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Published in: Rheumatology International 11/2014

01-11-2014 | Original Article

Effectiveness of extracorporeal shock wave therapy in bone marrow edema syndrome of the hip

Authors: Cristina d’Agostino, Pietro Romeo, Vito Lavanga, Salvatore Pisani, Valerio Sansone

Published in: Rheumatology International | Issue 11/2014

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Abstract

There is no gold standard for treatment of bone marrow edema syndrome of the hip (BMESH). Usually, treatment is conservative, owing to the favorable and self-limiting prognosis. In musculoskeletal disorders, the effectiveness of extracorporeal shock wave therapy (ESWT) has been widely recognized and recent research supports its use in the treatment of the first stages of avascular osteonecrosis of the proximal femur and in other conditions where bone marrow edema is present. On this basis, we performed a prospective study to evaluate the effectiveness of ESWT in normalizing the symptoms and imaging features of BMESH. Twenty consecutive symptomatic patients underwent two treatments of high-energy ESWT and were followed-up at 2, 3 and 6 months, with a final clinical follow-up at mean 15.52 ± 1.91 months. Patients underwent magnetic resonance imaging of the hip and were evaluated according to the Harris hip score. The mean improvement in HHS over the course of the study was of 58.5 ± 14.9 points (p < 0.0001), and the mean edema area reduced from 981.9 ± 453.2 mm2 pre-treatment to 107.8 ± 248.1 mm2 at 6 months. ESWT seems to be a powerful, non-pharmacological tool that produces rapid pain relief and functional improvement and aids the normalization of the vascular and metabolic impairments which characterize BMESH.
Literature
1.
go back to reference Blum A, Roch D, Loeuille D, Lousi M, Bath T, Lecoeq S, Witte Y (2009) L’oedema meddullaire: definition, valeur diagnostique et pronostique. J Radiol 90:1789–1811PubMedCrossRef Blum A, Roch D, Loeuille D, Lousi M, Bath T, Lecoeq S, Witte Y (2009) L’oedema meddullaire: definition, valeur diagnostique et pronostique. J Radiol 90:1789–1811PubMedCrossRef
2.
go back to reference Koo KH, Ahn IO, Kim R et al (1999) Bone marrow edema and associated pain in early stage osteonecrosis of the femoral head: prospective study with serial MR images. Radiology 213(3):715–722PubMedCrossRef Koo KH, Ahn IO, Kim R et al (1999) Bone marrow edema and associated pain in early stage osteonecrosis of the femoral head: prospective study with serial MR images. Radiology 213(3):715–722PubMedCrossRef
3.
go back to reference Koo KH, Ahn IO, Song HR, Kim SY, Jones JP Jr (2002) Increased perfusion of the femoral head in transient bone marrow edema syndrome. Clin Orthop Relat Res 402:171–175PubMedCrossRef Koo KH, Ahn IO, Song HR, Kim SY, Jones JP Jr (2002) Increased perfusion of the femoral head in transient bone marrow edema syndrome. Clin Orthop Relat Res 402:171–175PubMedCrossRef
4.
go back to reference Hofmann S (2005) The painful bone marrow edema syndrome of the hip joint. Wien Klin Wochenschr 117(4):111–120PubMedCrossRef Hofmann S (2005) The painful bone marrow edema syndrome of the hip joint. Wien Klin Wochenschr 117(4):111–120PubMedCrossRef
5.
go back to reference Vande Berg BC, Lecouvert FE, Koutaissoff S, Simoni P, Malghem J (2008) Bone marrow edema of the femoral head and transient osteoporosis of the hip. Eur J Radiol 67:68–77PubMedCrossRef Vande Berg BC, Lecouvert FE, Koutaissoff S, Simoni P, Malghem J (2008) Bone marrow edema of the femoral head and transient osteoporosis of the hip. Eur J Radiol 67:68–77PubMedCrossRef
6.
