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Rheumatology International
Published in: Rheumatology International 5/2015

01-05-2015 | Letter to the Editor - Critique and Appraisal

The lack of efficacy of oxytocin and NSAIDs

Authors: Roberta Agabio, Sergio Mameli, Maria Rosaria Melis

Published in: Rheumatology International | Issue 5/2015

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Excerpt

We read with interest the Commentary of Drs. Kwong and Chan on the lack of analgesic effects induced by the administration of oxytocin nasal spray to fibromyalgic patients [1‐3]. We agree with them that these negative results are very disappointing, particularly as the inverse relationship between plasma oxytocin levels and the severity of pain found by other studies persuaded us to conduct our study [4]. …
Literature
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Kwong KK, Chan S (2014) Intranasal oxytocin and NSAIDs. Comment on: oxytocin nasal spray in fibromyalgic patients. Rheumatol Int [Epub ahead of print]
2.
Mameli S, Pisanu G, Sardo S, Marchi A, Pili A, Carboni M, Minerba L, Trincas G, Carta MG, Melis MR, Agabio R (2014) Oxytocin nasal spray in fibromyalgic patients. Rheumatol Int 34:1047–1052CrossRefPubMed
3.
Agabio R, Mameli S, Sardo S, Minerba L, Melis MR (2014) Oxytocin nasal spray in fibromyalgic patients: additional information: reply to the comment to the editor entitled “Future directions for the investigation of intranasal oxytocin and pain”. Rheumatol Int 34:1335–1336CrossRefPubMed
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Anderberg UM, Uvnäs-Moberg K (2000) Plasma oxytocin levels in female fibromyalgia syndrome patients. Z Rheumatol 59:373–379CrossRefPubMed
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Pamuk ON, Cakir N (2005) The variation in chronic widespread pain and other symptoms in fibromyalgia patients. The effects of menses and menopause. Clin Exp Rheumatol 23:778–782PubMed
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Salonia A, Nappi RE, Pontillo M, Daverio R, Smeraldi A, Briganti A, Fabbri F, Zanni G, Rigatti P, Montorsi F (2005) Menstrual cycle-related changes in plasma oxytocin are relevant to normal sexual function in healthy women. Horm Behav 47:164–169CrossRefPubMed
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Yeomans DC, Angst M, Mechanic J, Jacobs D (2013) Therapeutic effect of nasal oxytocin in chronic migraine: dependence on cytokines. In: International Headache Congress 2013, Boston: Cephalalgia 33:58–59
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Ohlsson B, Truedsson M, Bengtsson M, Torstenson R, Sjölund K, Björnsson ES, Simren M (2005) Effects of long-term treatment with oxytocin in chronic constipation; a double blind, placebo-controlled pilot trial. Neurogastroenterol Motil 17:697–704CrossRefPubMed
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Wang YL, Yuan Y, Yang J, Wang CH, Pan YJ, Lu L, Wu YQ, Wang DX, Lv LX, Li RR, Xue L, Wang XH, Bi JW, Liu XF, Qian YN, Deng ZK, Zhang ZJ, Zhai XH, Zhou XJ, Wang GL, Zhai JX, Liu WY (2013) The interaction between the oxytocin and pain modulation in headache patients. Neuropeptides 47:93–97CrossRefPubMed
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Robinson ICAF (1985) Radioimmunoassay of oxytocin: the standard. In: oxytocin: clinical and laboratory studies. In: Amico JA, Robinson AG (eds) Excerpta Medica International Congress Series 666, 2nd edn. Elsevier Science Publishers, Amsterdam, pp 24–30
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Knigge U, Kjaer A, Kristoffersen U, Madsen K, Toftegaard C, Jørgensen H, Warberg J (2003) Histamine and prostaglandin interaction in regulation of oxytocin and vasopressin secretion. J Neuroendocrinol 15:940–945CrossRefPubMed
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Pulkkinen MO (1979) Suppression of uterine activity by prostaglandin synthetase inhibitors. Acta Obstet Gynecol Scand Supp 87:39–43CrossRef
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Caldwell JD, Hruby VJ, Hill P, Prange AJ Jr, Pedersen CA (1986) Is oxytocin induced grooming mediated by uterine-like receptors? Neuropeptides 8:77–86CrossRefPubMed
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Caldwell JD, Walker CH, O’Rourke ST, Faggin BM, Morris M, Mason GA (1996) Analogies between oxytocin systems of the uterus and brain. Horm Metab Res 28:65–74CrossRefPubMed
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Argiolas A, Melis MR, Stancampiano R, Gessa GL (1990) Oxytocin-induced penile erection and yawning: role of calcium and prostaglandins. Pharmacol Biochem Behav 35:601–605CrossRefPubMed
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Rash JA, Campbell TS (2014) Future directions for the investigation of intranasal oxytocin and pain: comment on: Oxytocin nasal spray in fibromyalgic patients. Rheumatol Int 34:1177–1178CrossRefPubMed
Metadata
Title
The lack of efficacy of oxytocin and NSAIDs
Authors
Roberta Agabio
Sergio Mameli
Maria Rosaria Melis
Publication date
01-05-2015
Publisher
Springer Berlin Heidelberg
Published in
Rheumatology International / Issue 5/2015
Print ISSN: 0172-8172
Electronic ISSN: 1437-160X
DOI
https://doi.org/10.1007/s00296-014-3200-2

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Keynote webinar | Spotlight on medication adherence

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WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

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