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Seminars in Immunopathology
Published in: Seminars in Immunopathology 2/2010

01-06-2010 | Review

Regulatory T cells: roles of T cell receptor for their development and function

Authors: Naganari Ohkura, Shimon Sakaguchi

Published in: Seminars in Immunopathology | Issue 2/2010

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Abstract

Naturally arising CD4+CD25+ regulatory T cells (Treg cells), which specifically express the forkhead family transcription factor Foxp3, are essential for the maintenance of immunological self-tolerance and immune homeostasis. Stimulation of the T cell antigen receptor (TCR) via recognizing self-peptide/major histocompatibility complex (MHC) is required for their expression of Foxp3 in the course of their development in the thymus. The TCR repertoires displayed by Treg cells and naïve T cells are apparently distinct, suggesting that Treg cells with high reactivity to self-peptide/MHC ligands are somehow driven to Treg cell lineage in the thymus. Treg cells also require stimulation via TCR to exert suppression in the periphery. At the molecular level, assembly of Foxp3, Foxp3-interacting factors, and chromatin-remodeling factors is in part under the control of TCR signaling, and TCR stimulation alters Foxp3-dependent transcriptional regulation, protein–protein interaction, and Foxp3 recruitment to the specific genomic loci. These findings collectively indicate that the TCR signaling is essential for suppressive function of Treg cells and that TCR has a determinant role for driving developing T cells to the Foxp3+CD4+CD25+ Treg cell lineage and differentiation.
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Metadata
Title
Regulatory T cells: roles of T cell receptor for their development and function
Authors
Naganari Ohkura
Shimon Sakaguchi
Publication date
01-06-2010
Publisher
Springer-Verlag
Published in
Seminars in Immunopathology / Issue 2/2010
Print ISSN: 1863-2297
Electronic ISSN: 1863-2300
DOI
https://doi.org/10.1007/s00281-010-0200-5

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