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Rheumatology International
Published in: Rheumatology International 8/2006

01-06-2006 | Case Report

SLE-associated transverse myelitis successfully treated with Rituximab (anti-CD20 monoclonal antibody)

Authors: D. J. Armstrong, M. T. McCarron, G. D. Wright

Published in: Rheumatology International | Issue 8/2006

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Excerpt

Rituximab (anti-CD20 monoclonal antibody) has been used successfully in the treatment of systemic lupus erythematosus (SLE) [1, 2], but SLE-associated neurological impairment has not figured prominently in previous reports with Rituximab. We describe an SLE patient with transverse myelitis in whom treatment with cyclophosphamide had been difficult and ultimately unsuccessful, who responded dramatically to two infusions of Rituximab. …
Literature
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Weide H, Pandorf K (2003) Successful long term treatment of SLE with Rituximab maintainance therapy. Lupus 12(10):779–782CrossRef
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Kovacs B, Lafferty TL, Brent LH, DeHoratius RJ (2000) Transverse myelopathy in systemic lupus erythematosus: an analysis of 14 cases and review of the literature. Ann Rheum Dis 59(2):120–124PubMedCrossRef
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D’Cruz DP, Mellor-Pita S, Joven B, Sanna G, Allanson J, Taylor J, Khamashta MA, Hughes GR (2004) Transverse myelitis as the first manifestation of systemic lupus erythematosus or lupus-like disease: good functional outcome and relevance of anti-phospholipid antibodies. J Rheumatol 31(2):280–285PubMed
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Tellez-Zenteno JF, Remes-Troche JM, Negrete-Pulido RO, Davila-Maldonao L (2001) Longitudinal myelitis associated with systemic lupus erythematosus: clinical features and magnetic resonance imaging of six cases. Lupus 10(12):851–856PubMedCrossRef
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Kimura KY, Seino Y, Hirayama Y, Aramaki T, Yamaguchi H, Amano H, Takano T (2002) Systemic lupus erythematosus related transverse myelitis presenting with longitudinal involvement of the spinal cord. Intern Med 41(2):156–160PubMedCrossRef
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Perrotta S, Locatelli F, La Manna A, Cennamo L, De Stefano P, Nobili B (2002) Anti-CD20 monoclonal antibody (Rituximab) for life-threatening autoimmune haemolytic anaemia in a patient with systemic lupus erythematosus. Br J Haematol 116(2):465–467PubMed
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Looney RJ, Anolik JH, Campbell D, Felgar RE, Young F, Arend LJ, Sloand JA, Rosenblatt J, Sanz I (2004) B cell depletion as a novel treatment for systemic lupus erythematosus: a phase I/II dose-escalation trial of rituximab. Arthritis Rheum 50(8):2580–2589PubMedCrossRef
Metadata
Title
SLE-associated transverse myelitis successfully treated with Rituximab (anti-CD20 monoclonal antibody)
Authors
D. J. Armstrong
M. T. McCarron
G. D. Wright
Publication date
01-06-2006
Publisher
Springer-Verlag
Published in
Rheumatology International / Issue 8/2006
Print ISSN: 0172-8172
Electronic ISSN: 1437-160X
DOI
https://doi.org/10.1007/s00296-005-0068-1

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