgiev T, Stoilov R, Penkov M, Ivanova M, Trifonov A (2016) Radiographic assessment of knee osteoarthritis. Revmatologiia (Bulgaria) 24(2):16–24 Georgiev T, Stoilov R, Penkov M, Ivanova M, Trifonov A (2016) Radiographic assessment of knee osteoarthritis. Revmatologiia (Bulgaria) 24(2):16–24
40.
go back to reference Kraus VB, Burnett B, Coindreau J et al (2011) Application of biomarkers in the development of drugs intended for the treatment of osteoarthritis. Osteoarthritis Cartil 19(5):515–542CrossRef Kraus VB, Burnett B, Coindreau J et al (2011) Application of biomarkers in the development of drugs intended for the treatment of osteoarthritis. Osteoarthritis Cartil 19(5):515–542CrossRef
41.
go back to reference Georgiev T, Ivanova M, Kopchev A, Velikova T, Miloshov A, Kurteva E, Yuzeir K, Penkov M, Kabakchieva P, Rashkov R, Stoilov R (2018) Cartilage oligomeric protein, matrix metalloproteinase-3, and Coll2-1 as serum biomarkers in knee osteoarthritis: a cross-sectional study. Rheumatol Int 38(5):821–830CrossRefPubMed Georgiev T, Ivanova M, Kopchev A, Velikova T, Miloshov A, Kurteva E, Yuzeir K, Penkov M, Kabakchieva P, Rashkov R, Stoilov R (2018) Cartilage oligomeric protein, matrix metalloproteinase-3, and Coll2-1 as serum biomarkers in knee osteoarthritis: a cross-sectional study. Rheumatol Int 38(5):821–830CrossRefPubMed
42.
go back to reference Simon TM, Jackson DW (2018) Articular cartilage: injury pathways and treatment options. Sports Med Arthrosc Rev 26(1):31–39CrossRefPubMed Simon TM, Jackson DW (2018) Articular cartilage: injury pathways and treatment options. Sports Med Arthrosc Rev 26(1):31–39CrossRefPubMed
45.
go back to reference Miteva LD, Manolova IM, Ivanova MG, Rashkov RK, Stoilov RM, Gulubova MV, Stanilova SA (2012) Functional genetic polymorphisms in interleukin-12B gene in association with systemic lupus erythematosus. Rheumatol Int 32(1):53–59CrossRefPubMed Miteva LD, Manolova IM, Ivanova MG, Rashkov RK, Stoilov RM, Gulubova MV, Stanilova SA (2012) Functional genetic polymorphisms in interleukin-12B gene in association with systemic lupus erythematosus. Rheumatol Int 32(1):53–59CrossRefPubMed
47.
go back to reference Tedeschi SK, Johnson SR, Boumpas D, Daikh D, Dörner T, Jayne D, Kamen D, Lerstrøm K, Mosca M, Ramsey-Goldman R, Sinnette C (2018) Developing and refining new candidate criteria for systemic lupus erythematosus classification: an international collaboration. Arthritis Care Res 70(4):571–581. https://doi.org/10.1002/acr.23317 CrossRef Tedeschi SK, Johnson SR, Boumpas D, Daikh D, Dörner T, Jayne D, Kamen D, Lerstrøm K, Mosca M, Ramsey-Goldman R, Sinnette C (2018) Developing and refining new candidate criteria for systemic lupus erythematosus classification: an international collaboration. Arthritis Care Res 70(4):571–581. https://​doi.​org/​10.​1002/​acr.​23317 CrossRef
48.
go back to reference Hochberg MC (1997) Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 40(9):1725–1725CrossRefPubMed Hochberg MC (1997) Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 40(9):1725–1725CrossRefPubMed
49.
go back to reference Fonseca AR, Gaspar-Elsas MI, Land MG, de Oliveira SK (2015) Comparison between three systems of classification criteria in juvenile systemic lupus erythematous. Rheumatology 54:241–247CrossRefPubMed Fonseca AR, Gaspar-Elsas MI, Land MG, de Oliveira SK (2015) Comparison between three systems of classification criteria in juvenile systemic lupus erythematous. Rheumatology 54:241–247CrossRefPubMed
54.
go back to reference Merrill JT, Neuwelt CM, Wallace DJ, Shanahan JC, Latinis KM, Oates JC, Utset TO, Gordon C, Isenberg DA, Hsieh HJ, Zhang D (2010) Efficacy and safety of rituximab in moderately-to-severely active systemic lupus erythematosus: The randomized, double-blind, phase II/III systemic lupus erythematosus evaluation of rituximab trial. Arthritis Rheum 62:222–233. https://doi.org/10.1002/art.27233 CrossRefPubMedPubMedCentral Merrill JT, Neuwelt CM, Wallace DJ, Shanahan JC, Latinis KM, Oates JC, Utset TO, Gordon C, Isenberg DA, Hsieh HJ, Zhang D (2010) Efficacy and safety of rituximab in moderately-to-severely active systemic lupus erythematosus: The randomized, double-blind, phase II/III systemic lupus erythematosus evaluation of rituximab trial. Arthritis Rheum 62:222–233. https://​doi.​org/​10.​1002/​art.​27233 CrossRefPubMedPubMedCentral
55.
