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Open Access 01-04-2020 | Herpes Virus | Review

Epigenetic control in Kaposi sarcoma-associated herpesvirus infection and associated disease

Authors: Jacqueline Fröhlich, Adam Grundhoff

Published in: Seminars in Immunopathology | Issue 2/2020

Abstract

Kaposi sarcoma-associated herpesvirus (KSHV) is the etiologic agent of several malignancies of endothelial and B-cell origin. The fact that latently infected tumor cells in these malignancies do not express classical viral oncogenes suggests that pathogenesis of KSHV-associated disease results from multistep processes that, in addition to constitutive viral gene expression, may require accumulation of cellular alterations. Heritable changes of the epigenome have emerged as an important co-factor that contributes to the pathogenesis of many non-viral cancers. Since KSHV encodes a number of factors that directly or indirectly manipulate host cell chromatin, it is an intriguing possibility that epigenetic reprogramming also contributes to the pathogenesis of KSHV-associated tumors. The fact that heritable histone modifications have also been shown to regulate viral gene expression programs in KSHV-infected tumor cells underlines the importance of epigenetic control during latency and tumorigenesis. We here review what is presently known about the role of epigenetic regulation of viral and host chromatin in KSHV infection and discuss how viral manipulation of these processes may contribute to the development of KSHV-associated disease.

Plummer M, de Martel C, Vignat J, Ferlay J, Bray F, Franceschi S (2016) Global burden of cancers attributable to infections in 2012: a synthetic analysis. Lancet Glob Health 4(9):e609–e616. https://doi.org/10.1016/S2214-109X(16)30143-7 CrossRefPubMed

Iarc working group on the evaluation of carcinogenic risks to humans (2012) biological agents. Volume 100 B. A review of human carcinogens. IARC Monogr Eval Carcinog Risks Hum 100(Pt B):1–441

Iarc Working Group on the Evaluation of Carcinogenic Risks to Humans (2014) Malaria and some Polyomaviruses (Sv40, Bk, Jc, and Merkel cell viruses). IARC Monogr Eval Carcinog Risks Hum 104:9–350PubMedCentral

Chang Y, Cesarman E, Pessin MS, Lee F, Culpepper J, Knowles DM, Moore PS (1994) Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science 266(5192):1865–1869CrossRef

Kaposi M (1872) Idiopathisches multiples Pigmentsarkom der haut. Arch f Dermat 4(2):9. https://doi.org/10.1007/BF01830024 CrossRef

Silverberg MJ, Lau B, Achenbach CJ, Jing Y, Althoff KN, D'Souza G, Engels EA, Hessol NA, Brooks JT, Burchell AN, Gill MJ, Goedert JJ, Hogg R, Horberg MA, Kirk GD, Kitahata MM, Korthuis PT, Mathews WC, Mayor A, Modur SP, Napravnik S, Novak RM, Patel P, Rachlis AR, Sterling TR, Willig JH, Justice AC, Moore RD, Dubrow R, North American ACCoR, Design of the International Epidemiologic Databases to Evaluate A (2015) Cumulative incidence of cancer among persons with HIV in North America: a cohort study. Ann Intern Med 163(7):507–518. https://doi.org/10.7326/M14-2768 CrossRefPubMedPubMedCentral

Cesarman E, Damania B, Krown SE, Martin J, Bower M, Whitby D (2019) Kaposi sarcoma. Nat Rev Dis Primers 5(1):9. https://doi.org/10.1038/s41572-019-0060-9 CrossRefPubMedPubMedCentral

Kahn HJ, Bailey D, Marks A (2002) Monoclonal antibody D2-40, a new marker of lymphatic endothelium, reacts with Kaposi's sarcoma and a subset of angiosarcomas. Mod Pathol 15(4):434–440. https://doi.org/10.1038/modpathol.3880543 CrossRefPubMed

Pyakurel P, Pak F, Mwakigonja AR, Kaaya E, Heiden T, Biberfeld P (2006) Lymphatic and vascular origin of Kaposi's sarcoma spindle cells during tumor development. Int J Cancer 119(6):1262–1267. https://doi.org/10.1002/ijc.21969 CrossRefPubMed

10.

Li Y, Zhong C, Liu D, Yu W, Chen W, Wang Y, Shi S, Yuan Y (2018) Evidence for Kaposi sarcoma originating from mesenchymal stem cell through KSHV-induced mesenchymal-to-endothelial transition. Cancer Res 78(1):230–245. https://doi.org/10.1158/0008-5472.CAN-17-1961 CrossRefPubMed

11.

Cesarman E, Chang Y, Moore PS, Said JW, Knowles DM (1995) Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas. N Engl J Med 332(18):1186–1191. https://doi.org/10.1056/NEJM199505043321802 CrossRefPubMed

12.

Soulier J, Grollet L, Oksenhendler E, Cacoub P, Cazals-Hatem D, Babinet P, d'Agay MF, Clauvel JP, Raphael M, Degos L et al (1995) Kaposi's sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman's disease. Blood 86(4):1276–1280CrossRef

13.

Cesarman E, Moore PS, Rao PH, Inghirami G, Knowles DM, Chang Y (1995) In vitro establishment and characterization of two acquired immunodeficiency syndrome-related lymphoma cell lines (BC-1 and BC-2) containing Kaposi's sarcoma-associated herpesvirus-like (KSHV) DNA sequences. Blood 86(7):2708–2714CrossRef

14.

Arvanitakis L, Mesri EA, Nador RG, Said JW, Asch AS, Knowles DM, Cesarman E (1996) Establishment and characterization of a primary effusion (body cavity-based) lymphoma cell line (BC-3) harboring kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) in the absence of Epstein-Barr virus. Blood 88(7):2648–2654CrossRef

15.

Renne R, Zhong W, Herndier B, McGrath M, Abbey N, Kedes D, Ganem D (1996) Lytic growth of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in culture. Nat Med 2(3):342–346. https://doi.org/10.1038/nm0396-342 CrossRefPubMed

16.

Uldrick TS, Polizzotto MN, Yarchoan R (2012) Recent advances in Kaposi sarcoma herpesvirus-associated multicentric Castleman disease. Curr Opin Oncol 24(5):495–505. https://doi.org/10.1097/CCO.0b013e328355e0f3 CrossRefPubMedPubMedCentral

17.