go back to reference Curtiss PH, Kincaid WE (1959) Transitory demineralization of the hip in pregnancy. J Bone Jt Surg Am 41-A:1327–1333 Curtiss PH, Kincaid WE (1959) Transitory demineralization of the hip in pregnancy. J Bone Jt Surg Am 41-A:1327–1333
7.
go back to reference Plenk H Jr, Hofmann S, Eschberger J et al (1997) Histomorphology and bone morphometry of the bone marrow edema syndrome of the hip. Clin Orthop Relat Res 334:73–84PubMedCrossRef Plenk H Jr, Hofmann S, Eschberger J et al (1997) Histomorphology and bone morphometry of the bone marrow edema syndrome of the hip. Clin Orthop Relat Res 334:73–84PubMedCrossRef
8.
go back to reference Guardiano SA, Katz J, Schwartz AM, Brindle K, Curiel R (2004) Fracture complicating the bone marrow edema syndrome. J Clin Rheumatol 10:269–274PubMedCrossRef Guardiano SA, Katz J, Schwartz AM, Brindle K, Curiel R (2004) Fracture complicating the bone marrow edema syndrome. J Clin Rheumatol 10:269–274PubMedCrossRef
9.
go back to reference Guerra JJ, Steinberg ME (1995) Distinguishing transient osteoporosis from avascular necrosis of the hip. J Bone Jt Surg Am 77:616–624 Guerra JJ, Steinberg ME (1995) Distinguishing transient osteoporosis from avascular necrosis of the hip. J Bone Jt Surg Am 77:616–624
10.
go back to reference Hayes CW, Balkissoon AA (1996) Magnetic resonance imaging of the musculoskeletal system. II. The hip. Clin Orthop 322:297–309PubMedCrossRef Hayes CW, Balkissoon AA (1996) Magnetic resonance imaging of the musculoskeletal system. II. The hip. Clin Orthop 322:297–309PubMedCrossRef
11.
go back to reference Radke S, Kenn W, Eulert J (2004) Transient bone marrow edema syndrome progressing to the avascular necrosis of the hip—a case report and a review of the literature. Clin Rheumatol 23:83–88PubMedCrossRef Radke S, Kenn W, Eulert J (2004) Transient bone marrow edema syndrome progressing to the avascular necrosis of the hip—a case report and a review of the literature. Clin Rheumatol 23:83–88PubMedCrossRef
12.
go back to reference Radke S, Rader C, Kenn W, Kirschner S, Walther M, Eulert J (2003) Transient marrow edema syndrome of the hip: results after core decompression. A prospective MRI-controlled study in 22 patients. Arch Orthop Trauma Surg 123:223–227PubMed Radke S, Rader C, Kenn W, Kirschner S, Walther M, Eulert J (2003) Transient marrow edema syndrome of the hip: results after core decompression. A prospective MRI-controlled study in 22 patients. Arch Orthop Trauma Surg 123:223–227PubMed
13.
go back to reference Aigner N, Petje G, Schneider W et al (2005) Bone marrow edema syndrome of the femoral head: treatment with the prostacyclin analogue iloprost vs core decompression. An MRI-controlled study. Wien Klin Wochenschr 117(4):130–135PubMedCrossRef Aigner N, Petje G, Schneider W et al (2005) Bone marrow edema syndrome of the femoral head: treatment with the prostacyclin analogue iloprost vs core decompression. An MRI-controlled study. Wien Klin Wochenschr 117(4):130–135PubMedCrossRef
14.
go back to reference Ogden JA, Tóth-Kischkat A, Schultheiss R (2001) Principles of shock wave therapy. Clin Orthop Relat Res 387:8–17PubMedCrossRef Ogden JA, Tóth-Kischkat A, Schultheiss R (2001) Principles of shock wave therapy. Clin Orthop Relat Res 387:8–17PubMedCrossRef
15.
