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Seminars in Immunopathology
Published in: Seminars in Immunopathology 4/2017

01-06-2017 | Review

Arthritis models: usefulness and interpretation

Authors: Natacha Bessis, Patrice Decker, Eric Assier, Luca Semerano, Marie-Christophe Boissier

Published in: Seminars in Immunopathology | Issue 4/2017

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Abstract

Animal models of arthritis are used to better understand pathophysiology of a disease or to seek potential therapeutic targets or strategies. Focusing on models currently used for studying rheumatoid arthritis, we show here in which extent models were invaluable to enlighten different mechanisms such as the role of innate immunity, T and B cells, vessels, or microbiota. Moreover, models were the starting point of in vivo application of cytokine-blocking strategies such as anti-TNF or anti-IL-6 treatments. The most popular models are the different types of collagen-induced arthritis and arthritis in KBN mice. As spontaneous arthritides, human TNF-α transgenic mice are a reliable model. It is mandatory to use animal models in the respect of ethical procedure, particularly regarding the number of animals and the control of pain. Moreover, design of experiments should be of the highest level, animal models of arthritis being dedicated to exploration of well-based novelties, and never used for confirmation or replication of already proven concepts. The best interpretations of data in animal models of arthritis suppose integrated research, including translational studies from animals to humans.
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Metadata
Title
Arthritis models: usefulness and interpretation
Authors
Natacha Bessis
Patrice Decker
Eric Assier
Luca Semerano
Marie-Christophe Boissier
Publication date
01-06-2017
Publisher
Springer Berlin Heidelberg
Published in
Seminars in Immunopathology / Issue 4/2017
Print ISSN: 1863-2297
Electronic ISSN: 1863-2300
DOI
https://doi.org/10.1007/s00281-017-0622-4

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