Bower M, Nelson M, Young AM, Thirlwell C, Newsom-Davis T, Mandalia S, Dhillon T, Holmes P, Gazzard BG, Stebbing J (2005) Immune reconstitution inflammatory syndrome associated with Kaposi's sarcoma. J Clin Oncol 23(22):5224–5228. https://doi.org/10.1200/JCO.2005.14.597 CrossRefPubMed

18.

Connick E, Kane MA, White IE, Ryder J, Campbell TB (2004) Immune reconstitution inflammatory syndrome associated with Kaposi sarcoma during potent antiretroviral therapy. Clin Infect Dis 39(12):1852–1855. https://doi.org/10.1086/426078 CrossRefPubMed

19.

Polizzotto MN, Uldrick TS, Wyvill KM, Aleman K, Marshall V, Wang V, Whitby D, Pittaluga S, Jaffe ES, Millo C, Tosato G, Little RF, Steinberg SM, Sereti I, Yarchoan R (2016) Clinical features and outcomes of patients with symptomatic Kaposi sarcoma herpesvirus (KSHV)-associated inflammation: prospective characterization of KSHV inflammatory cytokine syndrome (KICS). Clin Infect Dis 62(6):730–738. https://doi.org/10.1093/cid/civ996 CrossRefPubMed

20.

Uldrick TS, Wang V, O'Mahony D, Aleman K, Wyvill KM, Marshall V, Steinberg SM, Pittaluga S, Maric I, Whitby D, Tosato G, Little RF, Yarchoan R (2010) An interleukin-6-related systemic inflammatory syndrome in patients co-infected with Kaposi sarcoma-associated herpesvirus and HIV but without multicentric Castleman disease. Clin Infect Dis 51(3):350–358. https://doi.org/10.1086/654798 CrossRefPubMedPubMedCentral

21.

Cesarman E (2014) How do viruses trick B cells into becoming lymphomas? Curr Opin Hematol 21(4):358–368. https://doi.org/10.1097/MOH.0000000000000060 CrossRefPubMedPubMedCentral

22.

Schulz TF, Cesarman E (2015) Kaposi sarcoma-associated herpesvirus: mechanisms of oncogenesis. Curr Opin Virol 14:116–128. https://doi.org/10.1016/j.coviro.2015.08.016 CrossRefPubMed

23.

Cavallin LE, Goldschmidt-Clermont P, Mesri EA (2014) Molecular and cellular mechanisms of KSHV oncogenesis of Kaposi's sarcoma associated with HIV/AIDS. PLoS Pathog 10(7):e1004154. https://doi.org/10.1371/journal.ppat.1004154 CrossRefPubMedPubMedCentral

24.

Jung J, Munz C (2015) Immune control of oncogenic gamma-herpesviruses. Curr Opin Virol 14:79–86. https://doi.org/10.1016/j.coviro.2015.08.014 CrossRefPubMedPubMedCentral

25.

Günther T, Grundhoff A (2017) Epigenetic manipulation of host chromatin by Kaposi sarcoma-associated herpesvirus: a tumor-promoting factor? Curr Opin Virol 26:104–111. https://doi.org/10.1016/j.coviro.2017.07.018

26.

Wies E, Mori Y, Hahn A, Kremmer E, Sturzl M, Fleckenstein B, Neipel F (2008) The viral interferon-regulatory factor-3 is required for the survival of KSHV-infected primary effusion lymphoma cells. Blood 111(1):320–327. https://doi.org/10.1182/blood-2007-05-092288 CrossRefPubMed

27.

Guasparri I, Keller SA, Cesarman E (2004) KSHV vFLIP is essential for the survival of infected lymphoma cells. J Exp Med 199(7):993–1003. https://doi.org/10.1084/jem.20031467 CrossRefPubMedPubMedCentral

28.

Keller SA, Schattner EJ, Cesarman E (2000) Inhibition of NF-kappaB induces apoptosis of KSHV-infected primary effusion lymphoma cells. Blood 96(7):2537–2542CrossRef

29.

Brimo F, Michel RP, Khetani K, Auger M (2007) Primary effusion lymphoma: a series of 4 cases and review of the literature with emphasis on cytomorphologic and immunocytochemical differential diagnosis. Cancer 111(4):224–233. https://doi.org/10.1002/cncr.22691 CrossRefPubMed

30.

Katano H, Sato Y, Sata T (2001) Expression of p53 and human herpesvirus-8 (HHV-8)-encoded latency-associated nuclear antigen with inhibition of apoptosis in HHV-8-associated malignancies. Cancer 92(12):3076–3084. https://doi.org/10.1002/1097-0142(20011215)92:12<3076::aid-cncr10117>3.0.co;2-d CrossRefPubMed

31.

Petre CE, Sin SH, Dittmer DP (2007) Functional p53 signaling in Kaposi's sarcoma-associated herpesvirus lymphomas: implications for therapy. J Virol 81(4):1912–1922. https://doi.org/10.1128/JVI.01757-06 CrossRefPubMed

32.

Li JJ, Huang YQ, Cockerell CJ, Zhang WG, Nicolaides A, Friedman-Kien AE (1997) Expression and mutation of the tumor suppressor gene p53 in AIDS-associated Kaposi's sarcoma. Am J Dermatopathol 19(4):373–378. https://doi.org/10.1097/00000372-199708000-00009 CrossRefPubMed

33.

Scinicariello F, Dolan MJ, Nedelcu I, Tyring SK, Hilliard JK (1994) Occurrence of human papillomavirus and p53 gene mutations in Kaposi's sarcoma. Virology 203(1):153–157. https://doi.org/10.1006/viro.1994.1466 CrossRefPubMed

34.

Nicolaides A, Huang YQ, Li JJ, Zhang WG, Friedman-Kien AE (1994) Gene amplification and multiple mutations of the K-ras oncogene in Kaposi's sarcoma. Anticancer Res 14(3A):921–926PubMed

35.

Hu J, Garber AC, Renne R (2002) The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus supports latent DNA replication in dividing cells. J Virol 76(22):11677–11687. https://doi.org/10.1128/jvi.76.22.11677-11687.2002 CrossRefPubMedPubMedCentral

36.

Grundhoff A, Ganem D (2003) The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus permits replication of terminal repeat-containing plasmids. J Virol 77(4):2779–2783. https://doi.org/10.1128/jvi.77.4.2779-2783.2003 CrossRefPubMedPubMedCentral

37.