go back to reference Wang FS, Yang KD, Kuo YR et al (2003) Temporal and spatial expression of bone morphogenetic proteins in extracorporeal shock wave-promoted healing of segmental defect. Bone 32:387–396PubMedCrossRef Wang FS, Yang KD, Kuo YR et al (2003) Temporal and spatial expression of bone morphogenetic proteins in extracorporeal shock wave-promoted healing of segmental defect. Bone 32:387–396PubMedCrossRef
16.
go back to reference Wang CJ, Yang YJ, Huang CC (2011) The effects of shockwave on systemic concentrations of nitric oxide level, angiogenesis and osteogenesis factors in hip necrosis. Rheumatol Int 31(7):871–877PubMedCrossRef Wang CJ, Yang YJ, Huang CC (2011) The effects of shockwave on systemic concentrations of nitric oxide level, angiogenesis and osteogenesis factors in hip necrosis. Rheumatol Int 31(7):871–877PubMedCrossRef
17.
go back to reference Mariotto S, Carcereri de Prati A, Cavalieri E et al (2009) Extracorporeal shock wave therapy in inflammatory diseases: molecular mechanism that trigger anti-inflammatory action. Curr Med Chem 16:2366–2372PubMedCrossRef Mariotto S, Carcereri de Prati A, Cavalieri E et al (2009) Extracorporeal shock wave therapy in inflammatory diseases: molecular mechanism that trigger anti-inflammatory action. Curr Med Chem 16:2366–2372PubMedCrossRef
18.
go back to reference Romeo P, d’Agostino MC, Lazzerini A, Sansone VC (2011) Extracorporeal shock wave therapy in pillar pain after carpal tunnel release: a preliminary study. Ultrasound Med Biol 37(10):1603–1608PubMedCrossRef Romeo P, d’Agostino MC, Lazzerini A, Sansone VC (2011) Extracorporeal shock wave therapy in pillar pain after carpal tunnel release: a preliminary study. Ultrasound Med Biol 37(10):1603–1608PubMedCrossRef
19.
go back to reference Wang CJ, Wang FS, Huang CC, Yang KD, Weng LH, Huang HY (2005) Treatment for osteonecrosis of the femoral head: comparison of extracorporeal shock waves with core decompression and bone-grafting. J Bone Jt Surg Am 87(11):2380–2387CrossRef Wang CJ, Wang FS, Huang CC, Yang KD, Weng LH, Huang HY (2005) Treatment for osteonecrosis of the femoral head: comparison of extracorporeal shock waves with core decompression and bone-grafting. J Bone Jt Surg Am 87(11):2380–2387CrossRef
20.
go back to reference Wang CJ, Wang FS, Ko JY et al (2008) Extracorporeal shockwave therapy shows regeneration in hip necrosis. Rheumatology 47(4):542–546PubMedCrossRef Wang CJ, Wang FS, Ko JY et al (2008) Extracorporeal shockwave therapy shows regeneration in hip necrosis. Rheumatology 47(4):542–546PubMedCrossRef
21.
go back to reference Vulpiani MC, Vetrano M, Trischitta D et al (2012) Extracorporeal shock wave therapy in early osteonecrosis of the femoral head: prospective clinical study with long-term follow-up. Arch Orthop Trauma Surg 132(4):499–508PubMedCrossRef Vulpiani MC, Vetrano M, Trischitta D et al (2012) Extracorporeal shock wave therapy in early osteonecrosis of the femoral head: prospective clinical study with long-term follow-up. Arch Orthop Trauma Surg 132(4):499–508PubMedCrossRef
22.
go back to reference Tamma R, Dell’Endice S, Notarnicola A et al (2009) Extracorporeal shock waves stimulate osteoblastic activities. Ultrasound Med Biol 35(12):2093–2100PubMedCrossRef Tamma R, Dell’Endice S, Notarnicola A et al (2009) Extracorporeal shock waves stimulate osteoblastic activities. Ultrasound Med Biol 35(12):2093–2100PubMedCrossRef
23.
