Skip to main content
Top
Published in: Rheumatology International 2/2004

01-03-2004 | Original Article

Is female predominance in irritable bowel syndrome related to fibromyalgia?

Authors: Selami Akkuş, Altug Senol, Naime Bayram Ayvacioglu, Ercan Tunc, Ibrahim Eren, Mehmet Isler

Published in: Rheumatology International | Issue 2/2004

Login to get access

Abstract

Irritable bowel syndrome (IBS) and fibromyalgia (FM) are common functional diseases in adult women. The aim of this study was to investigate whether female predominance in IBS is related to FM. Fifty patients with IBS and 50 healthy controls were enrolled. All participants answered questionnaires including personal and medical history. In addition, psychiatric interviews were conducted. Patients were divided into two groups according to the coexistence of FM ( IBS+FM or IBS only). The data obtained from patients with or without FM and the control group were compared. There was a significant female predominance in patients with IBS+FM (83.4%, F:M=5:1), but IBS-only patients consisted mainly of males (59.4%, F:M=2:3) (P<0.01). Comparison of IBS+FM and IBS-only patients showed no significant difference in depression and anxiety status. However, both anxiety and depression scores were found to be higher in female IBS patients than their male counterparts (P<0.01 and P<0.05, respectively). Our findings suggest that the female predominance in IBS patients may result from coexisting FM.
Literature
1.
go back to reference American Gastroenterological Association Patient Care Committee (1997) Irritable bowel syndrome: a technical review for practice guideline development. Gastroenterology 112:2120–2137PubMed American Gastroenterological Association Patient Care Committee (1997) Irritable bowel syndrome: a technical review for practice guideline development. Gastroenterology 112:2120–2137PubMed
2.
go back to reference Taub E, Cuevas JL, Cook EW, Crowell M, Whitehead WE (1995) Irritable bowel syndrome defined by factor analysis: gender and race comparisons. Dig Dis Sci 5:1761–1769 Taub E, Cuevas JL, Cook EW, Crowell M, Whitehead WE (1995) Irritable bowel syndrome defined by factor analysis: gender and race comparisons. Dig Dis Sci 5:1761–1769
3.
go back to reference Jones R, Lydeard S (1992) Irritable bowel syndrome in the general population. BMJ 304:87–90PubMed Jones R, Lydeard S (1992) Irritable bowel syndrome in the general population. BMJ 304:87–90PubMed
4.
go back to reference Drossman DA, Li Z, Andruzzi E, Temple RD, Talley NJ, Thompson WG (1993) U.S. householder survey of functional GI disorders, prevalence, sociodemography and health impact. Dig Dis Sci 38:1569–1580PubMed Drossman DA, Li Z, Andruzzi E, Temple RD, Talley NJ, Thompson WG (1993) U.S. householder survey of functional GI disorders, prevalence, sociodemography and health impact. Dig Dis Sci 38:1569–1580PubMed
5.
go back to reference Wolfe F, Smythe HA, Yunus MB, Bennett RM, Bombardier C, Goldenberg DL et al (1990) The American College of Rheumatology 1990 criteria for the classification of fibromyalgia: report of the multicenter criteria committee. Arthritis Rheum 33:160–172PubMed Wolfe F, Smythe HA, Yunus MB, Bennett RM, Bombardier C, Goldenberg DL et al (1990) The American College of Rheumatology 1990 criteria for the classification of fibromyalgia: report of the multicenter criteria committee. Arthritis Rheum 33:160–172PubMed
6.
go back to reference Goldenberg DL (1998) Fibromyalgia and related syndromes. In: Klippel JH, Dieppe PA (eds) Rheumatology. Mosby, Philadelphia, pp 1–12 Goldenberg DL (1998) Fibromyalgia and related syndromes. In: Klippel JH, Dieppe PA (eds) Rheumatology. Mosby, Philadelphia, pp 1–12
7.
go back to reference Campbell SM, Clark S, Tindall EA, Forehand ME, Bennett RM (1983) Clinical characteristics of fibrositis. Arthritis Rheum 26:817–824PubMed Campbell SM, Clark S, Tindall EA, Forehand ME, Bennett RM (1983) Clinical characteristics of fibrositis. Arthritis Rheum 26:817–824PubMed
8.