Ballestas ME, Chatis PA, Kaye KM (1999) Efficient persistence of extrachromosomal KSHV DNA mediated by latency-associated nuclear antigen. Science 284(5414):641–644. https://doi.org/10.1126/science.284.5414.641 CrossRefPubMed

38.

Barbera AJ, Chodaparambil JV, Kelley-Clarke B, Joukov V, Walter JC, Luger K, Kaye KM (2006) The nucleosomal surface as a docking station for Kaposi's sarcoma herpesvirus LANA. Science 311(5762):856–861. https://doi.org/10.1126/science.1120541 CrossRefPubMed

39.

Lim C, Sohn H, Lee D, Gwack Y, Choe J (2002) Functional dissection of latency-associated nuclear antigen 1 of Kaposi's sarcoma-associated herpesvirus involved in latent DNA replication and transcription of terminal repeats of the viral genome. J Virol 76(20):10320–10331. https://doi.org/10.1128/jvi.76.20.10320-10331.2002 CrossRefPubMedPubMedCentral

40.

Stedman W, Deng Z, Lu F, Lieberman PM (2004) ORC, MCM, and histone hyperacetylation at the Kaposi's sarcoma-associated herpesvirus latent replication origin. J Virol 78(22):12566–12575. https://doi.org/10.1128/JVI.78.22.12566-12575.2004 CrossRefPubMedPubMedCentral

41.

Cotter MA 2nd, Robertson ES (1999) The latency-associated nuclear antigen tethers the Kaposi's sarcoma-associated herpesvirus genome to host chromosomes in body cavity-based lymphoma cells. Virology 264(2):254–264. https://doi.org/10.1006/viro.1999.9999 CrossRefPubMed

42.

Krithivas A, Fujimuro M, Weidner M, Young DB, Hayward SD (2002) Protein interactions targeting the latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus to cell chromosomes. J Virol 76(22):11596–11604. https://doi.org/10.1128/jvi.76.22.11596-11604.2002 CrossRefPubMedPubMedCentral

43.

Xiao B, Verma SC, Cai Q, Kaul R, Lu J, Saha A, Robertson ES (2010) Bub1 and CENP-F can contribute to Kaposi's sarcoma-associated herpesvirus genome persistence by targeting LANA to kinetochores. J Virol 84(19):9718–9732. https://doi.org/10.1128/JVI.00713-10 CrossRefPubMedPubMedCentral

44.

Viejo-Borbolla A, Ottinger M, Bruning E, Burger A, Konig R, Kati E, Sheldon JA, Schulz TF (2005) Brd2/RING3 interacts with a chromatin-binding domain in the Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen 1 (LANA-1) that is required for multiple functions of LANA-1. J Virol 79(21):13618–13629. https://doi.org/10.1128/JVI.79.21.13618-13629.2005 CrossRefPubMedPubMedCentral

45.

You J, Srinivasan V, Denis GV, Harrington WJ Jr, Ballestas ME, Kaye KM, Howley PM (2006) Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen interacts with bromodomain protein Brd4 on host mitotic chromosomes. J Virol 80(18):8909–8919. https://doi.org/10.1128/JVI.00502-06 CrossRefPubMedPubMedCentral

46.

Friborg J Jr, Kong W, Hottiger MO, Nabel GJ (1999) p53 inhibition by the LANA protein of KSHV protects against cell death. Nature 402(6764):889–894. https://doi.org/10.1038/47266 CrossRefPubMed

47.

Radkov SA, Kellam P, Boshoff C (2000) The latent nuclear antigen of Kaposi sarcoma-associated herpesvirus targets the retinoblastoma-E2F pathway and with the oncogene Hras transforms primary rat cells. Nat Med 6(10):1121–1127. https://doi.org/10.1038/80459 CrossRefPubMed

48.

Fujimuro M, Wu FY, ApRhys C, Kajumbula H, Young DB, Hayward GS, Hayward SD (2003) A novel viral mechanism for dysregulation of beta-catenin in Kaposi's sarcoma-associated herpesvirus latency. Nat Med 9(3):300–306. https://doi.org/10.1038/nm829 CrossRefPubMed

49.

Chang Y, Moore PS, Talbot SJ, Boshoff CH, Zarkowska T, Godden K, Paterson H, Weiss RA, Mittnacht S (1996) Cyclin encoded by KS herpesvirus. Nature 382(6590):410. https://doi.org/10.1038/382410a0 CrossRefPubMed

50.

Godden-Kent D, Talbot SJ, Boshoff C, Chang Y, Moore P, Weiss RA, Mittnacht S (1997) The cyclin encoded by Kaposi's sarcoma-associated herpesvirus stimulates cdk6 to phosphorylate the retinoblastoma protein and histone H1. J Virol 71(6):4193–4198CrossRef

51.

Li M, Lee H, Yoon DW, Albrecht JC, Fleckenstein B, Neipel F, Jung JU (1997) Kaposi's sarcoma-associated herpesvirus encodes a functional cyclin. J Virol 71(3):1984–1991CrossRef

52.

Jarviluoma A, Koopal S, Rasanen S, Makela TP, Ojala PM (2004) KSHV viral cyclin binds to p27KIP1 in primary effusion lymphomas. Blood 104(10):3349–3354. https://doi.org/10.1182/blood-2004-05-1798 CrossRefPubMed

53.

Chaudhary PM, Jasmin A, Eby MT, Hood L (1999) Modulation of the NF-kappa B pathway by virally encoded death effector domains-containing proteins. Oncogene 18(42):5738–5746. https://doi.org/10.1038/sj.onc.1202976 CrossRefPubMed

54.

Matta H, Sun Q, Moses G, Chaudhary PM (2003) Molecular genetic analysis of human herpes virus 8-encoded viral FLICE inhibitory protein-induced NF-kappaB activation. J Biol Chem 278(52):52406–52411. https://doi.org/10.1074/jbc.M307308200 CrossRefPubMed

55.

Sun Q, Matta H, Chaudhary PM (2003) The human herpes virus 8-encoded viral FLICE inhibitory protein protects against growth factor withdrawal-induced apoptosis via NF-kappa B activation. Blood 101(5):1956–1961. https://doi.org/10.1182/blood-2002-07-2072 CrossRefPubMed

56.

Sun Q, Zachariah S, Chaudhary PM (2003) The human herpes virus 8-encoded viral FLICE-inhibitory protein induces cellular transformation via NF-kappaB activation. J Biol Chem 278(52):52437–52445. https://doi.org/10.1074/jbc.M304199200 CrossRefPubMed

57.