go back to reference Van Der Jagt OP, Van Der Linden JC, Shaden W et al (2009) Unfocused extracorporeal shock wave therapy as potential treatment for osteoporosis. J Orthop Res 27(11):1528–1533PubMedCrossRef Van Der Jagt OP, Van Der Linden JC, Shaden W et al (2009) Unfocused extracorporeal shock wave therapy as potential treatment for osteoporosis. J Orthop Res 27(11):1528–1533PubMedCrossRef
24.
go back to reference Gardeniers JWM (1992) A new international classification of osteonecrosis of the ARCO Committee on terminology and classification. J Jpn Orthop Assoc 66:18–20 Gardeniers JWM (1992) A new international classification of osteonecrosis of the ARCO Committee on terminology and classification. J Jpn Orthop Assoc 66:18–20
25.
go back to reference Ahlback S (1968) Osteoarthrosis of the knee. A radiographic investigation. Acta Radiol Diagn (Stockh) Suppl 277:7–72 Ahlback S (1968) Osteoarthrosis of the knee. A radiographic investigation. Acta Radiol Diagn (Stockh) Suppl 277:7–72
26.
go back to reference Ludwig J, Lauber S, Lauber HJ, Dreisilker U, Raedel R, Hotzinger H (2001) High-energy shock wave treatment of femoral head necrosis in adults. Clin Orthop Relat Res 387:119–126PubMedCrossRef Ludwig J, Lauber S, Lauber HJ, Dreisilker U, Raedel R, Hotzinger H (2001) High-energy shock wave treatment of femoral head necrosis in adults. Clin Orthop Relat Res 387:119–126PubMedCrossRef
27.
go back to reference Lin PC, Wang CJ, Yang KD, Wang FS, Ko JY, Huang CC (2006) Extracorporeal shockwave treatment of osteonecrosis of the femoral head in systemic lupus erythematosis. J Arthroplast 21(6):911–915CrossRef Lin PC, Wang CJ, Yang KD, Wang FS, Ko JY, Huang CC (2006) Extracorporeal shockwave treatment of osteonecrosis of the femoral head in systemic lupus erythematosis. J Arthroplast 21(6):911–915CrossRef
28.
go back to reference Gotte G, Amelio E, Russo S et al (2002) Short time non-enzymatic nitric oxide synthesis from L-arginine and hydrogen peroxide induced by shock waves treatment. FEBS Lett 520(1–3):153–155PubMedCrossRef Gotte G, Amelio E, Russo S et al (2002) Short time non-enzymatic nitric oxide synthesis from L-arginine and hydrogen peroxide induced by shock waves treatment. FEBS Lett 520(1–3):153–155PubMedCrossRef
30.
go back to reference Brandi ML, Hukkanen M, Umeda T et al (1995) Bidirectional regulation of osteoclasts function by nitric oxide synthase isoforms. Proc Natl Acad Sci USA 92(7):2954–2958PubMedCrossRefPubMedCentral Brandi ML, Hukkanen M, Umeda T et al (1995) Bidirectional regulation of osteoclasts function by nitric oxide synthase isoforms. Proc Natl Acad Sci USA 92(7):2954–2958PubMedCrossRefPubMedCentral
31.
go back to reference Hukkanen M, Platts LA, Lawes T et al (2003) Effect of nitric oxide donor nitroglycerin on bone mineral density in a rat model of estrogen deficiency-induced osteopenia. Bone 32(2):142–149PubMedCrossRef Hukkanen M, Platts LA, Lawes T et al (2003) Effect of nitric oxide donor nitroglycerin on bone mineral density in a rat model of estrogen deficiency-induced osteopenia. Bone 32(2):142–149PubMedCrossRef
32.
