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01-09-2019 | Septicemia | Introduction

Osteoimmunology: entwined regulation of integrated systems

Author: Mary C. Nakamura

Published in: Seminars in Immunopathology | Issue 5/2019

Excerpt

Osteoimmunology is the study of the close interrelationships between the skeletal and the immune systems that begin in development and continue as important functional regulators of both systems throughout life. Bone is a complex organ which both houses and influences immune cell development, differentiation, and function. The osteoclast, the important bone degrading cell, is a highly differentiated immune cell which is regulated by similar mechanisms as its myeloid cell relatives. Conversely, bone cells can influence immune cell development and immune responses, which can also have a significant impact during disease pathology. This issue focused on osteoimmunology that includes a set of new reviews that emphasize how regulation of immune function occurs in concert with the regulation of bone turnover, which has significant implications for the outcomes of bone density and disease due to immune activation during infection, autoimmunity, and aging. …

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Title: Osteoimmunology: entwined regulation of integrated systems
Author: Mary C. Nakamura
Publication date: 01-09-2019
Publisher: Springer Berlin Heidelberg
Keywords: Septicemia
Septicemia
Published in: Seminars in Immunopathology / Issue 5/2019
Print ISSN: 1863-2297
Electronic ISSN: 1863-2300
DOI: https://doi.org/10.1007/s00281-019-00763-2

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Other articles of this Issue 5/2019

Osteoclastic microRNAs and their translational potential in skeletal diseases

Metabolic reprogramming in osteoclasts

γδ T cells in rheumatic diseases: from fundamental mechanisms to autoimmunity

Molecular determinants for the polarization of macrophage and osteoclast

The role of bone cells in immune regulation during the course of infection

An emerging role for Toll-like receptors at the neuroimmune interface in osteoarthritis

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