Top

Published in:

01-05-2019 | Chronic Inflammatory Bowel Disease | Introduction

Pathogenicity of acquired immunity in human diseases

Author: Kiyoshi Hirahara

Published in: Seminars in Immunopathology | Issue 3/2019

Excerpt

CD4⁺ helper T cells help the function of other immune cells and are thereby critical immune cells for the host defense against infection with harmful microorganisms. Thus, this population plays a central role in adaptive immunity. However, CD4⁺ helper T cells can also be involved in the pathology of various immune-related inflammatory diseases, including allergic diseases and auto-immune diseases [1, 2] (Fig. 1). In the classical point of view, helper T cells were recognized to have two major fates, T helper 1 (Th1) and Th2 cells, but recent advances in research have revealed opportunities for diverse helper T cell subsets, beyond Th1 and Th2 cells. The new subsets of helper T cells include follicular helper T (Tfh) cells, Th9, Th17, Th22, and different types of regulatory T cells [3‐6]. …

Nakayama T, Hirahara K, Onodera A, Endo Y, Hosokawa H, Shinoda K, Tumes DJ, Okamoto Y (2017) Th2 cells in health and disease. Annu Rev Immunol 35:53–84CrossRefPubMed

Sallusto F (2016) Heterogeneity of human CD4(+) T cells against microbes. Annu Rev Immunol 34:317–334CrossRefPubMed

Korn T, Bettelli E, Oukka M, Kuchroo VK (2009) IL-17 and Th17 cells. Annu Rev Immunol 27:485–517CrossRef

Zhu J, Yamane H, Paul WE (2010) Differentiation of effector CD4 T cell populations. Annu Rev Immunol 28:445–489CrossRefPubMedPubMedCentral

Crotty S (2011) Follicular helper CD4 T cells (TFH). Annu Rev Immunol 29:621–663CrossRef

Panduro M, Benoist C, Mathis D (2016) Tissue Tregs. Annu Rev Immunol 34:609–633CrossRefPubMedPubMedCentral

Hirota K, Ahlfors H, Duarte JH, Stockinger B (2012) Regulation and function of innate and adaptive interleukin-17-producing cells. EMBO Rep 13(2):113–120CrossRefPubMed

Yasuda K, Takeuchi Y, Hirota K (2019) The pathogenicity of Th17 cells in autoimmune diseases. Semin Immunopathol. https://doi.org/10.1007/s00281-019-00733-8

Hirota K, Hashimoto M, Ito Y, Matsuura M, Ito H, Tanaka M, Watanabe H, Kondoh G, Tanaka A, Yasuda K, Kopf M, Potocnik AJ, Stockinger B, Sakaguchi N, Sakaguchi S (2018) Autoimmune Th17 cells induced synovial stromal and innate lymphoid cell secretion of the cytokine GM-CSF to initiate and augment autoimmune arthritis. Immunity 48(6):1220–1232 e5CrossRefPubMedPubMedCentral

10.

Wing JB, Tanaka A, Sakaguchi S (2019) Human FOXP3(+) regulatory T cell heterogeneity and function in autoimmunity and cancer. Immunity 50(2):302–316CrossRefPubMed

11.

Göschl L, Scheinecker C, Bonelli M (2019) Treg cells in autoimmunity: from identification to Treg-based therapies. Semin Immunopathol. https://doi.org/10.1007/s00281-019-00741-8

12.

O’Shea JJ, Paul WE (2010) Mechanisms underlying lineage commitment and plasticity of helper CD4+ T cells. Science 327(5969):1098–1102CrossRefPubMedPubMedCentral

13.

Schmidl C, Delacher M, Huehn J, Feuerer M (2018) Epigenetic mechanisms regulating T-cell responses. J Allergy Clin Immunol 142(3):728–743CrossRefPubMed

14.

Liu H, Li P, Wie Z, Zhang C, Xia M, Du Q, Chen Y, Liu N, Li H, Yang X-P (2019) Regulation of T cell differentiation and function by epigenetic modification enzymes. Semin Immunopathol. https://doi.org/10.1007/s00281-019-00731-w

15.

Kurachi M (2019) CD8⁺ T cell exhaustion. Semin Immunopathol. https://doi.org/10.1007/s00281-019-00744-5

16.

Giladi A, Amit I (2018) Single-cell genomics: a stepping stone for future immunology discoveries. Cell 172(1–2):14–21CrossRefPubMed

17.

Endo Y, Iwamura C, Kuwahara M, Suzuki A, Sugaya K, Tumes DJ, Tokoyoda K, Hosokawa H, Yamashita M, Nakayama T (2011) Eomesodermin controls interleukin-5 production in memory T helper 2 cells through inhibition of activity of the transcription factor GATA3. Immunity 35(5):733–745CrossRefPubMed

18.

Islam SA, Chang DS, Colvin RA, Byrne MH, McCully ML, Moser B, Lira SA, Charo IF, Luster AD (2011) Mouse CCL8, a CCR8 agonist, promotes atopic dermatitis by recruiting IL-5+ T(H)2 cells. Nat Immunol 12(2):167–177CrossRefPubMed

19.