go back to reference Martini L, Giavaresi G, Fini M et al (2003) Effect of extracorporeal shock wave therapy on osteoblastlike cells. Clin Orthop Rel Res 413:269–280CrossRef Martini L, Giavaresi G, Fini M et al (2003) Effect of extracorporeal shock wave therapy on osteoblastlike cells. Clin Orthop Rel Res 413:269–280CrossRef
33.
go back to reference Tam KF, Cheung Wing H, Lee K, Qin L, Leung KS (2005) Delayed stimulatory effect of low-intensity shockwaves on human periosteal cells. Clin Orthop Relat Res 438:260–265PubMedCrossRef Tam KF, Cheung Wing H, Lee K, Qin L, Leung KS (2005) Delayed stimulatory effect of low-intensity shockwaves on human periosteal cells. Clin Orthop Relat Res 438:260–265PubMedCrossRef
34.
go back to reference Wang CJ, Yang KD, Ko JY, Huang CC, Huang HY, Wang FS (2009) The effects of shockwave on bone healing and systemic concentrations of nitric oxide (NO), TGF-beta1, VEGF and BMP-2 in long bone non-unions. Nitric Oxide 20(4):298–303PubMedCrossRef Wang CJ, Yang KD, Ko JY, Huang CC, Huang HY, Wang FS (2009) The effects of shockwave on bone healing and systemic concentrations of nitric oxide (NO), TGF-beta1, VEGF and BMP-2 in long bone non-unions. Nitric Oxide 20(4):298–303PubMedCrossRef
35.
go back to reference D’Agostino C, Romeo P, Amelio E, Sansone V (2011) Effectiveness of ESWT in the treatment of Kienböck’s disease. Ultrasound Med Biol 37(9):1452–1456PubMedCrossRef D’Agostino C, Romeo P, Amelio E, Sansone V (2011) Effectiveness of ESWT in the treatment of Kienböck’s disease. Ultrasound Med Biol 37(9):1452–1456PubMedCrossRef
36.
go back to reference Szkopek K, Warming T, Neergaard K, Jørgensen HL, Christensen HE, Krogsgaard M (2012) Pain and knee function in relation to degree of bone bruise after acute anterior cruciate ligament rupture. Scand J Med Sci Sports 22(5):635–642PubMedCrossRef Szkopek K, Warming T, Neergaard K, Jørgensen HL, Christensen HE, Krogsgaard M (2012) Pain and knee function in relation to degree of bone bruise after acute anterior cruciate ligament rupture. Scand J Med Sci Sports 22(5):635–642PubMedCrossRef
37.
go back to reference Boks SS, Vroegindeweij D, Koes BW, Hunink MG, Bierma-Zienstra SM (2006) Follow-up of occult bone lesions detected at MR imaging: systematic review. Radiology 238:853–862PubMedCrossRef Boks SS, Vroegindeweij D, Koes BW, Hunink MG, Bierma-Zienstra SM (2006) Follow-up of occult bone lesions detected at MR imaging: systematic review. Radiology 238:853–862PubMedCrossRef
38.
go back to reference Disch AC, Matziolis G, Perka C (2005) The management of necrosis-associated and idiopathic bone-marrow oedema of the proximal femur by intravenous iloprost. J Bone Jt Surg Br 87(4):560–564CrossRef Disch AC, Matziolis G, Perka C (2005) The management of necrosis-associated and idiopathic bone-marrow oedema of the proximal femur by intravenous iloprost. J Bone Jt Surg Br 87(4):560–564CrossRef
39.
go back to reference Jager M, Tillman FP, Thornill TS et al (2008) Rationale for prostaglandin I2 in bone marrow edema—from theory to application. Arthritis Res Ther 10(5):R120PubMedCrossRefPubMedCentral Jager M, Tillman FP, Thornill TS et al (2008) Rationale for prostaglandin I2 in bone marrow edema—from theory to application. Arthritis Res Ther 10(5):R120PubMedCrossRefPubMedCentral
40.