go back to reference Clowse ME, Wallace DJ, Furie RA, Petri MA, Pike MC, Leszczyński P, Neuwelt CM, Hobbs K, Keiserman M, Duca L, Kalunian KC et al (2017) Efficacy and safety of epratuzumab in moderately to severely active systemic lupus erythematosus: results from two phase III randomized, double-blind, placebo-controlled trials. Arthritis Rheumatol 69(2):362–375CrossRefPubMedPubMedCentral Clowse ME, Wallace DJ, Furie RA, Petri MA, Pike MC, Leszczyński P, Neuwelt CM, Hobbs K, Keiserman M, Duca L, Kalunian KC et al (2017) Efficacy and safety of epratuzumab in moderately to severely active systemic lupus erythematosus: results from two phase III randomized, double-blind, placebo-controlled trials. Arthritis Rheumatol 69(2):362–375CrossRefPubMedPubMedCentral
56.
go back to reference Mavragani CP, Nezos A, Moutsopoulos HM (2013) New advances in the classification, pathogenesis and treatment of Sjogren’s syndrome. Curr Opin Rheumatol 25(5):623–629CrossRefPubMed Mavragani CP, Nezos A, Moutsopoulos HM (2013) New advances in the classification, pathogenesis and treatment of Sjogren’s syndrome. Curr Opin Rheumatol 25(5):623–629CrossRefPubMed
57.
58.
go back to reference Vivino FB, Carsons SE, Foulks G, Daniels TE, Parke A, Brennan MT, Forstot SL, Scofield RH, Hammitt KM (2016) New treatment guidelines for Sjögren’s disease. Rheum Dis Clin 42(3):531–551CrossRef Vivino FB, Carsons SE, Foulks G, Daniels TE, Parke A, Brennan MT, Forstot SL, Scofield RH, Hammitt KM (2016) New treatment guidelines for Sjögren’s disease. Rheum Dis Clin 42(3):531–551CrossRef
59.
go back to reference Bolster MB, Silver RM (2015) Clinical features of systemic sclerosis. In: Hochberg MC, Silman AJ, Smolen JS et al (eds) Rheumatology, 6th edn. Mosby, St. Louis, pp 1165–1176 Bolster MB, Silver RM (2015) Clinical features of systemic sclerosis. In: Hochberg MC, Silman AJ, Smolen JS et al (eds) Rheumatology, 6th edn. Mosby, St. Louis, pp 1165–1176
60.
go back to reference Wei J, Bhattacharyya S, Tourtellotte WG et al (2011) Fibrosis in systemic sclerosis: emerging concepts and implications for targeted therapy. Autoimmun Rev 10(5):267–275CrossRefPubMed Wei J, Bhattacharyya S, Tourtellotte WG et al (2011) Fibrosis in systemic sclerosis: emerging concepts and implications for targeted therapy. Autoimmun Rev 10(5):267–275CrossRefPubMed
61.
62.
go back to reference Chifflot H, Fautrel B, Sordet C, Chatelus E, Sibilia J. Incidence and prevalence of systemic sclerosis: a systematic literature review. In: Seminars in arthritis and rheumatism, 1 Feb 2008 (vol 37, No. 4, pp. 223–235). WB Saunders, Philadelphia Chifflot H, Fautrel B, Sordet C, Chatelus E, Sibilia J. Incidence and prevalence of systemic sclerosis: a systematic literature review. In: Seminars in arthritis and rheumatism, 1 Feb 2008 (vol 37, No. 4, pp. 223–235). WB Saunders, Philadelphia
63.
go back to reference Van Den Hoogen F, Khanna D, Fransen J, Johnson SR, Baron M, Tyndall A, Matucci-Cerinic M, Naden RP, Medsger TA Jr, Carreira PE, Riemekasten G (2013) 2013 classification criteria for systemic sclerosis: an American College of Rheumatology/European League against Rheumatism collaborative initiative. Arthritis Rheum 65(11):2737–2747CrossRefPubMedPubMedCentral Van Den Hoogen F, Khanna D, Fransen J, Johnson SR, Baron M, Tyndall A, Matucci-Cerinic M, Naden RP, Medsger TA Jr, Carreira PE, Riemekasten G (2013) 2013 classification criteria for systemic sclerosis: an American College of Rheumatology/European League against Rheumatism collaborative initiative. Arthritis Rheum 65(11):2737–2747CrossRefPubMedPubMedCentral
64.