go back to reference Yunus M, Masi AT, Calabro JJ, Miller K, Feigenbaum SL (1981) Primary fibromyalgia (fibrositis): clinical study of 50 patients with matched normal controls. Semin Arthritis Rheum 11:151–171PubMed Yunus M, Masi AT, Calabro JJ, Miller K, Feigenbaum SL (1981) Primary fibromyalgia (fibrositis): clinical study of 50 patients with matched normal controls. Semin Arthritis Rheum 11:151–171PubMed
9.
go back to reference Veale D, Kavanagh G, Fielding JF, Fıtzgerald O (1991) Primary fibromyalgia and the irritable bowel syndrome: different expressions of a common pathogenetic process. Br J Rheumatol 30:220–222PubMed Veale D, Kavanagh G, Fielding JF, Fıtzgerald O (1991) Primary fibromyalgia and the irritable bowel syndrome: different expressions of a common pathogenetic process. Br J Rheumatol 30:220–222PubMed
10.
go back to reference Sivri A, Cindaş A, Dinçer F, Sivri B (1996) Bowel dysfunction and irritable bowel syndrome in fibromyalgia patients. Clin Rheumatol 15:283–286PubMed Sivri A, Cindaş A, Dinçer F, Sivri B (1996) Bowel dysfunction and irritable bowel syndrome in fibromyalgia patients. Clin Rheumatol 15:283–286PubMed
11.
go back to reference Triadafilopoulos G, Simms RW, Goldenberg DL (1991) Bowel dysfunction in fibromyalgia syndrome. Dis Dig Sci 36:59–64 Triadafilopoulos G, Simms RW, Goldenberg DL (1991) Bowel dysfunction in fibromyalgia syndrome. Dis Dig Sci 36:59–64
12.
go back to reference Hudson JL, Goldenberg DL, Pope HG, Keck PE, Schlesinger L (1991) Comorbidity of fibromyalgia with medical and psychiatric disorders. Am J Med 92:363–367 Hudson JL, Goldenberg DL, Pope HG, Keck PE, Schlesinger L (1991) Comorbidity of fibromyalgia with medical and psychiatric disorders. Am J Med 92:363–367
13.
go back to reference Barton A, Pal B, Whorwell PJ, Marshall D (1999) Increased prevalence of sicca complex and fibromyalgia in patients with irritable bowel syndrome. Am J Gastroenterol 94:1898–1901CrossRef Barton A, Pal B, Whorwell PJ, Marshall D (1999) Increased prevalence of sicca complex and fibromyalgia in patients with irritable bowel syndrome. Am J Gastroenterol 94:1898–1901CrossRef
14.
go back to reference Sperber AD, Atzmon Y, Neumann L, Weisberg I, Shailt Y, Abu-Shakrah M (1999) Fibromyalgia in the irritable bowel syndrome: studies of prevalence and clinical implications. Am J Gastroenterol 94:3541–3546CrossRefPubMed Sperber AD, Atzmon Y, Neumann L, Weisberg I, Shailt Y, Abu-Shakrah M (1999) Fibromyalgia in the irritable bowel syndrome: studies of prevalence and clinical implications. Am J Gastroenterol 94:3541–3546CrossRefPubMed
15.
go back to reference Lubrano E, Iovino P, Tremolaterra F, Parsons WJ, Ciacci C, Mazzacca G (2001) Fibromyalgia in patients with irritable bowel syndrome. An association with the severity of the intestinal disorder. Int J Colorectal Dis 16:211–215 Lubrano E, Iovino P, Tremolaterra F, Parsons WJ, Ciacci C, Mazzacca G (2001) Fibromyalgia in patients with irritable bowel syndrome. An association with the severity of the intestinal disorder. Int J Colorectal Dis 16:211–215
16.
go back to reference Drossman DA, Thompson GW, Talley NJ, Funche-Jensen P, Whitehead WE (1990) Identification of subgroups of functional gastrointestinal disorders. Gastroenterol Int 3:159–172 Drossman DA, Thompson GW, Talley NJ, Funche-Jensen P, Whitehead WE (1990) Identification of subgroups of functional gastrointestinal disorders. Gastroenterol Int 3:159–172
17.
go back to reference Hamilton M (1960) A rating scale for depression. J Neurol Neurosurg Psychiatry 23:56–62 Hamilton M (1960) A rating scale for depression. J Neurol Neurosurg Psychiatry 23:56–62
18.
go back to reference Hamilton M (1959) Assessment of anxiety states by rating. Br J Med Psychol 32:50–55 Hamilton M (1959) Assessment of anxiety states by rating. Br J Med Psychol 32:50–55
19.
go back to reference American Psychiatric Association (1994) Diagnostic and statistical manual of mental disorders. Fourth edn. (DSM-IV). American Psychiatric Press, Washington DC American Psychiatric Association (1994) Diagnostic and statistical manual of mental disorders. Fourth edn. (DSM-IV). American Psychiatric Press, Washington DC
20.