Pfeffer S, Sewer A, Lagos-Quintana M, Sheridan R, Sander C, Grasser FA, van Dyk LF, Ho CK, Shuman S, Chien M, Russo JJ, Ju J, Randall G, Lindenbach BD, Rice CM, Simon V, Ho DD, Zavolan M, Tuschl T (2005) Identification of microRNAs of the herpesvirus family. Nat Methods 2(4):269–276. https://doi.org/10.1038/nmeth746 CrossRefPubMed

58.

Samols MA, Hu J, Skalsky RL, Renne R (2005) Cloning and identification of a microRNA cluster within the latency-associated region of Kaposi's sarcoma-associated herpesvirus. J Virol 79(14):9301–9305. https://doi.org/10.1128/JVI.79.14.9301-9305.2005 CrossRefPubMedPubMedCentral

59.

Cai X, Lu S, Zhang Z, Gonzalez CM, Damania B, Cullen BR (2005) Kaposi's sarcoma-associated herpesvirus expresses an array of viral microRNAs in latently infected cells. Proc Natl Acad Sci U S A 102(15):5570–5575. https://doi.org/10.1073/pnas.0408192102 CrossRefPubMedPubMedCentral

60.

Grundhoff A, Sullivan CS, Ganem D (2006) A combined computational and microarray-based approach identifies novel microRNAs encoded by human gamma-herpesviruses. RNA 12(5):733–750. https://doi.org/10.1261/rna.2326106 CrossRefPubMedPubMedCentral

61.

Grundhoff A, Sullivan CS (2011) Virus-encoded microRNAs. Virology 411(2):325–343. https://doi.org/10.1016/j.virol.2011.01.002 CrossRefPubMedPubMedCentral

62.

Zhu Y, Haecker I, Yang Y, Gao SJ, Renne R (2013) Gamma-herpesvirus-encoded miRNAs and their roles in viral biology and pathogenesis. Curr Opin Virol 3(3):266–275. https://doi.org/10.1016/j.coviro.2013.05.013 CrossRefPubMed

63.

Qin J, Li W, Gao SJ, Lu C (2017) KSHV microRNAs: tricks of the devil. Trends Microbiol 25(8):648–661. https://doi.org/10.1016/j.tim.2017.02.002 CrossRefPubMedPubMedCentral

64.

Gottwein E, Mukherjee N, Sachse C, Frenzel C, Majoros WH, Chi JT, Braich R, Manoharan M, Soutschek J, Ohler U, Cullen BR (2007) A viral microRNA functions as an orthologue of cellular miR-155. Nature 450(7172):1096–1099. https://doi.org/10.1038/nature05992 CrossRefPubMedPubMedCentral

65.

Skalsky RL, Samols MA, Plaisance KB, Boss IW, Riva A, Lopez MC, Baker HV, Renne R (2007) Kaposi's sarcoma-associated herpesvirus encodes an ortholog of miR-155. J Virol 81(23):12836–12845. https://doi.org/10.1128/JVI.01804-07 CrossRefPubMedPubMedCentral

66.

Boss IW, Nadeau PE, Abbott JR, Yang Y, Mergia A, Renne R (2011) A Kaposi's sarcoma-associated herpesvirus-encoded ortholog of microRNA miR-155 induces human splenic B-cell expansion in NOD/LtSz-scid IL2Rgammanull mice. J Virol 85(19):9877–9886. https://doi.org/10.1128/JVI.05558-11 CrossRefPubMedPubMedCentral

67.

Dahlke C, Maul K, Christalla T, Walz N, Schult P, Stocking C, Grundhoff A (2012) A microRNA encoded by Kaposi sarcoma-associated herpesvirus promotes B-cell expansion in vivo. PLoS One 7(11):e49435. https://doi.org/10.1371/journal.pone.0049435 CrossRefPubMedPubMedCentral

68.

Dittmer D, Lagunoff M, Renne R, Staskus K, Haase A, Ganem D (1998) A cluster of latently expressed genes in Kaposi's sarcoma-associated herpesvirus. J Virol 72(10):8309–8315CrossRef

69.

Sadler R, Wu L, Forghani B, Renne R, Zhong W, Herndier B, Ganem D (1999) A complex translational program generates multiple novel proteins from the latently expressed kaposin (K12) locus of Kaposi's sarcoma-associated herpesvirus. J Virol 73(7):5722–5730CrossRef

70.

Rivas C, Thlick AE, Parravicini C, Moore PS, Chang Y (2001) Kaposi's sarcoma-associated herpesvirus LANA2 is a B-cell-specific latent viral protein that inhibits p53. J Virol 75(1):429–438. https://doi.org/10.1128/JVI.75.1.429-438.2001 CrossRefPubMedPubMedCentral

71.

Parravicini C, Chandran B, Corbellino M, Berti E, Paulli M, Moore PS, Chang Y (2000) Differential viral protein expression in Kaposi's sarcoma-associated herpesvirus-infected diseases: Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease. Am J Pathol 156(3):743–749. https://doi.org/10.1016/S0002-9440(10)64940-1 CrossRefPubMedPubMedCentral

72.

Katano H, Sato Y, Kurata T, Mori S, Sata T (2000) Expression and localization of human herpesvirus 8-encoded proteins in primary effusion lymphoma, Kaposi's sarcoma, and multicentric Castleman's disease. Virology 269(2):335–344. https://doi.org/10.1006/viro.2000.0196 CrossRefPubMed

73.

Koch S, Schulz TF (2017) Rhadinoviral interferon regulatory factor homologues. Biol Chem 398(8):857–870. https://doi.org/10.1515/hsz-2017-0111 CrossRefPubMed

74.

Moore PS, Boshoff C, Weiss RA, Chang Y (1996) Molecular mimicry of human cytokine and cytokine response pathway genes by KSHV. Science 274(5293):1739–1744. https://doi.org/10.1126/science.274.5293.1739 CrossRefPubMed

75.

Cesarman E, Nador RG, Bai F, Bohenzky RA, Russo JJ, Moore PS, Chang Y, Knowles DM (1996) Kaposi's sarcoma-associated herpesvirus contains G protein-coupled receptor and cyclin D homologs which are expressed in Kaposi's sarcoma and malignant lymphoma. J Virol 70(11):8218–8223CrossRef

76.

