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01-05-2015 | Original Article - Epidemiology of RMD

Effects of cigarette smoking on early arthritis: a cross-sectional study—data from the Argentine Consortium for Early Arthritis (CONAART)

Authors: María Jezabel Haye Salinas, Soledad Retamozo, Ana Cecilia Alvarez, Hernán Maldonado Ficco, Fernando Dal Pra, Gustavo Citera, Mariana Benegas, Rafael Chaparro del Moral, Oscar Rillo, Anastasia Secco, Lucila Marino Claverie, Antonio Catalan Pellet, Josefina Marcos, Mercedes Argentina García, Juan Carlos Marcos, Ana Barbaglia, Verónica Bellomio, Alberto Berman, Cristian Quiroz, Enrique R Soriano, Federico Ceccato, Sergio Paira, Doralia Vazquez, Vicente Ricardo Juarez, Edson Javier Velozo, Gabriela Salvatierra, Francisco Caeiro

Published in: Rheumatology International | Issue 5/2015

Abstract

Our objective was to analyze the effects of cigarette smoking on disease activity, functional capacity, radiographic damage, serology and presence of extraarticular manifestations in patients with rheumatoid arthritis and undifferentiated arthritis. This is a cross-sectional study of 1,305 patients (729 with rheumatoid arthritis and 576 with undifferentiated arthritis) from CONAART, the Argentine Consortium for Early Arthritis that includes patients older than 16 years with <2 years of disease. Sociodemographic data, clinical characteristics of the disease and smoking history were collected. In patients with rheumatoid arthritis the disease activity score of 28 joints was 5.4 ± 1.3 in current smokers, 5.2 ± 1.4 in former smokers and 5.1 ± 1.4 in never smokers (p = 0.011). The simple erosion narrowing score was higher in current smokers and former smokers than in never smokers (M 14.0, R _Q 6.0–21.0; M 15.0, R _Q 7.0–24.0; M 10.0, R _Q 5.0–17.0; p = 0.006). Current smokers had higher rheumatoid factor titer (M 160.0, R _Q 80.0–341.0) than former smokers (M 146.8, R _Q 6.03–255.5) and never smokers (M 15.0, R _Q 9.0–80.0) (p = 0.004). The variable independently associated with tobacco exposure was simple erosion narrowing score (OR = 1.03, 95 % CI 1.00–1.05; p = 0.012). In patients with undifferentiated arthritis, an association between smoking status and parameters of activity or radiographic damage was not observed. Neither was tobacco exposure related to the presence of extraarticular manifestations or to the degree of disability in any of the two groups of patients. No relation was found between disease activity and severity, and number of packs smoked per year. Tobacco.

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Title: Effects of cigarette smoking on early arthritis: a cross-sectional study—data from the Argentine Consortium for Early Arthritis (CONAART)
Authors: María Jezabel Haye Salinas
Soledad Retamozo
Ana Cecilia Alvarez
Hernán Maldonado Ficco
Fernando Dal Pra
Gustavo Citera
Mariana Benegas
Rafael Chaparro del Moral
Oscar Rillo
Anastasia Secco
Lucila Marino Claverie
Antonio Catalan Pellet
Josefina Marcos
Mercedes Argentina García
Juan Carlos Marcos
Ana Barbaglia
Verónica Bellomio
Alberto Berman
Cristian Quiroz
Enrique R Soriano
Federico Ceccato
Sergio Paira
Doralia Vazquez
Vicente Ricardo Juarez
Edson Javier Velozo
Gabriela Salvatierra
Francisco Caeiro
Publication date: 01-05-2015
Publisher: Springer Berlin Heidelberg
Published in: Rheumatology International / Issue 5/2015
Print ISSN: 0172-8172
Electronic ISSN: 1437-160X
DOI: https://doi.org/10.1007/s00296-014-3188-7

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