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Seminars in Immunopathology
Published in: Seminars in Immunopathology 4/2017

01-06-2017 | Review

Synovial cellular and molecular markers in rheumatoid arthritis

Authors: M. Asif Amin, David A. Fox, Jeffrey H. Ruth

Published in: Seminars in Immunopathology | Issue 4/2017

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Abstract

The profound alterations in the structure, cellular composition, and function of synovial tissue in rheumatoid arthritis (RA) are the basis for the persistent inflammation and cumulative joint destruction that are hallmarks of this disease. In RA, the synovium develops characteristics of a tertiary lymphoid organ, with extensive infiltration of lymphocytes and myeloid cells. Concurrently, the fibroblast-like synoviocytes undergo massive hyperplasia and acquire a tissue-invasive phenotype. In this review, we summarize key components of these processes, focusing on recently-described roles of selected molecular markers of these cellular components of RA synovitis.
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Metadata
Title
Synovial cellular and molecular markers in rheumatoid arthritis
Authors
M. Asif Amin
David A. Fox
Jeffrey H. Ruth
Publication date
01-06-2017
Publisher
Springer Berlin Heidelberg
Published in
Seminars in Immunopathology / Issue 4/2017
Print ISSN: 1863-2297
Electronic ISSN: 1863-2300
DOI
https://doi.org/10.1007/s00281-017-0631-3

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