Cannon M (2007) The KSHV and other human herpesviral G protein-coupled receptors. Curr Top Microbiol Immunol 312:137–156. https://doi.org/10.1007/978-3-540-34344-8_5 CrossRefPubMed

77.

Abere B, Schulz TF (2016) KSHV non-structural membrane proteins involved in the activation of intracellular signaling pathways and the pathogenesis of Kaposi's sarcoma. Curr Opin Virol 20:11–19. https://doi.org/10.1016/j.coviro.2016.07.008 CrossRefPubMed

78.

Bowser BS, DeWire SM, Damania B (2002) Transcriptional regulation of the K1 gene product of Kaposi's sarcoma-associated herpesvirus. J Virol 76(24):12574–12583. https://doi.org/10.1128/jvi.76.24.12574-12583.2002 CrossRefPubMedPubMedCentral

79.

Bowser BS, Morris S, Song MJ, Sun R, Damania B (2006) Characterization of Kaposi's sarcoma-associated herpesvirus (KSHV) K1 promoter activation by Rta. Virology 348(2):309–327. https://doi.org/10.1016/j.virol.2006.02.007 CrossRefPubMed

80.

Chandriani S, Ganem D (2010) Array-based transcript profiling and limiting-dilution reverse transcription-PCR analysis identify additional latent genes in Kaposi's sarcoma-associated herpesvirus. J Virol 84(11):5565–5573. https://doi.org/10.1128/JVI.02723-09 CrossRefPubMedPubMedCentral

81.

Wang L, Dittmer DP, Tomlinson CC, Fakhari FD, Damania B (2006) Immortalization of primary endothelial cells by the K1 protein of Kaposi's sarcoma-associated herpesvirus. Cancer Res 66(7):3658–3666. https://doi.org/10.1158/0008-5472.CAN-05-3680 CrossRefPubMed

82.

Chang HH, Ganem D (2013) A unique herpesviral transcriptional program in KSHV-infected lymphatic endothelial cells leads to mTORC1 activation and rapamycin sensitivity. Cell Host Microbe 13(4):429–440. https://doi.org/10.1016/j.chom.2013.03.009 CrossRefPubMedPubMedCentral

83.

Huang C, Xu M, Zhu B (2013) Epigenetic inheritance mediated by histone lysine methylation: maintaining transcriptional states without the precise restoration of marks? Philos Trans R Soc Lond Ser B Biol Sci 368(1609):20110332. https://doi.org/10.1098/rstb.2011.0332 CrossRef

84.

Annunziato AT (2015) The fork in the road: histone partitioning during DNA replication. Genes (Basel) 6(2):353–371. https://doi.org/10.3390/genes6020353 CrossRef

85.

Petruk S, Sedkov Y, Johnston DM, Hodgson JW, Black KL, Kovermann SK, Beck S, Canaani E, Brock HW, Mazo A (2012) TrxG and PcG proteins but not methylated histones remain associated with DNA through replication. Cell 150(5):922–933. https://doi.org/10.1016/j.cell.2012.06.046 CrossRefPubMedPubMedCentral

86.

Aranda S, Mas G, Di Croce L (2015) Regulation of gene transcription by Polycomb proteins. Sci Adv 1(11):e1500737. https://doi.org/10.1126/sciadv.1500737 CrossRefPubMedPubMedCentral

87.

Ramachandran S, Henikoff S (2015) Replicating nucleosomes. Sci Adv 1(7). https://doi.org/10.1126/sciadv.1500587

88.

Campos EI, Stafford JM, Reinberg D (2014) Epigenetic inheritance: histone bookmarks across generations. Trends Cell Biol 24(11):664–674. https://doi.org/10.1016/j.tcb.2014.08.004 CrossRefPubMedPubMedCentral

89.

Moussa HF, Bsteh D, Yelagandula R, Pribitzer C, Stecher K, Bartalska K, Michetti L, Wang J, Zepeda-Martinez JA, Elling U, Stuckey JI, James LI, Frye SV, Bell O (2019) Canonical PRC1 controls sequence-independent propagation of polycomb-mediated gene silencing. Nat Commun 10(1):1931–1912. https://doi.org/10.1038/s41467-019-09628-6 CrossRefPubMedPubMedCentral

90.

Yu JR, Lee CH, Oksuz O, Stafford JM, Reinberg D (2019) PRC2 is high maintenance. Genes Dev 33(15–16):903–935. https://doi.org/10.1101/gad.325050.119 CrossRefPubMedPubMedCentral

91.

Laugesen A, Helin K (2014) Chromatin repressive complexes in stem cells, development, and cancer. Cell Stem Cell 14(6):735–751. https://doi.org/10.1016/j.stem.2014.05.006 CrossRefPubMed

92.

Di Croce L, Helin K (2013) Transcriptional regulation by Polycomb group proteins. Nat Struct Mol Biol 20(10):1147–1155. https://doi.org/10.1038/nsmb.2669 CrossRefPubMed

93.

Schuettengruber B, Bourbon HM, Di Croce L, Cavalli G (2017) Genome regulation by polycomb and trithorax: 70 years and counting. Cell 171(1):34–57. https://doi.org/10.1016/j.cell.2017.08.002 CrossRefPubMed

94.

Gunther T, Schreiner S, Dobner T, Tessmer U, Grundhoff A (2014) Influence of ND10 components on epigenetic determinants of early KSHV latency establishment. PLoS Pathog 10(7):e1004274. https://doi.org/10.1371/journal.ppat.1004274 CrossRefPubMedPubMedCentral

95.

Gunther T, Grundhoff A (2010) The epigenetic landscape of latent Kaposi sarcoma-associated herpesvirus genomes. PLoS Pathog 6(6):e1000935. https://doi.org/10.1371/journal.ppat.1000935 CrossRefPubMedPubMedCentral

96.

Toth Z, Maglinte DT, Lee SH, Lee HR, Wong LY, Brulois KF, Lee S, Buckley JD, Laird PW, Marquez VE, Jung JU (2010) Epigenetic analysis of KSHV latent and lytic genomes. PLoS Pathog 6(7):e1001013. https://doi.org/10.1371/journal.ppat.1001013 CrossRefPubMedPubMedCentral

97.