go back to reference Krasimirova E, Velikova T, Tumangelova-Yuzeir K, Ivanova-Todorova E, Kyurkchiev D, Kalinova D, Reshkova V, Kopchev A, Rashkov R (2016) A wide immunological profile in the diagnosis of progressive systemic sclerosis. Revmatologiia (Bulgaria) 24(2):35–51 Krasimirova E, Velikova T, Tumangelova-Yuzeir K, Ivanova-Todorova E, Kyurkchiev D, Kalinova D, Reshkova V, Kopchev A, Rashkov R (2016) A wide immunological profile in the diagnosis of progressive systemic sclerosis. Revmatologiia (Bulgaria) 24(2):35–51
66.
go back to reference Kowal-Bielecka O, Fransen J, Avouac J et al (2017) Update of EULAR recommendations for the treatment of systemic sclerosis. Ann Rheum Dis 76:1327–1339CrossRefPubMed Kowal-Bielecka O, Fransen J, Avouac J et al (2017) Update of EULAR recommendations for the treatment of systemic sclerosis. Ann Rheum Dis 76:1327–1339CrossRefPubMed
69.
go back to reference Kalinova D, Kopchev A, Nikolaeva S, Rashkov R (2016) Autoimmune myositis—histological features in the skin and muscle biopsies. Revmatologiia (Bulgaria) 24(4):28–34 Kalinova D, Kopchev A, Nikolaeva S, Rashkov R (2016) Autoimmune myositis—histological features in the skin and muscle biopsies. Revmatologiia (Bulgaria) 24(4):28–34
71.
go back to reference Jennette J, Falk R, Bacon P, Basu N, Cid MC, Ferrario F et al (2013) 2012 revised International Chapel Hill consensus conference nomenclature of vasculitides. Arthritis Rheum 65:1–11CrossRefPubMed Jennette J, Falk R, Bacon P, Basu N, Cid MC, Ferrario F et al (2013) 2012 revised International Chapel Hill consensus conference nomenclature of vasculitides. Arthritis Rheum 65:1–11CrossRefPubMed
72.
go back to reference Arend WP, Michel BA, Bloch DA, Hunder GG, Calabrese LH, Edworthy SM et al (1990) The American College of Rheumatology 1990 criteria for the classification of Takayasu arteritis. Arthritis Rheum 33:1129–1134CrossRefPubMed Arend WP, Michel BA, Bloch DA, Hunder GG, Calabrese LH, Edworthy SM et al (1990) The American College of Rheumatology 1990 criteria for the classification of Takayasu arteritis. Arthritis Rheum 33:1129–1134CrossRefPubMed
73.
go back to reference Hunder GG, Bloch DA, Michel BA, Stevens MB, Arend WP, Calabrese LH et al (1990) The American College of Rheumatology 1990 criteria for the classification of giant cell arteritis. Arthritis Rheum 33:1122–1128CrossRefPubMed Hunder GG, Bloch DA, Michel BA, Stevens MB, Arend WP, Calabrese LH et al (1990) The American College of Rheumatology 1990 criteria for the classification of giant cell arteritis. Arthritis Rheum 33:1122–1128CrossRefPubMed
74.
go back to reference Dourmishev AL, Serafimova DK, Vassileva SG, Dourmishev LA, Schwartz RA (2005) Segmental ulcerative vasculitis: a cutaneous manifestation of Takayasu’s arteritis. Int Wound J 2(4):340–345CrossRefPubMedPubMedCentral Dourmishev AL, Serafimova DK, Vassileva SG, Dourmishev LA, Schwartz RA (2005) Segmental ulcerative vasculitis: a cutaneous manifestation of Takayasu’s arteritis. Int Wound J 2(4):340–345CrossRefPubMedPubMedCentral
75.
go back to reference Petrov IS et al (2018) Late outcomes after interventional treatment—successful stenting of Takayasu arteritis lesions. Single center experience in Bulgaria. Cor Vasa 60(2):e114–e121CrossRef Petrov IS et al (2018) Late outcomes after interventional treatment—successful stenting of Takayasu arteritis lesions. Single center experience in Bulgaria. Cor Vasa 60(2):e114–e121CrossRef
80.
go back to reference Yoneva T, Rashkov R, Zdravkova Y (2015) Clinical and immunological analysis of the patients with ANCA associated vasculitides in the rheumatology clinic. Revmatologiia (Bulgaria) 23(4):31–47 Yoneva T, Rashkov R, Zdravkova Y (2015) Clinical and immunological analysis of the patients with ANCA associated vasculitides in the rheumatology clinic. Revmatologiia (Bulgaria) 23(4):31–47
Metadata
Title
Bulgarian rheumatology: science and practice in a cost-constrained environment
Authors
Tsvetoslav Georgiev
Rumen Stoilov
Publication date
01-03-2019
Publisher
Springer Berlin Heidelberg
Published in
Rheumatology International / Issue 3/2019
Print ISSN: 0172-8172
Electronic ISSN: 1437-160X
DOI
https://doi.org/10.1007/s00296-018-4202-2

Other articles of this Issue 3/2019

Rheumatology International 3/2019 Go to the issue