Endo Y, Hirahara K, Iinuma T, Shinoda K, Tumes DJ, Asou HK, Matsugae N, Obata-Ninomiya K, Yamamoto H, Motohashi S, Oboki K, Nakae S, Saito H, Okamoto Y, Nakayama T (2015) The interleukin-33-p38 kinase axis confers memory T helper 2 cell pathogenicity in the airway. Immunity 42(2):294–308CrossRefPubMed

20.

Mitson-Salazar A, Yin Y, Wansley DL, Young M, Bolan H, Arceo S, Ho N, Koh C, Milner JD, Stone KD, Wank SA, Prussin C (2016) Hematopoietic prostaglandin D synthase defines a proeosinophilic pathogenic effector human TH2 cell subpopulation with enhanced function. J Allergy Clin Immunol 137(3):907–918 e9CrossRefPubMed

21.

Wambre E, Bajzik V, DeLong JH, O’Brien K, Nguyen QA, Speake C, Gersuk VH, DeBerg HA, Whalen E, Ni C, Farrington M, Jeong D, Robinson D, Linsley PS, Vickery BP, Kwok WW (2017) A phenotypically and functionally distinct human TH2 cell subpopulation is associated with allergic disorders. Sci Transl Med 9(401):eaam9171CrossRefPubMedPubMedCentral

22.

Mato N, Hirahara K, Ichikawa T, Kumagai J, Nakayama M, Yamasawa H, Bando M, Hagiwara K, Sugiyama Y, Nakayama T (2017) Memory-type ST2+CD4+ T cells participate in the steroid-resistant pathology of eosinophilic pneumonia. Sci Rep 7(1):6805CrossRefPubMedPubMedCentral

23.

Morimoto Y, Hirahara K, Kiuchi M, Wada T, Ichikawa T, Kanno T, Okano M, Kokubo K, Onodera A, Sakurai D, Okamoto Y, Nakayama T (2018) Amphiregulin-producing pathogenic memory T helper-2 cells instruct eosinophils to secrete osteopontin and facilitate airway fibrosis. Immunity In press 49:134–150.e6CrossRefPubMed

24.

Gieseck RL 3rd, Wilson MS, Wynn TA (2018) Type 2 immunity in tissue repair and fibrosis. Nat Rev Immunol 18(1):62–76CrossRefPubMed

25.

Lambrecht BN, Hammad H (2015) The immunology of asthma. Nat Immunol 16(1):45–56CrossRef

26.

Hirahara K, Aoki A, Morimoto Y, Kiuchi M, Okano M, Nakayama T (2019) The immunopathology of lung fibrosis: amphiregulin-producing pathogenic memory T helper-2 cells control the airway fibrotic responses by inducing eosinophils to secrete osteopontin. Semin Immunopathol. https://doi.org/10.1007/s00281-019-00735-6

27.

Kimura MY, Koyama-Nasu R, Yagi R, Nakayama T (2019) A new therapeutic target: the CD69-Myl9 system in immune responses. Semin Immunopathol. https://doi.org/10.1007/s00281-019-00734-7

28.

Yazdi AS, Rocken M, Ghoreschi K (2016) Cutaneous immunology: basics and new concepts. Semin Immunopathol 38(1):3–10CrossRefPubMed

29.

Sabat R, Wolk K, Loyal L, Döcke WD, Ghoreschi K (2019) T cell pathology in skin inflammation. Semin Immunopathol. https://doi.org/10.1007/s00281-019-00742-7

30.

Kanai T, Mikami Y, Hayashi A (2015) A breakthrough in probiotics: Clostridium butyricum regulates gut homeostasis and anti-inflammatory response in inflammatory bowel disease. J Gastroenterol 50(9):928–939CrossRef

31.

Hagihara Y, Yoshimatsu Y, Mikami Y, Takada Y, Mizuno S, Kanai T (2019) Epigenetic regulation of T helper cells and intestinal pathogenicity. Semin Immunopathol. https://doi.org/10.1007/s00281-019-00732-9

32.

Yip KH, Papadopoulos M, Pant H, Tumes DJ (2019) The role of invariant T cells in inflammation of the skin and airways. Semin Immunopathol. https://doi.org/10.1007/s00281-019-00740-9

Title: Pathogenicity of acquired immunity in human diseases
Author: Kiyoshi Hirahara
Publication date: 01-05-2019
Publisher: Springer Berlin Heidelberg
Keywords: Chronic Inflammatory Bowel Disease
Epigenetics
Published in: Seminars in Immunopathology / Issue 3/2019
Print ISSN: 1863-2297
Electronic ISSN: 1863-2300
DOI: https://doi.org/10.1007/s00281-019-00739-2

ACC 2024 Congress Coverage

Heart Failure Video

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Pathogenicity of acquired immunity in human diseases

Excerpt

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

» View more highlights on the ACC 2024 congress hub page

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Excerpt

Please log in to get access to this content

Other articles of this Issue 3/2019

The role of invariant T cells in inflammation of the skin and airways

Epigenetic regulation of T helper cells and intestinal pathogenicity

Correction to: The pathogenicity of Th17 cells in autoimmune diseases

Regulation of T cell differentiation and function by epigenetic modification enzymes

CD8+ T cell exhaustion

The pathogenicity of Th17 cells in autoimmune diseases

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

» View more highlights on the ACC 2024 congress hub page