Toth Z, Brulois K, Lee HR, Izumiya Y, Tepper C, Kung HJ, Jung JU (2013) Biphasic euchromatin-to-heterochromatin transition on the KSHV genome following de novo infection. PLoS Pathog 9(12):e1003813. https://doi.org/10.1371/journal.ppat.1003813 CrossRefPubMedPubMedCentral

98.

Gunther T, Frohlich J, Herrde C, Ohno S, Burkhardt L, Adler H, Grundhoff A (2019) A comparative epigenome analysis of gammaherpesviruses suggests cis-acting sequence features as critical mediators of rapid polycomb recruitment. PLoS Pathog 15(10):e1007838. https://doi.org/10.1371/journal.ppat.1007838 CrossRefPubMedPubMedCentral

99.

Grundhoff A, Ganem D (2004) Inefficient establishment of KSHV latency suggests an additional role for continued lytic replication in Kaposi sarcoma pathogenesis. J Clin Invest 113(1):124–136. https://doi.org/10.1172/JCI17803 CrossRefPubMedPubMedCentral

100.

Krishnan HH, Naranatt PP, Smith MS, Zeng L, Bloomer C, Chandran B (2004) Concurrent expression of latent and a limited number of lytic genes with immune modulation and antiapoptotic function by Kaposi's sarcoma-associated herpesvirus early during infection of primary endothelial and fibroblast cells and subsequent decline of lytic gene expression. J Virol 78(7):3601–3620CrossRef

101.

Kar G, Kim JK, Kolodziejczyk AA, Natarajan KN, Torlai Triglia E, Mifsud B, Elderkin S, Marioni JC, Pombo A, Teichmann SA (2017) Flipping between polycomb repressed and active transcriptional states introduces noise in gene expression. Nat Commun 8(1):36. https://doi.org/10.1038/s41467-017-00052-2 CrossRefPubMedPubMedCentral

102.

Harikumar A, Meshorer E (2015) Chromatin remodeling and bivalent histone modifications in embryonic stem cells. EMBO Rep 16(12):1609–1619. https://doi.org/10.15252/embr.201541011 CrossRefPubMedPubMedCentral

103.

Abere B, Mamo TM, Hartmann S, Samarina N, Hage E, Ruckert J, Hotop SK, Busche G, Schulz TF (2017) The Kaposi's sarcoma-associated herpesvirus (KSHV) non-structural membrane protein K15 is required for viral lytic replication and may represent a therapeutic target. PLoS Pathog 13(9):e1006639. https://doi.org/10.1371/journal.ppat.1006639 CrossRefPubMedPubMedCentral

104.

Sharp TV, Wang HW, Koumi A, Hollyman D, Endo Y, Ye H, Du MQ, Boshoff C (2002) K15 protein of Kaposi's sarcoma-associated herpesvirus is latently expressed and binds to HAX-1, a protein with antiapoptotic function. J Virol 76(2):802–816. https://doi.org/10.1128/jvi.76.2.802-816.2002 CrossRefPubMedPubMedCentral

105.

Blackledge NP, Rose NR, Klose RJ (2015) Targeting polycomb systems to regulate gene expression: modifications to a complex story. Nat Rev Mol Cell Biol 16(11):643–649. https://doi.org/10.1038/nrm4067 CrossRefPubMedPubMedCentral

106.

Perino M, van Mierlo G, Karemaker ID, van Genesen S, Vermeulen M, Marks H, van Heeringen SJ, Veenstra GJC (2018) MTF2 recruits Polycomb repressive complex 2 by helical-shape-selective DNA binding. Nat Genet 50(7):1002–1010. https://doi.org/10.1038/s41588-018-0134-8 CrossRefPubMed

107.

Li H, Liefke R, Jiang J, Kurland JV, Tian W, Deng P, Zhang W, He Q, Patel DJ, Bulyk ML, Shi Y, Wang Z (2017) Polycomb-like proteins link the PRC2 complex to CpG islands. Nature 549(7671):287–291. https://doi.org/10.1038/nature23881 CrossRefPubMedPubMedCentral

108.

Choi J, Bachmann AL, Tauscher K, Benda C, Fierz B, Muller J (2017) DNA binding by PHF1 prolongs PRC2 residence time on chromatin and thereby promotes H3K27 methylation. Nat Struct Mol Biol 24(12):1039–1047. https://doi.org/10.1038/nsmb.3488 CrossRefPubMed

109.

Riising EM, Comet I, Leblanc B, Wu X, Johansen JV, Helin K (2014) Gene silencing triggers polycomb repressive complex 2 recruitment to CpG islands genome wide. Mol Cell 55(3):347–360. https://doi.org/10.1016/j.molcel.2014.06.005 CrossRefPubMed

110.

Wu X, Johansen JV, Helin K (2013) Fbxl10/Kdm2b recruits polycomb repressive complex 1 to CpG islands and regulates H2A ubiquitylation. Mol Cell 49(6):1134–1146. https://doi.org/10.1016/j.molcel.2013.01.016 CrossRefPubMed

111.

He J, Shen L, Wan M, Taranova O, Wu H, Zhang Y (2013) Kdm2b maintains murine embryonic stem cell status by recruiting PRC1 complex to CpG islands of developmental genes. Nat Cell Biol 15(4):373–384. https://doi.org/10.1038/ncb2702 CrossRefPubMedPubMedCentral

112.

Blackledge NP, Farcas AM, Kondo T, King HW, McGouran JF, Hanssen LL, Ito S, Cooper S, Kondo K, Koseki Y, Ishikura T, Long HK, Sheahan TW, Brockdorff N, Kessler BM, Koseki H, Klose RJ (2014) Variant PRC1 complex-dependent H2A ubiquitylation drives PRC2 recruitment and polycomb domain formation. Cell 157(6):1445–1459. https://doi.org/10.1016/j.cell.2014.05.004 CrossRefPubMedPubMedCentral

113.

Farcas AM, Blackledge NP, Sudbery I, Long HK, McGouran JF, Rose NR, Lee S, Sims D, Cerase A, Sheahan TW, Koseki H, Brockdorff N, Ponting CP, Kessler BM, Klose RJ (2012) KDM2B links the polycomb repressive complex 1 (PRC1) to recognition of CpG islands. Elife 1:e00205. https://doi.org/10.7554/eLife.00205 CrossRefPubMedPubMedCentral

114.

van Kruijsbergen I, Hontelez S, Veenstra GJ (2015) Recruiting polycomb to chromatin. Int J Biochem Cell Biol 67:177–187. https://doi.org/10.1016/j.biocel.2015.05.006 CrossRefPubMedPubMedCentral

115.