go back to reference Kay L, Jorgensen T, Jensen KH (1994) The epidemiology of irritable bowel syndrome in random population: prevalence, incidence, natural history and risk factors. J Intern Med 236:23–30PubMed Kay L, Jorgensen T, Jensen KH (1994) The epidemiology of irritable bowel syndrome in random population: prevalence, incidence, natural history and risk factors. J Intern Med 236:23–30PubMed
21.
go back to reference Toner BB, Akman D (2000) Gender role and irritable bowel syndrome: literature review and hypothesis. Am J Gastroenterol 95:11–16CrossRefPubMed Toner BB, Akman D (2000) Gender role and irritable bowel syndrome: literature review and hypothesis. Am J Gastroenterol 95:11–16CrossRefPubMed
24.
go back to reference Lee OY, Mayer EA, Schmulson M, Chang L, Naliboff B (2001) Gender-related differences in IBS symptoms. Am J Gastroenterol 96:2184–2193CrossRefPubMed Lee OY, Mayer EA, Schmulson M, Chang L, Naliboff B (2001) Gender-related differences in IBS symptoms. Am J Gastroenterol 96:2184–2193CrossRefPubMed
25.
go back to reference Talley N, Fett S, Zinsmeister A (1995) Self-reported abuse and gastrointestinal disease in outpatients: association with irritable bowel-type symptoms. Am J Gastroenterol 90:366–371PubMed Talley N, Fett S, Zinsmeister A (1995) Self-reported abuse and gastrointestinal disease in outpatients: association with irritable bowel-type symptoms. Am J Gastroenterol 90:366–371PubMed
26.
go back to reference Drosman DA, Leserman J, Nachman G, Li Z, Gluck H, Toomey TC (1990) Sexual and physical abuse in women with functional or organic gastrointestinal disorders. Ann Intern Med 113:828–833PubMed Drosman DA, Leserman J, Nachman G, Li Z, Gluck H, Toomey TC (1990) Sexual and physical abuse in women with functional or organic gastrointestinal disorders. Ann Intern Med 113:828–833PubMed
27.
go back to reference Whitehead WE, Bosmajian L, Zonderman AB, Costa PT, Schuster MM (1988) Symptoms of psychological distress associated with irritable bowel syndrome. Gastroenterol 95:709–714 Whitehead WE, Bosmajian L, Zonderman AB, Costa PT, Schuster MM (1988) Symptoms of psychological distress associated with irritable bowel syndrome. Gastroenterol 95:709–714
28.
go back to reference MacFarlane TV, Blinkhorn AB, Worthington HV, Davies RM, MacFarlane GJ (2002) Sex hormonal factors and chronic widespread pain: a population study among women. Rheumatology 41:454–457CrossRefPubMed MacFarlane TV, Blinkhorn AB, Worthington HV, Davies RM, MacFarlane GJ (2002) Sex hormonal factors and chronic widespread pain: a population study among women. Rheumatology 41:454–457CrossRefPubMed
29.
go back to reference Whorwell PJ, McCallum M, Creed FH, Roberts CT (1986) Non-colonic features of irritable bowel syndrome. Gut 27:37–40PubMed Whorwell PJ, McCallum M, Creed FH, Roberts CT (1986) Non-colonic features of irritable bowel syndrome. Gut 27:37–40PubMed
30.
go back to reference Levy RL, Whitehead WE, Korff MR, Feld AD (2000) Intergenerational transmission of gastrointestinal illness behavior. Am J Gastroenterol 95:451–456CrossRefPubMed Levy RL, Whitehead WE, Korff MR, Feld AD (2000) Intergenerational transmission of gastrointestinal illness behavior. Am J Gastroenterol 95:451–456CrossRefPubMed
31.
go back to reference Blanchard EB, Keefer L, Galowski TE, Taylor AE, Turner SM (2001) Gender differences in psychological distress among patients with irritable bowel syndrome. J Psychosom Res 50:271–275CrossRefPubMed Blanchard EB, Keefer L, Galowski TE, Taylor AE, Turner SM (2001) Gender differences in psychological distress among patients with irritable bowel syndrome. J Psychosom Res 50:271–275CrossRefPubMed
Metadata
Title
Is female predominance in irritable bowel syndrome related to fibromyalgia?
Authors
Selami Akkuş
Altug Senol
Naime Bayram Ayvacioglu
Ercan Tunc
Ibrahim Eren
Mehmet Isler
Publication date
01-03-2004
Publisher
Springer-Verlag
Published in
Rheumatology International / Issue 2/2004
Print ISSN: 0172-8172
Electronic ISSN: 1437-160X
DOI
https://doi.org/10.1007/s00296-003-0328-x

Other articles of this Issue 2/2004

Rheumatology International 2/2004 Go to the issue