go back to reference Meizer R, Meraner D, Meizer E, Radda C, Landsiedl F, Aigner N (2009) Outcome of painful bone marrow edema of the femoral head following treatment with parenteral iloprost Indian. J Orthop 43(1):36–39 Meizer R, Meraner D, Meizer E, Radda C, Landsiedl F, Aigner N (2009) Outcome of painful bone marrow edema of the femoral head following treatment with parenteral iloprost Indian. J Orthop 43(1):36–39
41.
go back to reference Varenna M, Zucchi F, Binelli L, Failoni S, Gallazzi M, Sinigaglia L (2002) Intravenous pamidronate in the treatment of transient osteoporosis of the hip. Bone 31(1):96–101PubMedCrossRef Varenna M, Zucchi F, Binelli L, Failoni S, Gallazzi M, Sinigaglia L (2002) Intravenous pamidronate in the treatment of transient osteoporosis of the hip. Bone 31(1):96–101PubMedCrossRef
42.
go back to reference Emad Y, Ragab Y, El-Shaarawy N, Rasker JJ (2012) Transient osteoporosis of the hip, complete resolution after treatment with alendronate as observed by MRI description of eight cases and review of the literature. Clin Rheumatol 31:1641–1647PubMedCrossRef Emad Y, Ragab Y, El-Shaarawy N, Rasker JJ (2012) Transient osteoporosis of the hip, complete resolution after treatment with alendronate as observed by MRI description of eight cases and review of the literature. Clin Rheumatol 31:1641–1647PubMedCrossRef
43.
go back to reference Fabbriciani G, Pirro M, Manfredelli MR et al (2012) Transient osteoporosis of the hip: successful treatment with teriparatide. Rheumatol Int 32:1367–1370PubMedCrossRef Fabbriciani G, Pirro M, Manfredelli MR et al (2012) Transient osteoporosis of the hip: successful treatment with teriparatide. Rheumatol Int 32:1367–1370PubMedCrossRef
44.
go back to reference Hofmann S, Engel A, Neuhold A, Leder K, Kramer J, Plenk H Jr (1993) Bone-marrow oedema syndrome and transient osteoporosis of the hip. An MRI-controlled study of treatment by core decompression. J Bone Jt Surg Br 75(2):210–216 Hofmann S, Engel A, Neuhold A, Leder K, Kramer J, Plenk H Jr (1993) Bone-marrow oedema syndrome and transient osteoporosis of the hip. An MRI-controlled study of treatment by core decompression. J Bone Jt Surg Br 75(2):210–216
45.
46.
go back to reference Assaf AT, Smeets R, Riecke B, Weise E, Gröbe A, Blessmann M, Steiner T, Wikner J, Friedrich RE, Heiland M, Hoelzle F, Gerhards F (2013) Incidence of bisphosphonate-related osteonecrosis of the jaw in consideration of primary diseases and concomitant therapies. Anticancer Res 33(9):3917–3924PubMed Assaf AT, Smeets R, Riecke B, Weise E, Gröbe A, Blessmann M, Steiner T, Wikner J, Friedrich RE, Heiland M, Hoelzle F, Gerhards F (2013) Incidence of bisphosphonate-related osteonecrosis of the jaw in consideration of primary diseases and concomitant therapies. Anticancer Res 33(9):3917–3924PubMed
Metadata
Title
Effectiveness of extracorporeal shock wave therapy in bone marrow edema syndrome of the hip
Authors
Cristina d’Agostino
Pietro Romeo
Vito Lavanga
Salvatore Pisani
Valerio Sansone
Publication date
01-11-2014
Publisher
Springer Berlin Heidelberg
Published in
Rheumatology International / Issue 11/2014
Print ISSN: 0172-8172
Electronic ISSN: 1437-160X
DOI
https://doi.org/10.1007/s00296-014-2991-5

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