Toth Z, Papp B, Brulois K, Choi YJ, Gao SJ, Jung JU (2016) LANA-mediated recruitment of host Polycomb repressive complexes onto the KSHV genome during De novo infection. PLoS Pathog 12(9):e1005878. https://doi.org/10.1371/journal.ppat.1005878 CrossRefPubMedPubMedCentral

116.

Gupta N, Thakker S, Verma SC (2016) KSHV encoded LANA recruits nucleosome assembly protein NAP1L1 for regulating viral DNA replication and transcription. Sci Rep 6:32633. https://doi.org/10.1038/srep32633 CrossRefPubMedPubMedCentral

117.

Thakker S, Purushothaman P, Gupta N, Challa S, Cai Q, Verma SC (2015) Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen inhibits major histocompatibility complex class II expression by disrupting Enhanceosome assembly through binding with the regulatory factor X complex. J Virol 89(10):5536–5556. https://doi.org/10.1128/JVI.03713-14 CrossRefPubMedPubMedCentral

118.

Hu J, Yang Y, Turner PC, Jain V, McIntyre LM, Renne R (2014) LANA binds to multiple active viral and cellular promoters and associates with the H3K4methyltransferase hSET1 complex. PLoS Pathog 10(7):e1004240. https://doi.org/10.1371/journal.ppat.1004240 CrossRefPubMedPubMedCentral

119.

Szekely L, Kiss C, Mattsson K, Kashuba E, Pokrovskaja K, Juhasz A, Holmvall P, Klein G (1999) Human herpesvirus-8-encoded LNA-1 accumulates in heterochromatin- associated nuclear bodies. J Gen Virol 80(Pt 11):2889–2900. https://doi.org/10.1099/0022-1317-80-11-2889 CrossRefPubMed

120.

Di Bartolo DL, Cannon M, Liu YF, Renne R, Chadburn A, Boshoff C, Cesarman E (2008) KSHV LANA inhibits TGF-beta signaling through epigenetic silencing of the TGF-beta type II receptor. Blood 111(9):4731–4740. https://doi.org/10.1182/blood-2007-09-110544 CrossRefPubMedPubMedCentral

121.

Shamay M, Krithivas A, Zhang J, Hayward SD (2006) Recruitment of the de novo DNA methyltransferase Dnmt3a by Kaposi's sarcoma-associated herpesvirus LANA. Proc Natl Acad Sci U S A 103(39):14554–14559. https://doi.org/10.1073/pnas.0604469103 CrossRefPubMedPubMedCentral

122.

Kim KY, Huerta SB, Izumiya C, Wang DH, Martinez A, Shevchenko B, Kung HJ, Campbell M, Izumiya Y (2013) Kaposi's sarcoma-associated herpesvirus (KSHV) latency-associated nuclear antigen regulates the KSHV epigenome by association with the histone demethylase KDM3A. J Virol 87(12):6782–6793. https://doi.org/10.1128/JVI.00011-13 CrossRefPubMedPubMedCentral

123.

Sakakibara S, Ueda K, Nishimura K, Do E, Ohsaki E, Okuno T, Yamanishi K (2004) Accumulation of heterochromatin components on the terminal repeat sequence of Kaposi's sarcoma-associated herpesvirus mediated by the latency-associated nuclear antigen. J Virol 78(14):7299–7310. https://doi.org/10.1128/JVI.78.14.7299-7310.2004 CrossRefPubMedPubMedCentral

124.

Lim C, Lee D, Seo T, Choi C, Choe J (2003) Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus functionally interacts with heterochromatin protein 1. J Biol Chem 278(9):7397–7405. https://doi.org/10.1074/jbc.M211912200 CrossRefPubMed

125.

Sun R, Liang D, Gao Y, Lan K (2014) Kaposi's sarcoma-associated herpesvirus-encoded LANA interacts with host KAP1 to facilitate establishment of viral latency. J Virol 88(13):7331–7344. https://doi.org/10.1128/JVI.00596-14 CrossRefPubMedPubMedCentral

126.

Stuber G, Mattsson K, Flaberg E, Kati E, Markasz L, Sheldon JA, Klein G, Schulz TF, Szekely L (2007) HHV-8 encoded LANA-1 alters the higher organization of the cell nucleus. Mol Cancer 6:28. https://doi.org/10.1186/1476-4598-6-28 CrossRefPubMedPubMedCentral

127.

Ottinger M, Christalla T, Nathan K, Brinkmann MM, Viejo-Borbolla A, Schulz TF (2006) Kaposi's sarcoma-associated herpesvirus LANA-1 interacts with the short variant of BRD4 and releases cells from a BRD4- and BRD2/RING3-induced G1 cell cycle arrest. J Virol 80(21):10772–10786. https://doi.org/10.1128/JVI.00804-06 CrossRefPubMedPubMedCentral

128.

Chen HS, De Leo A, Wang Z, Kerekovic A, Hills R, Lieberman PM (2017) BET-inhibitors disrupt Rad21-dependent conformational control of KSHV latency. PLoS Pathog 13(1):e1006100. https://doi.org/10.1371/journal.ppat.1006100 CrossRefPubMedPubMedCentral

129.

Lang F, Sun Z, Pei Y, Singh RK, Jha HC, Robertson ES (2018) Shugoshin 1 is dislocated by KSHV-encoded LANA inducing aneuploidy. PLoS Pathog 14(9):e1007253. https://doi.org/10.1371/journal.ppat.1007253 CrossRefPubMedPubMedCentral

130.

He M, Zhang W, Bakken T, Schutten M, Toth Z, Jung JU, Gill P, Cannon M, Gao SJ (2012) Cancer angiogenesis induced by Kaposi sarcoma-associated herpesvirus is mediated by EZH2. Cancer Res 72(14):3582–3592. https://doi.org/10.1158/0008-5472.CAN-11-2876 CrossRefPubMedPubMedCentral

131.

Lu F, Stedman W, Yousef M, Renne R, Lieberman PM (2010) Epigenetic regulation of Kaposi's sarcoma-associated herpesvirus latency by virus-encoded microRNAs that target Rta and the cellular Rbl2-DNMT pathway. J Virol 84(6):2697–2706. https://doi.org/10.1128/JVI.01997-09 CrossRefPubMedPubMedCentral

132.

Lee HR, Li F, Choi UY, Yu HR, Aldrovandi GM, Feng P, Gao SJ, Hong YK, Jung JU (2018) Deregulation of HDAC5 by viral interferon regulatory factor 3 plays an essential role in Kaposi's sarcoma-associated Herpesvirus-induced Lymphangiogenesis. MBio 9(1). https://doi.org/10.1128/mBio.02217-17

133.

Wu J, Xu Y, Mo D, Huang P, Sun R, Huang L, Pan S, Xu J (2014) Kaposi's sarcoma-associated herpesvirus (KSHV) vIL-6 promotes cell proliferation and migration by upregulating DNMT1 via STAT3 activation. PLoS One 9(3):e93478. https://doi.org/10.1371/journal.pone.0093478 CrossRefPubMedPubMedCentral

134.

Li W, Wang Q, Feng Q, Wang F, Yan Q, Gao SJ, Lu C (2019) Oncogenic KSHV-encoded interferon regulatory factor upregulates HMGB2 and CMPK1 expression to promote cell invasion by disrupting a complex lncRNA-OIP5-AS1/miR-218-5p network. PLoS Pathog 15(1):e1007578. https://doi.org/10.1371/journal.ppat.1007578 CrossRefPubMedPubMedCentral

135.

Rossetto CC, Pari G (2012) KSHV PAN RNA associates with demethylases UTX and JMJD3 to activate lytic replication through a physical interaction with the virus genome. PLoS Pathog 8(5):e1002680. https://doi.org/10.1371/journal.ppat.1002680 CrossRefPubMedPubMedCentral

136.

Rossetto CC, Tarrant-Elorza M, Verma S, Purushothaman P, Pari GS (2013) Regulation of viral and cellular gene expression by Kaposi's sarcoma-associated herpesvirus polyadenylated nuclear RNA. J Virol 87(10):5540–5553. https://doi.org/10.1128/JVI.03111-12 CrossRefPubMedPubMedCentral

137.

Rossetto CC, Pari GS (2011) Kaposi's sarcoma-associated herpesvirus noncoding polyadenylated nuclear RNA interacts with virus- and host cell-encoded proteins and suppresses expression of genes involved in immune modulation. J Virol 85(24):13290–13297. https://doi.org/10.1128/JVI.05886-11 CrossRefPubMedPubMedCentral

138.

Papp B, Motlagh N, Smindak RJ, Jin Jang S, Sharma A, Alonso JD, Toth Z (2019) Genome-wide identification of direct RTA targets reveals key host factors for Kaposi's sarcoma-associated Herpesvirus lytic reactivation. J Virol 93(5). https://doi.org/10.1128/JVI.01978-18

139.

Mercier A, Arias C, Madrid AS, Holdorf MM, Ganem D (2014) Site-specific association with host and viral chromatin by Kaposi's sarcoma-associated herpesvirus LANA and its reversal during lytic reactivation. J Virol 88(12):6762–6777. https://doi.org/10.1128/JVI.00268-14 CrossRefPubMedPubMedCentral

140.

Lu F, Tsai K, Chen HS, Wikramasinghe P, Davuluri RV, Showe L, Domsic J, Marmorstein R, Lieberman PM (2012) Identification of host-chromosome binding sites and candidate gene targets for Kaposi's sarcoma-associated herpesvirus LANA. J Virol 86(10):5752–5762. https://doi.org/10.1128/JVI.07216-11 CrossRefPubMedPubMedCentral

141.

Hellert J, Weidner-Glunde M, Krausze J, Richter U, Adler H, Fedorov R, Pietrek M, Ruckert J, Ritter C, Schulz TF, Luhrs T (2013) A structural basis for BRD2/4-mediated host chromatin interaction and oligomer assembly of Kaposi sarcoma-associated herpesvirus and murine gammaherpesvirus LANA proteins. PLoS Pathog 9(10):e1003640. https://doi.org/10.1371/journal.ppat.1003640 CrossRefPubMedPubMedCentral

142.

Escobar TM, Kanellopoulou C, Kugler DG, Kilaru G, Nguyen CK, Nagarajan V, Bhairavabhotla RK, Northrup D, Zahr R, Burr P, Liu X, Zhao K, Sher A, Jankovic D, Zhu J, Muljo SA (2014) miR-155 activates cytokine gene expression in Th17 cells by regulating the DNA-binding protein Jarid2 to relieve polycomb-mediated repression. Immunity 40(6):865–879. https://doi.org/10.1016/j.immuni.2014.03.014 CrossRefPubMedPubMedCentral

143.

Naipauer J, Rosario S, Gupta S, Premer C, Mendez-Solis O, Schlesinger M, Ponzinibbio V, Jain V, Gay L, Renne R, Chan HL, Morey L, Salyakina D, Abba M, Williams S, Hare JM, Goldschmidt-Clermont PJ, Mesri EA (2019) PDGFRA defines the mesenchymal stem cell Kaposi's sarcoma progenitors by enabling KSHV oncogenesis in an angiogenic environment. PLoS Pathog 15(12):e1008221. https://doi.org/10.1371/journal.ppat.1008221 CrossRefPubMedPubMedCentral

144.

McHugh D, Caduff N, Barros MHM, Ramer PC, Raykova A, Murer A, Landtwing V, Quast I, Styles CT, Spohn M, Fowotade A, Delecluse HJ, Papoudou-Bai A, Lee YM, Kim JM, Middeldorp J, Schulz TF, Cesarman E, Zbinden A, Capaul R, White RE, Allday MJ, Niedobitek G, Blackbourn DJ, Grundhoff A, Munz C (2017) Persistent KSHV infection increases EBV-associated tumor formation in vivo via enhanced EBV lytic gene expression. Cell Host Microbe 22(1):61–73 e67. https://doi.org/10.1016/j.chom.2017.06.009 CrossRefPubMed

Title: Epigenetic control in Kaposi sarcoma-associated herpesvirus infection and associated disease
Authors: Jacqueline Fröhlich
Adam Grundhoff
Publication date: 01-04-2020
Publisher: Springer Berlin Heidelberg
Keywords: Herpes Virus
Kaposi Sarcoma
Kaposi Sarcoma
Epigenetics
Published in: Seminars in Immunopathology / Issue 2/2020
Print ISSN: 1863-2297
Electronic ISSN: 1863-2300
DOI: https://doi.org/10.1007/s00281-020-00787-z

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